ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0043066
Name	negative regulation of apoptotic process
Type	Biological Process
No. of Genes in ADHDgene	77
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 77)

Literature-origin genes (count: 7)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
TRIM32	tripartite motif containing 32	9q33.1	1(0/0/1)	IDA[18632609]
VEGFA	vascular endothelial growth factor A	6p12	1(0/1/0)	IMP[10066377]
FGF10	fibroblast growth factor 10	5p13-p12	1(0/1/0)
GSK3B	glycogen synthase kinase 3 beta	3q13.3	1(1/0/0)	IDA[14744935]
IL1RN	interleukin 1 receptor antagonist	2q14.2	2(1/1/0)
GDNF	glial cell derived neurotrophic factor	5p13.1-p12	2(1/1/0)	TAS[7830769]
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	4q21.3-q22	1(0/1/0)	IMP[10818098]

Genes from other sources (count: 70)

Approved Symbol	Approved Name	Source	Evidence[PMID]
TGFBR1	transforming growth factor, beta receptor 1	Mapped by significant region	IMP[18625725]
ATM	ataxia telangiectasia mutated	Mapped by CNV; Mapped by significant region
TAX1BP1	Tax1 (human T-cell leukemia virus type I) binding protein 1	Mapped by significant region
ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	Mapped by PBA pathway
YAP1	Yes-associated protein 1	Mapped by significant region
CFL1	cofilin 1 (non-muscle)	Mapped by significant region	TAS[16130169]
BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	Mapped by CNV	TAS[7954800]
BARD1	BRCA1 associated RING domain 1	Mapped by significant region	IMP[15265711]
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	Mapped by CNV
TNFSF18	tumor necrosis factor (ligand) superfamily, member 18	Mapped by significant region	TAS[10074428]
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	Mapped by significant region	NAS[11090634]
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	Mapped by significant region
IL6	interleukin 6 (interferon, beta 2)	Mapped by significant region	IDA[7595060]; IMP[18719127]
VNN1	vanin 1	Mapped by significant region	ISS[15282320]
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	Mapped by significant region	IMP[18070883]
DPEP1	dipeptidase 1 (renal)	Mapped by significant region
GATA6	GATA binding protein 6	Mapped by significant region
AHI1	Abelson helper integration site 1	Mapped by significant region
PRDX5	peroxiredoxin 5	Mapped by significant region	IMP[18262354]
SYNGAP1	synaptic Ras GTPase activating protein 1	Mapped by LD-proxy; Mapped by literature SNP
F7	coagulation factor VII (serum prothrombin conversion accelerator)	Mapped by CNV	TAS[18612547]
API5	apoptosis inhibitor 5	Mapped by PBA pathway	IMP[11075807]; ISS[9307294]; NAS[10780674]
BTC	betacellulin	Mapped by CNV
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	Mapped by significant region	IDA[12167698]
BIRC2	baculoviral IAP repeat containing 2	Mapped by significant region
KLHL20	kelch-like 20 (Drosophila)	Mapped by significant region
INS	insulin	Mapped by literature SNP	NAS[16604263]
PLK1	polo-like kinase 1	Mapped by significant region	IMP[18174154]
HNF1B	HNF1 homeobox B	Mapped by CNV
PALB2	partner and localizer of BRCA2	Mapped by significant region
RRN3	RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)	Mapped by CNV; Mapped by significant region
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	Mapped by significant region	IDA[15734730]
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	Mapped by significant region
PAK7	p21 protein (Cdc42/Rac)-activated kinase 7	Mapped by CNV
EDNRA	endothelin receptor type A	Mapped by PBA pathway
AATF	apoptosis antagonizing transcription factor	Mapped by CNV	IMP[15207272]
MIEN1	migration and invasion enhancer 1	Mapped by LD-proxy
MED1	mediator complex subunit 1	Mapped by LD-proxy; Mapped by PBA pathway
PRLR	prolactin receptor	Mapped by significant region	NAS[10585417]
FGF4	fibroblast growth factor 4	Mapped by significant region
CXCL12	chemokine (C-X-C motif) ligand 12	Mapped by PBA pathway
ATG5	ATG5 autophagy related 5 homolog (S. cerevisiae)	Mapped by CNV
BIRC6	baculoviral IAP repeat containing 6	Mapped by CNV	IMP[15200957]; TAS[10544019]
SORT1	sortilin 1	Mapped by CNV	IDA[14985763]
APC	adenomatous polyposis coli	Mapped by LD-proxy; Mapped by PBA pathway
WNT11	wingless-type MMTV integration site family, member 11	Mapped by significant region
NUP62	nucleoporin 62kDa	Mapped by PBA pathway	IDA[11755531]
VEGFB	vascular endothelial growth factor B	Mapped by significant region	IDA[18259607]
BDKRB2	bradykinin receptor B2	Mapped by PBA pathway
CLCF1	cardiotrophin-like cytokine factor 1	Mapped by significant region	TAS[14632778]
G2E3	G2/M-phase specific E3 ubiquitin protein ligase	Mapped by significant region
AVEN	apoptosis, caspase activation inhibitor	Mapped by CNV	IDA[10949025]
SYVN1	synovial apoptosis inhibitor 1, synoviolin	Mapped by significant region
FLT4	fms-related tyrosine kinase 4	Mapped by CNV	IMP[11532940]
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	Mapped by significant region
PDCD10	programmed cell death 10	Mapped by CNV	IDA[17360971]
SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	Mapped by significant region	TAS[8876214]
HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	Mapped by significant region	IMP[12665508]; TAS[16130169]
GSTP1	glutathione S-transferase pi 1	Mapped by significant region	IDA[16636664]; TAS[16130169]
KDM1A	lysine (K)-specific demethylase 1A	Mapped by LD-proxy	IMP[17805299]
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mapped by significant region	IDA[10747850]
PRKAA1	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mapped by significant region
MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mapped by CNV	IDA[17045821]
CRYAB	crystallin, alpha B	Mapped by significant region	IDA[14752512]
BIRC3	baculoviral IAP repeat containing 3	Mapped by significant region	TAS[8552191]
KRT18	keratin 18	Mapped by PBA pathway	IDA[11684708]
FAM129B	family with sequence similarity 129, member B	Mapped by significant region
PIK3CG	phosphoinositide-3-kinase, catalytic, gamma polypeptide	Mapped by CNV
CFDP1	craniofacial development protein 1	Mapped by significant region
MAPK7	mitogen-activated protein kinase 7	Mapped by significant region