ADHDgene Database

Gene Report

Basic Info

Approved Symbol	KRT18
Approved Name	keratin 18
Location	12q13
Position	chr12:53342655-53346685, +
External Links	HGNC: 6430 Entrez Gene: 3875 Ensembl: ENSG00000111057 UCSC: uc001sbg.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0048193	Golgi vesicle transport	Biological Process		49

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0097110	scaffold protein binding	Molecular Function	IPI[10852826]	6
GO:0043000	Golgi to plasma membrane CFTR protein transport	Biological Process	IDA[15529338]	1
GO:0034451	centriolar satellite	Cellular Component	IDA[18000879]	4
GO:0033209	tumor necrosis factor-mediated signaling pathway	Biological Process		6
GO:0019048	virus-host interaction	Biological Process		54
GO:0048471	perinuclear region of cytoplasm	Cellular Component		87
GO:0045095	keratin filament	Cellular Component	IDA[16424149]	6
GO:0043066	negative regulation of apoptotic process	Biological Process	IDA[11684708]	77
GO:0005515	protein binding	Molecular Function		910
GO:0005730	nucleolus	Cellular Component		243
GO:0005737	cytoplasm	Cellular Component		690
GO:0005815	microtubule organizing center	Cellular Component	IDA[18000879]	19
GO:0005882	intermediate filament	Cellular Component	IDA[10852826]	3
GO:0006915	apoptotic process	Biological Process		111
GO:0007049	cell cycle	Biological Process		31
GO:0009653	anatomical structure morphogenesis	Biological Process	TAS[2434380]	26
GO:0005198	structural molecule activity	Molecular Function		29

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05130	Pathogenic Escherichia coli infection	17	Eenteropathogenic E. coli (EPEC) and enterohemorrhagic E. co...... Eenteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction of attaching and effacing (A/E) lesions that damage intestinal epithelial cells. The capacity to form A/E lesions is encoded mainly by the locus of enterocyte effacement (LEE) pathogenicity island. Tir, Map, EspF, EspG are known LEE-encoded effector proteins secreted via the type III secretion system, which is also LEE-encoded, into the host cell. EPEC and EHEC Tir's link the extracellular bacterium to the cell cytoskeleton. Map and EspF are involved in mitochondrion membrane permeabilization. EspG interacts with tubulins and stimulates microtubule destabilization. LEE-encoded adhesin or intimin (Eae) is exported via the general secretory pathway to the periplasm, where it is inserted into the outer membrane. In addition to Tir, two potential host cell-carried intimin receptors, beta1 integrin (ITGB1) and nucleolin (NCL), have so far been identified. The distinguishing feature of EHEC is the elaboration of Shiga-like toxin (Stx). Stx cleaves ribosomal RNA, thereby disrupting protein synthesis and killing the intoxicated epithelial or endothelial cells. More...

Genes shared at least 5 GO terms with KRT18 (count: 9)

Gene Symbol	Pathway Count	Pathway List
MAPK1	7	virus-host interaction; protein binding; nucleolus; cytoplasm; microtubule organizing center; apoptotic process; cell cycle;
BNIP3	5	virus-host interaction; negative regulation of apoptotic process; protein binding; cytoplasm; apoptotic process;
DAXX	5	virus-host interaction; protein binding; nucleolus; cytoplasm; apoptotic process;
MAPK3	5	virus-host interaction; protein binding; nucleolus; apoptotic process; cell cycle;
PSMC3	5	virus-host interaction; perinuclear region of cytoplasm; protein binding; cytoplasm; apoptotic process;
GSK3B	5	perinuclear region of cytoplasm; negative regulation of apoptotic process; protein binding; nucleolus; cytoplasm;
KLHL20	5	perinuclear region of cytoplasm; negative regulation of apoptotic process; protein binding; nucleolus; cytoplasm;
MALT1	5	perinuclear region of cytoplasm; negative regulation of apoptotic process; protein binding; nucleolus; cytoplasm;
AATF	5	negative regulation of apoptotic process; protein binding; nucleolus; cytoplasm; apoptotic process;

Genes shared at least 2 KEGG pathways with KRT18 (count: 0)

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Region: chr12:53342655..53346685 View in gBrowse