ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	F7
Approved Name	coagulation factor VII (serum prothrombin conversion accelerator)
Name Alias	eptacog alfa, "FVII coagulation protein", "factor VII"
Location	13q34
Position	chr13:113760105-113774995, +
External Links	HGNC: 3544 Entrez Gene: 2155 Ensembl: ENSG00000057593 UCSC: uc001vsw.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2010]_155	chr13:112336427-112835822 (NCBI Build 35 (hg17))	499396	13q34	Duplication	Maternal

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 29)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 29)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0030335	positive regulation of cell migration	Biological Process	TAS[18612547]	29
GO:0031100	organ regeneration	Biological Process		11
GO:0031982	vesicle	Cellular Component		6
GO:0032571	response to vitamin K	Biological Process		1
GO:0008236	serine-type peptidase activity	Molecular Function	TAS[3037537]	11
GO:0010641	positive regulation of platelet-derived growth factor receptor signaling pathway	Biological Process	IDA[17991872]	1
GO:0017187	peptidyl-glutamic acid carboxylation	Biological Process		4
GO:0030194	positive regulation of blood coagulation	Biological Process		1
GO:0050927	positive regulation of positive chemotaxis	Biological Process	IDA[17991872]	3
GO:0051897	positive regulation of protein kinase B signaling cascade	Biological Process	IDA[18612547]	17
GO:0060416	response to growth hormone stimulus	Biological Process		2
GO:0043066	negative regulation of apoptotic process	Biological Process	TAS[18612547]	77
GO:0043627	response to estrogen stimulus	Biological Process		11
GO:0043687	post-translational protein modification	Biological Process		37
GO:0044267	cellular protein metabolic process	Biological Process		64
GO:0005102	receptor binding	Molecular Function		61
GO:0004252	serine-type endopeptidase activity	Molecular Function		29
GO:0005576	extracellular region	Cellular Component		240
GO:0005509	calcium ion binding	Molecular Function		124
GO:0002690	positive regulation of leukocyte chemotaxis	Biological Process	IDA[17991872]	3
GO:0001948	glycoprotein binding	Molecular Function	IPI[3455766]	3
GO:0007596	blood coagulation	Biological Process		83
GO:0006508	proteolysis	Biological Process		102
GO:0007623	circadian rhythm	Biological Process		15
GO:0007598	blood coagulation, extrinsic pathway	Biological Process		2
GO:0005788	endoplasmic reticulum lumen	Cellular Component		33
GO:0005615	extracellular space	Cellular Component		126
GO:0005886	plasma membrane	Cellular Component		772
GO:0005796	Golgi lumen	Cellular Component		12

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04610	Complement and coagulation cascades	12	The complement system is a proteolytic cascade in blood plas...... The complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation: the classical pathway, the lectin pathway, and the alternative pathway. All of these pathways generate a crucial enzymatic activity that, in turn, generates the effector molecules of complement. The main consequences of complement activation are the opsonization of pathogens, the recruitment of inflammatory and immunocompetent cells, and the direct killing of pathogens. Blood coagulation is another series of proenzyme-to-serine protease conversions, culminating the formation of thrombin, the enzyme responsible for the conversion of soluble fibrinogen to the insoluble fibrin clot. Protease-activated receptors, such as those activated by thrombin, are members of G protein-coupled receptors and function as a mediator of innate immunity. The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium homeostasis, inflammatory processes, and the cardioprotective effects of preconditioning. More...

Genes shared at least 5 GO terms with F7 (count: 15)

Gene Symbol	Pathway Count	Pathway List
F10	14	positive regulation of cell migration; peptidyl-glutamic acid carboxylation; positive regulation of protein kinase B signaling cascade; post-translational protein modification; cellular protein metabolic process; serine-type endopeptidase activity; extracellular region; calcium ion binding; blood coagulation; proteolysis; blood coagulation, extrinsic pathway; endoplasmic reticulum lumen; plasma membrane; Golgi lumen;
FURIN	8	peptidyl-glutamic acid carboxylation; post-translational protein modification; cellular protein metabolic process; serine-type endopeptidase activity; proteolysis; extracellular space; plasma membrane; Golgi lumen;
INS	7	positive regulation of cell migration; positive regulation of protein kinase B signaling cascade; negative regulation of apoptotic process; extracellular region; endoplasmic reticulum lumen; extracellular space; Golgi lumen;
APOA1	7	organ regeneration; response to estrogen stimulus; extracellular region; blood coagulation; endoplasmic reticulum lumen; extracellular space; plasma membrane;
VEGFA	6	positive regulation of cell migration; positive regulation of positive chemotaxis; negative regulation of apoptotic process; extracellular region; blood coagulation; extracellular space;
PRSS8	6	serine-type peptidase activity; serine-type endopeptidase activity; extracellular region; proteolysis; extracellular space; plasma membrane;
CDH13	5	positive regulation of cell migration; positive regulation of positive chemotaxis; calcium ion binding; extracellular space; plasma membrane;
SEMA4D	5	positive regulation of cell migration; negative regulation of apoptotic process; receptor binding; extracellular space; plasma membrane;
ST14	5	serine-type peptidase activity; serine-type endopeptidase activity; extracellular region; proteolysis; plasma membrane;
IL6	5	positive regulation of protein kinase B signaling cascade; negative regulation of apoptotic process; extracellular region; positive regulation of leukocyte chemotaxis; extracellular space;
VEGFB	5	positive regulation of protein kinase B signaling cascade; negative regulation of apoptotic process; extracellular region; blood coagulation; extracellular space;
EDEM2	5	post-translational protein modification; cellular protein metabolic process; extracellular region; calcium ion binding; endoplasmic reticulum lumen;
MMP13	5	cellular protein metabolic process; extracellular region; calcium ion binding; proteolysis; extracellular space;
CTSG	5	serine-type endopeptidase activity; extracellular region; proteolysis; extracellular space; plasma membrane;
MMP8	5	serine-type endopeptidase activity; extracellular region; calcium ion binding; proteolysis; extracellular space;

Genes shared at least 2 KEGG pathways with F7 (count: 0)

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Region: chr13:113760105..113774995 View in gBrowse