ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Study Report

Basic Info

Reference	Li J, 2006(a)16959425
Citation	Li J., Wang Y., Zhou R., Zhang H., Yang L., Wang B. and Faraone S. V. (2006) "Association between polymorphisms in serotonin 2C receptor gene and attention-deficit/hyperactivity disorder in Han Chinese subjects." Neurosci Lett, 407(2): 107-11.
Study Design	family-based
Study Type	Candidate-gene association study
Sample Size	488 Han Chinese families
Predominant Ethnicity	Mongoloid
Population	China
Gender	409 males probands, 79 females probands
Age Group	Children/Adolescents : 6 to 17.5 years, with a mean age of 10.3,SD=2.8 years

Detail Info

Summary	In the current study, they examined the relationship between the C-759T and G-697C polymorphisms of HTR2C and ADHD in 488 Han Chinese families. Transmission Disequilibrium Test (TDT) analysis showed that the -759C allele, the -697G allele, and haplotype -759C/-697G were significantly over-transmitted to affected probands, while haplotypes -759C/-697C and -759T/-697C were under-transmitted. When families were divided into three subtypes according to the diagnosis of probands, the -697G allele and haplotype -759C/-697G were significantly over transmitted to ADHD-C probands, while haplotype -759T/-697C was under-transmitted to these individuals; however, no biased transmission of any allele or haplotype was observed for probands with ADHD-I, suggesting that different subtypes of ADHD have different genetic influences.
Total Sample	Four hundred and nine unrelated male ADHD probands and their biological mothers, as well as 79 unrelated female ADHD probands and both biological parents, were recruited from the child psychiatric clinics at Peking University Institute of Mental Health from September 1999 to December 2003. The age of the probands ranged from 6 to 17.5 years, with a mean age of 10.3,SD=2.8 years.
Sample Collection	Han Chinese
Diagnosis Description	Affected children were diagnosed by experienced clinicians according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria for ADHD. Of the 488ADHDprobands, 205 (42.0%) probands met criteria for ADHD combined type (ADHD-C), 30 (6.2%) met criteria for ADHD hyperactive-impulsive type (ADHD-HI) and 253 (51.8%) met criteria for ADHD inattentive type (ADHD-I).
Technique	Venous blood samples were refrigerated at 4 ^oC in test tubes with EDTA. Genomic DNA was extracted using standard methods within 2 weeks. To genotype the C-759T (rs3813929) and G-697C (rs518147) polymorphisms, forward primers 5'-ATC TCC ACC ATG GGT CTC GC-3' (spanning nucleotide positions -885 through -866) and reverse primers 5'-CAA TCT AGC CGC TCC AAA GG-3' (spanning nucleotide positions -653 through-634) were used to generate a fragment of 252 bp. More details could be found in the original publication.
Analysis Method	The Transmission Disequilibrium Test (TDT) was performed to explore the possible linkage and association of alleles and haplotypes with ADHD.
Result Description	Transmission Disequilibrium Test (TDT) analysis showed that the -759C allele, the -697G allele, and haplotype -759C/-697G were significantly over-transmitted to affected probands, while haplotypes -759C/-697C and -759T/-697C were under-transmitted. When families were divided into three subtypes according to the diagnosis of probands, the -697G allele and haplotype -759C/-697G were significantly over transmitted to ADHD-C probands, while haplotype -759T/-697C was under-transmitted to these individuals; however, no biased transmission of any allele or haplotype was observed for probands with ADHD-I, suggesting that different subtypes of ADHD have different genetic influences.

SNPs reported by this study (count: 2)

SNP	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
rs518147	G/C		TDT P-value=0.01, X²=6.588 in ADHD; TDT P-value=0.041, X²=4.17 in ADHD-C; TDT P-value=0.261, X²=1.261 in ADHD-I	a preferential transmission of the G allele to ADHD probands...... a preferential transmission of the G allele to ADHD probands and biased transmission in families with ADHD-C probands More...	Significant
rs3813929	C/T		TDT P-value=0.045, X²=4.009 in ADHD; TDT P-value=0.175, X²=1.841 in ADHD-C; TDT P-value=0.298, X²=1.085 in ADHD-I	a preferential transmission of the C allele to ADHD probands a preferential transmission of the C allele to ADHD probands	Significant

Genes reported by this study (count: 1)