ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

SNP Report

Basic Info

Name	rs6592952 dbSNP Ensembl
Location	Chr7:50560255(Fwd)
Variant Alleles	C/A
Ancestral Allele	C
Functional Annotation	NMD_transcript_variant; downstream_gene_variant; intron_variant.
Consequence to Transcript	NMD_transcript_variant(ENST00000444733) downstream_gene_variant(ENST00000380984) intron_variant(ENST00000426377; ENST00000357936; ENST00000431062; ENST00000444733; ENST00000444124; ENST00000430300)
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Guan L, 2009			single SNP association analyses: Nominal P-value=0.003, Empi...... single SNP association analyses: Nominal P-value=0.003, Empirical P-value=0.032 for ADHD-I More...	non-significant for ADHD, but achieve nominal and empirical ...... non-significant for ADHD, but achieve nominal and empirical significance for ADHD-I More...	Significant

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
DDC	dopa decarboxylase (aromatic L-amino acid decarboxylase)	7p11	6(5/1/0)

Genes from other sources (count: 0)

SNPs in LD with rs6592952 (count: 33) View in gBrowse (chr7:50533539..50573848 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

Literature-origin SNPs (count: 2)

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs1349492	NMD_transcript_variant; intron_variant; nc_transcript_variant	1(1/0/0)	0.937[ASW]; 0.961[CEU]; 0.828[CHB]; 0.832[CHD]; 1.0[GIH]; 0.807[LWK]; 0.906[MKK]; 0.977[TSI]; 0.964[YRI]
rs1451371	NMD_transcript_variant; intron_variant	1(1/0/0)	0.823[CHB]

LD-proxies (count: 31)

rs_ID	Functional Annotation	r²[population]
rs10899735	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.935[ASW]; 0.961[CEU]; 0.828[CHB]; 0.832[CHD]; 1.0[GIH]; 0.807[LWK]; 0.906[MKK]; 0.977[TSI]; 0.964[YRI]
rs12718527	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.935[ASW]; 0.961[CEU]; 0.828[CHB]; 0.832[CHD]; 1.0[GIH]; 0.807[LWK]; 0.906[MKK]; 0.977[TSI]; 0.964[YRI]
rs12718541	NMD_transcript_variant; intron_variant; upstream_gene_variant	0.912[CEU]; 0.828[CHB]; 0.924[YRI]
rs4947577	NMD_transcript_variant; intron_variant; upstream_gene_variant	0.96[CEU]; 0.865[CHB]; 0.88[YRI]
rs11980368	NMD_transcript_variant; intron_variant; upstream_gene_variant	0.821[CEU]; 0.828[CHB]
rs11575457	NMD_transcript_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant	0.937[ASW]; 0.961[CEU]; 0.828[CHB]; 0.832[CHD]; 1.0[GIH]; 0.807[LWK]; 0.919[MKK]; 0.977[TSI]; 1.0[YRI]
rs7803247	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.821[CEU]; 0.864[GIH]; 0.93[TSI]
rs12718528	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.935[ASW]; 0.961[CEU]; 0.828[CHB]; 0.832[CHD]; 0.954[GIH]; 0.807[LWK]; 0.906[MKK]; 0.977[TSI]; 0.964[YRI]
rs4947582	NMD_transcript_variant; intron_variant	0.814[ASW]; 0.811[CHD]; 0.878[MKK]; 0.93[YRI]
rs13311361	NMD_transcript_variant; intron_variant; upstream_gene_variant	0.96[CEU]; 0.828[CHB]; 0.93[YRI]
rs4433100	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.961[CEU]; 0.828[CHB]; 0.93[YRI]
rs12718529	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.961[CEU]; 0.824[CHB]; 0.964[YRI]
rs4948196	NMD_transcript_variant; intron_variant; upstream_gene_variant	0.937[ASW]; 0.961[CEU]; 0.828[CHB]; 0.832[CHD]; 1.0[GIH]; 0.848[LWK]; 0.945[MKK]; 0.977[TSI]; 1.0[YRI]
rs12718574	NMD_transcript_variant; intron_variant	0.953[CHB]; 0.946[JPT]
rs2122822	NMD_transcript_variant; intron_variant; upstream_gene_variant	0.961[CEU]; 0.821[CHB]; 0.824[YRI]
rs2329365	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.961[CEU]; 0.821[CHB]; 0.874[YRI]
rs3887825	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.933[ASW]; 0.961[CEU]; 0.828[CHB]; 0.892[MKK]; 0.964[YRI]
rs3807566	NMD_transcript_variant; intron_variant	0.949[CHB]; 0.947[JPT]
rs4580999	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.935[ASW]; 0.961[CEU]; 0.828[CHB]; 0.832[CHD]; 1.0[GIH]; 0.807[LWK]; 0.906[MKK]; 0.977[TSI]; 0.964[YRI]
rs2876827	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.958[CEU]; 0.81[CHB]; 0.962[YRI]
rs7785224	NMD_transcript_variant; intron_variant	0.93[YRI]
rs11238138	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.96[CEU]; 0.828[CHB]; 0.964[YRI]
rs3823674	NMD_transcript_variant; intron_variant	0.953[CHB]; 0.894[CHD]; 0.948[JPT]
rs10899734	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.935[ASW]; 0.961[CEU]; 0.828[CHB]; 0.832[CHD]; 1.0[GIH]; 0.807[LWK]; 0.906[MKK]; 0.977[TSI]; 0.964[YRI]
rs1451372	NMD_transcript_variant; intron_variant	0.961[CEU]; 0.828[CHB]; 0.964[YRI]
rs730092	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.821[CEU]
rs11768267	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.821[CEU]; 0.864[GIH]; 0.907[TSI]
rs10899736	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.854[CHD]
rs4329234	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.961[CEU]; 1.0[CHB]; 1.0[JPT]; 0.857[YRI]
rs4579483	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.958[CEU]; 0.963[YRI]
rs4992502	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.937[ASW]; 0.961[CEU]; 0.828[CHB]; 0.832[CHD]; 1.0[GIH]; 0.807[LWK]; 0.893[MKK]; 0.977[TSI]; 0.964[YRI]