ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

SNP Report

Basic Info

Name	rs1349492 dbSNP Ensembl
Location	Chr7:50546459(Fwd)
Variant Alleles	G/A
Ancestral Allele	A
Functional Annotation	NMD_transcript_variant; intron_variant; nc_transcript_variant.
Consequence to Transcript	NMD_transcript_variant(ENST00000444733) intron_variant(ENST00000444733; ENST00000426377; ENST00000431062; ENST00000357936; ENST00000444124; ENST00000430300; ENST00000494914) nc_transcript_variant(ENST00000494914)
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Guan L, 2009			single SNP association analyses: Nominal P-value=0.025, Empi...... single SNP association analyses: Nominal P-value=0.025, Empirical P-value=0.206 for ADHD; Nominal P-value=0.006, Empirical P-value=0.052 for ADHD-I More...	achieve nominal significance for ADHD and ADHD-I achieve nominal significance for ADHD and ADHD-I	Significant

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
DDC	dopa decarboxylase (aromatic L-amino acid decarboxylase)	7p11	6(5/1/0)

Genes from other sources (count: 0)

SNPs in LD with rs1349492 (count: 32) View in gBrowse (chr7:50531681..50566090 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

Literature-origin SNPs (count: 3)

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs1451371	NMD_transcript_variant; intron_variant	1(1/0/0)	1.0[CHB]; 0.952[JPT]
rs732215	NMD_transcript_variant; intron_variant; nc_transcript_variant	1(1/0/0)	0.812[CHB]
rs6592952	NMD_transcript_variant; downstream_gene_variant; intron_variant	1(1/0/0)	0.937[ASW]; 0.961[CEU]; 0.828[CHB]; 0.832[CHD]; 1.0[GIH]; 0.807[LWK]; 0.906[MKK]; 0.977[TSI]; 0.964[YRI]

LD-proxies (count: 29)

rs_ID	Functional Annotation	r²[population]
rs10899736	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.954[CHB]; 0.976[CHD]; 0.953[JPT]
rs10899734	NMD_transcript_variant; intron_variant; nc_transcript_variant	1.0[ASW]; 1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[JPT]; 1.0[LWK]; 1.0[MEX]; 1.0[MKK]; 1.0[TSI]; 1.0[YRI]
rs3887825	NMD_transcript_variant; intron_variant; nc_transcript_variant	1.0[ASW]; 1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 0.986[MKK]; 1.0[YRI]
rs4947582	NMD_transcript_variant; intron_variant	0.882[ASW]; 0.954[CHB]; 0.928[CHD]; 0.953[JPT]; 0.813[LWK]; 0.943[MKK]; 0.894[YRI]
rs7785224	NMD_transcript_variant; intron_variant	0.949[JPT]; 0.894[YRI]
rs13311361	NMD_transcript_variant; intron_variant; upstream_gene_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 0.964[YRI]
rs4947535	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.811[JPT]
rs730092	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.854[CEU]; 0.864[CHB]; 0.858[JPT]
rs12718529	NMD_transcript_variant; intron_variant; nc_transcript_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 1.0[YRI]
rs10899735	NMD_transcript_variant; intron_variant; nc_transcript_variant	1.0[ASW]; 1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[JPT]; 1.0[LWK]; 1.0[MEX]; 1.0[MKK]; 1.0[TSI]; 1.0[YRI]
rs11768267	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.854[CEU]; 0.864[CHB]; 0.868[GIH]; 0.858[JPT]; 0.814[MEX]; 0.931[TSI]
rs4947577	NMD_transcript_variant; intron_variant; upstream_gene_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 0.919[YRI]
rs12718527	NMD_transcript_variant; intron_variant; nc_transcript_variant	1.0[ASW]; 1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[JPT]; 1.0[LWK]; 1.0[MEX]; 1.0[MKK]; 1.0[TSI]; 1.0[YRI]
rs7803247	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.854[CEU]; 0.822[CHB]; 0.868[GIH]; 0.814[MEX]; 0.954[TSI]
rs12718528	NMD_transcript_variant; intron_variant; nc_transcript_variant	1.0[ASW]; 1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 0.955[GIH]; 1.0[JPT]; 1.0[LWK]; 1.0[MEX]; 1.0[MKK]; 1.0[TSI]; 1.0[YRI]
rs11575457	NMD_transcript_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant	1.0[ASW]; 1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[JPT]; 1.0[LWK]; 0.948[MEX]; 0.986[MKK]; 1.0[TSI]; 0.964[YRI]
rs11238138	NMD_transcript_variant; intron_variant; nc_transcript_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 1.0[YRI]
rs4433100	NMD_transcript_variant; intron_variant; nc_transcript_variant	1.0[CEU]; 1.0[CHB]; 0.953[JPT]; 0.964[YRI]
rs2122822	NMD_transcript_variant; intron_variant; upstream_gene_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 0.857[YRI]
rs1451372	NMD_transcript_variant; intron_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 1.0[YRI]
rs4579483	NMD_transcript_variant; intron_variant; nc_transcript_variant	1.0[CEU]; 0.953[CHB]; 1.0[JPT]; 1.0[YRI]
rs4992502	NMD_transcript_variant; intron_variant; nc_transcript_variant	1.0[ASW]; 1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[JPT]; 1.0[LWK]; 1.0[MEX]; 0.986[MKK]; 1.0[TSI]; 1.0[YRI]
rs11980368	NMD_transcript_variant; intron_variant; upstream_gene_variant	0.854[CEU]; 1.0[CHB]; 1.0[JPT]
rs2876827	NMD_transcript_variant; intron_variant; nc_transcript_variant	1.0[CEU]; 1.0[CHB]; 0.945[JPT]; 1.0[YRI]
rs4948196	NMD_transcript_variant; intron_variant; upstream_gene_variant	1.0[ASW]; 1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[JPT]; 0.957[LWK]; 0.948[MEX]; 0.958[MKK]; 1.0[TSI]; 0.964[YRI]
rs2329365	NMD_transcript_variant; intron_variant; nc_transcript_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 0.918[YRI]
rs4329234	NMD_transcript_variant; intron_variant; nc_transcript_variant	1.0[CEU]; 0.823[CHB]; 0.824[YRI]
rs4580999	NMD_transcript_variant; intron_variant; nc_transcript_variant	1.0[ASW]; 1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[JPT]; 1.0[LWK]; 1.0[MEX]; 1.0[MKK]; 1.0[TSI]; 1.0[YRI]
rs12718541	NMD_transcript_variant; intron_variant; upstream_gene_variant	0.956[CEU]; 1.0[CHB]; 0.948[JPT]; 0.961[YRI]