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KEGG Pathway Report
Basic Info
| ID | hsa04630 |
|---|---|
| Name | Jak-STAT signaling pathway |
| Description | The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors. |
| No. of Genes in ADHDgene | 22 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 22)
Literature-origin genes (count: 3)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| CNTFR | ciliary neurotrophic factor receptor | 9p13 | 1(1/0/0) |
| CNTF | ciliary neurotrophic factor | 11q12 | 1(1/0/0) |
| IL20RA | interleukin 20 receptor, alpha | 6q23.3 | 1(0/0/1) |
Genes from other sources (count: 19)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| LIFR | leukemia inhibitory factor receptor alpha | 5p13-p12 | Mapped by significant region |
| IL7R | interleukin 7 receptor | 5p13 | Mapped by significant region |
| CLCF1 | cardiotrophin-like cytokine factor 1 | 11q13.3 | Mapped by significant region |
| PRLR | prolactin receptor | 5p14-p13 | Mapped by significant region |
| IL12B | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | 5q31.1-q33.1 | Mapped by significant region |
| IL10RA | interleukin 10 receptor, alpha | 11q23 | Mapped by significant region |
| CBL | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 11q23.3-qter | Mapped by significant region |
| IL6 | interleukin 6 (interferon, beta 2) | 7p21-p15 | Mapped by significant region |
| IL22RA2 | interleukin 22 receptor, alpha 2 | 6q24.1-q24.2 | Mapped by significant region |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 5q13.1 | Mapped by significant region |
| CCND1 | cyclin D1 | 11q13 | Mapped by significant region |
| OSMR | oncostatin M receptor | 5p13.2 | Mapped by significant region |
| PIK3CG | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 7q22 | Mapped by CNV |
| CTF1 | cardiotrophin 1 | 16p11.2 | Mapped by CNV |
| IL5RA | interleukin 5 receptor, alpha | 3p26-p24 | Mapped by CNV |
| GHR | growth hormone receptor | 5p14-p12 | Mapped by CNV; Mapped by significant region |
| IL11RA | interleukin 11 receptor, alpha | 9p13 | Mapped by LD-proxy |
| IFNGR1 | interferon gamma receptor 1 | 6q23-q24 | Mapped by significant region |
| IRF9 | interferon regulatory factor 9 | 14q11.2 | Mapped by significant region |