ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CTF1
Symbol Alias	CT-1
Approved Name	cardiotrophin 1
Location	16p11.2
Position	chr16:30904374-30914881, +
External Links	HGNC: 2499 Entrez Gene: 1489 Ensembl: ENSG00000150281 UCSC: uc002dzw.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 2)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_34	chr16:29342178-31155425 (NCBI Build 36.1 (hg18))	1813248	16p11.2	Loss	De novo
CNV_Williams[2010]_39	chr16:29342178-31155425 (NCBI Build 36.1 (hg18))	1813247	16p11.2	Gain

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0048666	neuron development	Biological Process		7
GO:0048861	leukemia inhibitory factor signaling pathway	Biological Process		2
GO:0008283	cell proliferation	Biological Process	TAS[7738033]	60
GO:0008284	positive regulation of cell proliferation	Biological Process	TAS[7862649]	69
GO:0007399	nervous system development	Biological Process	TAS[7738033]	54
GO:0007517	muscle organ development	Biological Process	TAS[8833032]	16
GO:0005615	extracellular space	Cellular Component		126
GO:0007267	cell-cell signaling	Biological Process	TAS[7862649]	38
GO:0005146	leukemia inhibitory factor receptor binding	Molecular Function		1
GO:0005576	extracellular region	Cellular Component	TAS[7862649]	240
GO:0005125	cytokine activity	Molecular Function		19

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04060	Cytokine-cytokine receptor interaction	38	Cytokines are soluble extracellular proteins or glycoprotein...... Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. More...
hsa04630	Jak-STAT signaling pathway	22	The Janus kinase/signal transducers and activators of transc...... The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors. More...

Genes shared at least 5 GO terms with CTF1 (count: 2)

Gene Symbol	Pathway Count	Pathway List
ACHE	5	cell proliferation; nervous system development; muscle organ development; extracellular space; extracellular region;
VEGFA	5	positive regulation of cell proliferation; nervous system development; extracellular space; extracellular region; cytokine activity;

Genes shared at least 2 KEGG pathways with CTF1 (count: 16)

Gene Symbol	Pathway Count	Pathway List
CLCF1	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
CNTF	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
CNTFR	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
GHR	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IFNGR1	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL10RA	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL11RA	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL12B	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL20RA	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL22RA2	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL5RA	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL6	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL7R	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
LIFR	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
OSMR	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
PRLR	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;

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Region: chr16:30904374..30914881 View in gBrowse