ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0043123
Name	positive regulation of I-kappaB kinase/NF-kappaB cascade
Type	Biological Process
No. of Genes in ADHDgene	27
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 27)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	6q25.2-q27	1(1/0/0)	IDA[19880420]

Genes from other sources (count: 26)

Approved Symbol	Approved Name	Source	Evidence[PMID]
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	Mapped by significant region	IEP[12761501]
UBC	ubiquitin C	Mapped by CNV
NUP62	nucleoporin 62kDa	Mapped by PBA pathway	IDA[10356400]
TNFRSF11A	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	Mapped by CNV	RCA[19641626]
MAVS	mitochondrial antiviral signaling protein	Mapped by CNV	IMP[12761501]
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	Mapped by significant region	IMP[12761501]
TERF2IP	telomeric repeat binding factor 2, interacting protein	Mapped by significant region
TLR4	toll-like receptor 4	Mapped by significant region
APOL3	apolipoprotein L, 3	Mapped by CNV	IMP[12761501]
NEK6	NIMA (never in mitosis gene a)-related kinase 6	Mapped by significant region	IMP[12761501]
TRAF1	TNF receptor-associated factor 1	Mapped by significant region	RCA[19641626]
TRIM13	tripartite motif containing 13	Mapped by LD-proxy	IMP[12761501]
PRKCB	protein kinase C, beta	Mapped by significant region
RNF31	ring finger protein 31	Mapped by significant region
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	Mapped by significant region	IMP[19509286]
GJA1	gap junction protein, alpha 1, 43kDa	Mapped by significant region	IMP[12761501]
FADD	Fas (TNFRSF6)-associated via death domain	Mapped by significant region	IEP[12761501]
TRIM5	tripartite motif containing 5	Mapped by CNV
PRKD1	protein kinase D1	Mapped by significant region	IMP[12505989]
CCL19	chemokine (C-C motif) ligand 19	Mapped by LD-proxy	IDA[15059845]
BIRC3	baculoviral IAP repeat containing 3	Mapped by significant region
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mapped by significant region	IEP[12761501]
EEF1D	eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)	Mapped by LD-proxy; Mapped by literature SNP	IMP[12761501]
BIRC2	baculoviral IAP repeat containing 2	Mapped by significant region	IEP[12761501]
LPAR1	lysophosphatidic acid receptor 1	Mapped by significant region	IEP[12761501]
UBB	ubiquitin B	Mapped by significant region