ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CCL19
Previous Symbol	SCYA19
Symbol Alias	ELC, MIP-3b, exodus-3, CKb11
Approved Name	chemokine (C-C motif) ligand 19
Previous Name	small inducible cytokine subfamily A (Cys-Cys), member 19
Name Alias	CC chemokine ligand 19, "macrophage inflammatory protein 3-beta", "beta chemokine exodus-3", "CK beta-11", "EBI1-ligand chemokine"
Location	9p13
Position	chr9:34689564-34691274, -
External Links	HGNC: 10617 Entrez Gene: 6363 Ensembl: ENSG00000172724 UCSC: uc003zvn.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 2)

Literature-origin SNPs (count: 0)

LD-proxies (count: 2)

rs_ID	Location	Functional Annotation
rs3176818	Chr9:34687936(Fwd)	downstream_gene_variant
rs3176813	Chr9:34690811(Fwd)	intron_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 48)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 48)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0050718	positive regulation of interleukin-1 beta secretion	Biological Process		5
GO:0048469	cell maturation	Biological Process		6
GO:0048260	positive regulation of receptor-mediated endocytosis	Biological Process		3
GO:0048020	CCR chemokine receptor binding	Molecular Function		1
GO:0060491	regulation of cell projection assembly	Biological Process		1
GO:0051897	positive regulation of protein kinase B signaling cascade	Biological Process	IDA[15778365]	17
GO:0051209	release of sequestered calcium ion into cytosol	Biological Process	IDA[14592837]	9
GO:0050921	positive regulation of chemotaxis	Biological Process		3
GO:0090023	positive regulation of neutrophil chemotaxis	Biological Process		5
GO:0072610	interleukin-12 secretion	Biological Process		1
GO:0071731	response to nitric oxide	Biological Process	IDA[16249377]	1
GO:0070374	positive regulation of ERK1 and ERK2 cascade	Biological Process	IDA[15778365]	22
GO:2000549	positive regulation of dendritic cell dendrite assembly	Biological Process		1
GO:2000147	positive regulation of cell motility	Biological Process	IDA[15778365]	2
GO:2000107	negative regulation of leukocyte apoptotic process	Biological Process	IDA[15059845]	2
GO:0097029	mature dendritic cell differentiation	Biological Process		1
GO:0032735	positive regulation of interleukin-12 production	Biological Process		7
GO:0032760	positive regulation of tumor necrosis factor production	Biological Process		9
GO:0034695	response to prostaglandin E stimulus	Biological Process	IDA[14592837]	1
GO:0042102	positive regulation of T cell proliferation	Biological Process		11
GO:0031295	T cell costimulation	Biological Process		12
GO:0031732	CCR7 chemokine receptor binding	Molecular Function		1
GO:0031735	CCR10 chemokine receptor binding	Molecular Function	IDA[10706668]	1
GO:0032320	positive regulation of Ras GTPase activity	Biological Process		5
GO:0045627	positive regulation of T-helper 1 cell differentiation	Biological Process		1
GO:0045807	positive regulation of endocytosis	Biological Process		6
GO:0045860	positive regulation of protein kinase activity	Biological Process	IDA[14592837]	7
GO:0046330	positive regulation of JNK cascade	Biological Process	IDA[15778365]	12
GO:0042346	positive regulation of NF-kappaB import into nucleus	Biological Process	IDA[15059845]	4
GO:0043089	positive regulation of Cdc42 GTPase activity	Biological Process		2
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	Biological Process	IDA[15059845]	27
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	Biological Process	IDA[15778365]	1
GO:0005576	extracellular region	Cellular Component		240
GO:0002606	positive regulation of dendritic cell antigen processing and presentation	Biological Process		2
GO:0006874	cellular calcium ion homeostasis	Biological Process	TAS[9153236]	16
GO:0005615	extracellular space	Cellular Component		126
GO:0001771	immunological synapse formation	Biological Process		1
GO:0001768	establishment of T cell polarity	Biological Process	IDA[12729902]	1
GO:0002408	myeloid dendritic cell chemotaxis	Biological Process	IDA[14592837]	1
GO:0002407	dendritic cell chemotaxis	Biological Process	IDA[15778365]	5
GO:0009615	response to virus	Biological Process	TAS[9153236]	21
GO:0008009	chemokine activity	Molecular Function	IDA[15778365]	4
GO:0014070	response to organic cyclic compound	Biological Process		7
GO:0010560	positive regulation of glycoprotein biosynthetic process	Biological Process		1
GO:0006955	immune response	Biological Process		45
GO:0006954	inflammatory response	Biological Process	NAS[14592837]	51
GO:0007257	activation of JUN kinase activity	Biological Process		8
GO:0007154	cell communication	Biological Process	TAS[9153236]	10

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04062	Chemokine signaling pathway	32	Inflammatory immune response requires the recruitment of leu...... Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival. More...
hsa04060	Cytokine-cytokine receptor interaction	38	Cytokines are soluble extracellular proteins or glycoprotein...... Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. More...

Genes shared at least 5 GO terms with CCL19 (count: 8)

Gene Symbol	Pathway Count	Pathway List
TIRAP	7	positive regulation of neutrophil chemotaxis; positive regulation of ERK1 and ERK2 cascade; positive regulation of interleukin-12 production; positive regulation of tumor necrosis factor production; positive regulation of JNK cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; inflammatory response;
TLR4	7	positive regulation of ERK1 and ERK2 cascade; positive regulation of interleukin-12 production; positive regulation of tumor necrosis factor production; positive regulation of JNK cascade; positive regulation of NF-kappaB import into nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; immune response;
CXCL12	7	negative regulation of leukocyte apoptotic process; extracellular region; cellular calcium ion homeostasis; extracellular space; response to virus; chemokine activity; immune response;
PYCARD	6	positive regulation of interleukin-1 beta secretion; positive regulation of ERK1 and ERK2 cascade; positive regulation of tumor necrosis factor production; positive regulation of JNK cascade; extracellular region; inflammatory response;
IL6	6	positive regulation of protein kinase B signaling cascade; positive regulation of ERK1 and ERK2 cascade; positive regulation of T cell proliferation; extracellular region; extracellular space; inflammatory response;
C5	6	positive regulation of chemotaxis; extracellular region; cellular calcium ion homeostasis; extracellular space; chemokine activity; inflammatory response;
IL12B	5	positive regulation of interleukin-12 production; positive regulation of tumor necrosis factor production; positive regulation of T cell proliferation; positive regulation of NF-kappaB import into nucleus; extracellular space;
IL18	5	positive regulation of tumor necrosis factor production; extracellular region; extracellular space; immune response; inflammatory response;

Genes shared at least 2 KEGG pathways with CCL19 (count: 6)

Gene Symbol	Pathway Count	Pathway List
CCL27	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
CCR5	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
CXCL12	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
CXCR1	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
CXCR2	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
CXCR5	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;

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Region: chr9:34689564..34691274 View in gBrowse