ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Study Report

Basic Info

Reference	Li J, 200817918234
Citation	Li J., Wang Y., Hu S., Zhou R., Yu X., Wang B., Guan L., Yang L., Zhang F. and Faraone S. V. (2008) "The monoamine oxidase B gene exhibits significant association to ADHD." Am J Med Genet B Neuropsychiatr Genet, 147(3): 370-4.
Study Design	family-based
Study Type	Candidate-gene association study
Sample Size	548 ADHD probands
Predominant Ethnicity	Mongoloid
Population	China
Age Group	Children/Adolescents : mean age 10.0,SD=2.9 years

Detail Info

Summary	The current study sequenced the exons and the 5' and 3' flanking regions of the MAOB gene and found four common variants including 2276C>T and 2327C>T in exon 15, rs1799836 in intron 13 and rs1040399 in 3'-UTR. They assessed the association of these variants with ADHD in 548 trios collected from 468 males and 80 females probands. TDT analysis showed that alleles of each polymorphism were preferentially transmitted to probands (rs1799836, P-value=3.28E-15; rs1040399, P-value=1.87E-6; 2276T>C or 2327T>C, P-value=2.20E-6) and haplotype-based TDT analyses also found distorted transmission. In conclusion, this study provides the strongest evidence for the involvement of MAOB gene in the etiology of ADHD to date, at least in Han Chinese population.
Total Sample	548 ADHD probands were recruited from the ADHD outpatient clinic at the Child and Adolescent Psychiatry Division of the Sixth Hospital, Peking University in Beijing, PRC.
Sample Collection	Han Chinese descent
Diagnosis Description	All probands fulfilled DSM-IV diagnostic criteria for ADHD based on interviews by at least two different child psychiatrists with the aid of information from both biological parents and teachers. Of the 548 ADHD probands, 223 (40.7%) probands met criteria for ADHD combined type (ADHD-C), 30 (5.5%) met criteria for ADHD hyperactive-impulsive type (ADHD-HI) and 295 (53.8%) met criteria forADHDinattentive type (ADHD-I).
Technique	The promoter region, 15 exons and exon-intron junctions and partial sequences of 3' UTR were amplified by polymerase chain reaction (PCR) with primers given in the original publication. Variants of interest detected in this study were genotyped by restriction fragment length polymorphism (RFLP) in 548 ADHD trios. The method for genotyping these variants were given in Table II of the original publication.
Analysis Method	Linkage disequilibrium (LD) between variants was estimated by the EH program. The Transmission Disequilibrium Test (TDT) and the extended Transmission Disequilibrium Test (ETDT) were performed to test for distorted transmission of alleles or haplotypes. Holm's sequential Bonferroni procedure was used to correct for multiple testing.
Result Description	TDT analysis showed that alleles of each polymorphism were preferentially transmitted to probands (rs1799836, P-value=3.28E-15; rs1040399, P-value=1.87E-6; 2276T>C or 2327T>C, P-value=2.20E-6) and haplotype-based TDT analyses also found distorted transmission.

SNPs reported by this study (count: 2)

SNP	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
rs1799836	A/G		TDT P-value=3.28E-15, X²=62.09	significantly biased transmitted to ADHD offspring significantly biased transmitted to ADHD offspring	Significant
rs1040399	C/T		TDT P-value=1.87E-6, X²=22.72	significantly biased transmitted to ADHD offspring significantly biased transmitted to ADHD offspring	Significant

Other variant reported by this study (count: 2)

Variant Name	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
MAOB exon15 2327T>C	C/T		TDT P-value=2.20E-6, X²=20.65 TDT P-value=2.20E-6, X²=20.65	significantly biased transmitted to ADHD offspring	Significant
MAOB exon15 2276T>C	C/T		TDT P-value=2.20E-6, X²=20.65 TDT P-value=2.20E-6, X²=20.65	significantly biased transmitted to ADHD offspring	Significant

Genes reported by this study (count: 1)