ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Study Report

Basic Info

Reference	Bruggemann D, 200717413453
Citation	Bruggemann D., Sobanski E., Alm B., Schubert T., Schmalzried H., Philipsen A., Breen G., Becker T., Georgi A., Skowronek M. H., Schulze T. G., Treutlein J. and Rietschel M. (2007) "No association between a common haplotype of the 6 and 10-repeat alleles in intron 8 and the 3'UTR of the DAT1 gene and adult attention deficit hyperactivity disorder." Psychiatr Genet, 17(2): 121.
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	122 patients and 174 controls
Predominant Ethnicity	Caucasian
Population	Germany
Age Group	Adults

Detail Info

Summary	They tested the association between these variants and ADHD in a sample of 122 adult ADHD patients and 174 community-based controls, all of German descent. No association was found, neither when testing single markers nor haplotypes. Their results thus do not support an association with ADHD in adults from the German population for either the 30-bp VNTR of intron 8 nor for the 40-bp VNTR in the 3' untranslated region.
Total Sample	The sample comprised of 122 adult ADHD patients and 174 community-based controls, all of German descent.
Sample Collection	The sample comprised of 122 adult ADHD patients and 174 community-based controls, all of German descent.
Diagnosis Description	no description in the original publication
Technique	no description in the original publication
Analysis Method	no description in the original publication
Result Description	No association was found, neither when testing single markers nor haplotypes. The allele frequencies for the 6r allele of the 30-bp VNTR were 79% in cases vs. 79.8% in controls. The allele frequencies for the 10r allele were 72.2% in cases and 74.6% in controls. The frequencies for the 6-10 haplotype were 68.7 in cases and 70.4% in controls. Likewise, no differential distributions of alleles nor haplotypes were observed, when cases were stratified according to their clinical subtype (inattentive vs. mixed inattentive-hyperactive).

Other variant reported by this study (count: 2)

Variant Name	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
SLC6A3 intron8 VNTR			no P-value no P-value	no association was found when testing single markers	Non-significant
SLC6A3 3'-UTR VNTR			no P-value no P-value	no association was found when testing single markers	Non-significant

Genes reported by this study (count: 1)