ADHDgene Database

SNP Report

Basic Info

Name	rs6582081 dbSNP Ensembl
Location	Chr12:72383614(Fwd)
Variant Alleles	A/G
Ancestral Allele	G
Functional Annotation	intron_variant.
Consequence to Transcript	intron_variant(ENST00000333850)
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Brookes K, 2006	A/G		UNPHASED TDT P-value=0.00398; WHAP TDT P-value=0.010 UNPHASED TDT P-value=0.00398; WHAP TDT P-value=0.010	significant association was observed in both UNPHASED and WH...... significant association was observed in both UNPHASED and WHAP analyses More...	Significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
TPH2	tryptophan hydroxylase 2	12q15	10(7/3/0)

SNPs in LD with rs6582081 (count: 26) View in gBrowse (chr12:72348698..72398117 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs1386497	intron_variant	2(1/1/0)	0.913[CEU]; 0.917[CHD]; 0.89[TSI]
rs6582072	NMD_transcript_variant; intron_variant	1(0/1/0)	0.937[ASW]
rs4760814	intron_variant	1(0/1/0)	0.913[CEU]; 0.846[CHB]
rs1386493	NMD_transcript_variant; intron_variant	4(2/2/0)	1.0[ASW]
rs1386496	NMD_transcript_variant; intron_variant	2(0/2/0)	0.831[CEU]; 0.846[CHB]; 1.0[CHD]; 1.0[GIH]; 0.859[MEX]; 1.0[TSI]
rs1007023	intron_variant	1(1/0/0)	0.913[CEU]; 0.846[CHB]; 1.0[CHD]; 1.0[GIH]; 0.859[MEX]; 0.96[TSI]
rs1386494	NMD_transcript_variant; intron_variant	1(0/1/0)	0.831[CEU]; 0.846[CHB]
rs1843809	NMD_transcript_variant; intron_variant	5(3/2/0)	0.831[CEU]; 0.846[CHB]; 0.846[CHD]; 0.883[GIH]; 1.0[TSI]
rs4760818	intron_variant	2(1/1/0)	0.913[CEU]; 0.935[GIH]; 0.858[MEX]
rs7954568	intron_variant	1(1/0/0)	0.906[CEU]; 0.846[CHB]
rs7963226	intron_variant	1(1/0/0)	1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[TSI]

rs_ID	Functional Annotation	r²[population]
rs1487281	intron_variant	0.913[CEU]; 0.846[CHB]; 1.0[CHD]; 1.0[GIH]; 0.86[MEX]; 1.0[TSI]
rs10784942	NMD_transcript_variant; intron_variant	0.831[CEU]; 0.846[CHB]
rs7968346	NMD_transcript_variant; intron_variant	0.831[CEU]; 0.846[CHB]
rs4760749	NMD_transcript_variant; intron_variant	0.831[CEU]; 0.846[CHB]
rs1386490	NMD_transcript_variant; intron_variant	0.846[CHB]
rs1843812	intron_variant	0.913[CEU]; 0.846[CHB]; 1.0[CHD]; 1.0[GIH]; 0.859[MEX]; 0.96[TSI]
rs1386489	NMD_transcript_variant; intron_variant	0.831[CEU]; 0.846[CHB]; 0.846[CHD]; 0.883[GIH]; 0.859[MEX]; 1.0[TSI]
rs10784944	downstream_gene_variant; intron_variant	0.831[CEU]; 0.846[CHB]; 0.846[CHD]; 0.871[GIH]; 0.851[MEX]; 1.0[TSI]
rs2046582	intron_variant	0.912[CEU]; 0.846[CHB]
rs2367899	intron_variant	0.913[CEU]; 0.846[CHB]
rs10748189	intron_variant	0.831[CEU]; 0.846[CHB]
rs4760751	intron_variant	0.913[CEU]; 0.846[CHB]; 1.0[CHD]; 1.0[GIH]; 0.859[MEX]; 1.0[TSI]
rs990234	intron_variant	0.831[CEU]
rs7300490	intron_variant	0.913[CEU]
rs7299582	3_prime_UTR_variant; NMD_transcript_variant; intron_variant	0.831[CEU]; 0.846[CHB]; 0.846[CHD]; 0.883[GIH]; 0.859[MEX]; 1.0[TSI]