ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

SNP Report

Basic Info

Name	rs6539445 dbSNP Ensembl
Location	Chr12:79763394(Fwd)
Variant Alleles	G/A
Ancestral Allele	G
Functional Annotation	intron_variant; nc_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000457153; ENST00000261205; ENST00000393240; ENST00000549527; ENST00000552744) nc_transcript_variant(ENST00000549527)
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Sanchez-Mora, C., 2012			P-value=0.008, Genotype12+22 vs11: P-value=0.020, OR(95%CI)=...... P-value=0.008, Genotype12+22 vs11: P-value=0.020, OR(95%CI)=1.35(1.05¨C1.75); Genotypes22 vs11+12: P-value=0.010, OR(95%CI)=2.89(1.27¨C6.57); allelic P-value=0,005, OR(95%CI)=1.37(1.10¨C1.72) More...	Nine SNPs located in five genes displayed nominal associatio...... Nine SNPs located in five genes displayed nominal associations in the comparison of ADHD children and controls More...	Significant

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
SYT1	synaptotagmin I	12cen-q21	4(2/2/0)

Genes from other sources (count: 0)

SNPs in LD with rs6539445 (count: 25) View in gBrowse (chr12:79759364..79958118 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 25)

rs_ID	Functional Annotation	r²[population]
rs11114027	intron_variant; nc_transcript_variant	1.0[ASW]; 0.805[CEU]; 1.0[CHB]; 1.0[CHD]; 0.908[GIH]; 1.0[JPT]; 1.0[YRI]
rs11114116	intron_variant; nc_transcript_variant	0.846[JPT]
rs11114122	downstream_gene_variant; intron_variant; nc_transcript_variant	0.888[CHB]; 0.849[CHD]; 0.846[JPT]
rs11114107	intron_variant; nc_transcript_variant	0.846[JPT]; 1.0[YRI]
rs11114143		0.845[CHB]
rs11113987	intron_variant; nc_transcript_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 0.849[YRI]
rs17229687	upstream_gene_variant	0.888[CHB]; 0.849[CHD]; 0.846[JPT]
rs955574		0.877[CHB]
rs11114174		0.849[CHD]; 0.846[JPT]
rs7954927	intron_variant; nc_transcript_variant	0.846[JPT]; 1.0[YRI]
rs1553525		0.888[CHB]; 0.849[CHD]; 0.846[JPT]; 0.828[LWK]
rs7315113	intron_variant; nc_transcript_variant	0.846[JPT]; 0.825[YRI]
rs12229260	downstream_gene_variant	0.846[JPT]
rs7295198	intron_variant; nc_transcript_variant; upstream_gene_variant	0.888[CHB]; 0.849[CHD]; 0.846[JPT]
rs11113980	intron_variant; nc_transcript_variant	0.922[CEU]; 1.0[YRI]
rs11114145		0.888[CHB]; 0.846[JPT]
rs7308762	upstream_gene_variant	0.849[CHD]; 0.846[JPT]
rs11114146		0.821[CHB]
rs10861990	downstream_gene_variant	0.888[CHB]; 0.846[JPT]
rs17294719	intron_variant; nc_transcript_variant; upstream_gene_variant	0.846[JPT]
rs12227728	upstream_gene_variant	0.846[JPT]
rs11114133	intron_variant; nc_transcript_variant	0.846[JPT]
rs11114148		0.877[CHB]; 0.822[JPT]
rs7135647	intron_variant; nc_transcript_variant	0.846[JPT]
rs11114112	intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[ASW]; 0.923[CHD]; 0.908[GIH]; 0.846[JPT]; 1.0[YRI]