ADHDgene Database

SNP Report

Basic Info

Name	rs1491850 dbSNP Ensembl
Location	Chr11:27749725(Fwd)
Variant Alleles	T/C
Ancestral Allele	T
Functional Annotation	intron_variant; nc_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000530663) nc_transcript_variant(ENST00000530663)
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Ribases M, 2008			genotypic P-value=0.11; genotypic P-value=0.05, OR=1.42 (1.0...... genotypic P-value=0.11; genotypic P-value=0.05, OR=1.42 (1.00-2.02) in dominant model; genotypic P-value=0.18 in recessive model; allelic P-value=0.04, OR=1.26 (1.01-1.59) in Adults; genotypic P-value=0.12; genotypic P-value=0.057 in dominant model; genotypic P-value=0.15 in recessive model; allelic P-value=0.037, OR=1.24 (1.01-1.51) in Children More...	provided evidence of association with adulthood and childhoo...... provided evidence of association with adulthood and childhood ADHD More...	Significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
BDNF	brain-derived neurotrophic factor	11p14.1	14(8/6/0)

SNPs in LD with rs1491850 (count: 21) View in gBrowse (chr11:27572337..27749725 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs6265	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; missense_variant; nc_transcript_variant; non_coding_exon_variant	12(3/9/0)	0.838[CHD]; 1.0[JPT]
rs10767664	intron_variant; nc_transcript_variant; upstream_gene_variant	1(1/0/0)	1.0[JPT]
rs7103411	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	2(2/0/0)	0.861[CHD]; 1.0[JPT]
rs11030104	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	2(1/1/0)	0.836[CHD]; 1.0[JPT]

rs_ID	Functional Annotation	r²[population]
rs10835193	intron_variant; nc_transcript_variant	0.814[CEU]
rs16917237	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	0.861[CHD]; 1.0[JPT]
rs4074134	intron_variant; nc_transcript_variant	0.848[JPT]
rs4923460	intron_variant; nc_transcript_variant; upstream_gene_variant	0.848[JPT]
rs7934165	intron_variant; nc_transcript_variant	0.801[CHD]
rs10767665	intron_variant; nc_transcript_variant	0.823[CHD]
rs4923461	intron_variant; nc_transcript_variant; upstream_gene_variant	0.848[JPT]
rs6484320	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	1.0[JPT]
rs11030048	intron_variant; nc_transcript_variant	0.803[CEU]
rs12419948	intron_variant; nc_transcript_variant	0.814[CHB]; 0.95[JPT]
rs988748	intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[JPT]
rs11030084	intron_variant; nc_transcript_variant	0.839[JPT]
rs2030323	intron_variant; nc_transcript_variant	1.0[JPT]
rs10501087	intron_variant; nc_transcript_variant	0.814[CHB]; 0.862[CHD]; 0.95[JPT]
rs4923457	intron_variant; nc_transcript_variant	0.848[JPT]
rs925947	intron_variant; nc_transcript_variant	0.801[CHB]; 0.949[JPT]
rs7931247	intron_variant; nc_transcript_variant; upstream_gene_variant	0.848[CHD]