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KEGG Pathway Report
Basic Info
| ID | hsa03320 |
|---|---|
| Name | PPAR signaling pathway |
| Description | Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake. |
| No. of Genes in ADHDgene | 12 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 12)
Literature-origin genes (count: 2)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| FADS2 | fatty acid desaturase 2 | 11q12.2 | 3(3/0/0) |
| LPL | lipoprotein lipase | 8p22 | 1(0/0/1) |
Genes from other sources (count: 10)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| CYP27A1 | cytochrome P450, family 27, subfamily A, polypeptide 1 | 2q33-qter | Mapped by significant region |
| MMP1 | matrix metallopeptidase 1 (interstitial collagenase) | 11q21-q22 | Mapped by significant region |
| CPT1A | carnitine palmitoyltransferase 1A (liver) | 11q13.2 | Mapped by CNV; Mapped by significant region |
| APOA5 | apolipoprotein A-V | 11q23 | Mapped by significant region |
| FABP6 | fatty acid binding protein 6, ileal | 5q23-q35 | Mapped by significant region |
| FABP7 | fatty acid binding protein 7, brain | 6q22-q23 | Mapped by significant region |
| APOC3 | apolipoprotein C-III | 11q23-qter | Mapped by significant region |
| ILK | integrin-linked kinase | 11p15.4 | Mapped by CNV |
| APOA1 | apolipoprotein A-I | 11q23-q24 | Mapped by significant region |
| UBC | ubiquitin C | 12q24.3 | Mapped by CNV |