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KEGG Pathway Report
Basic Info
| ID | hsa00120 |
|---|---|
| Name | Primary bile acid biosynthesis |
| Description | Bile acids are steroid carboxylic acids derived from cholesterol in vertebrates. The primary bile acids, cholic acid and chenodeoxycholic acid, are synthesized in the liver and conjugated with taurine or glycine before secretion via bile into the intestine. The conversion from cholesterol to cholic and chenodeoxycholic acids involves four steps: 1) the initiation of synthesis by 7alpha-hydroxylation of sterol precursors, 2) further modifications to the ring structures, 3) side-chain oxidation and shortening (cleavage) by three carbons, and 4) conjugation of the bile acid with taurine or glycine. |
| No. of Genes in ADHDgene | 4 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 4)
Literature-origin genes (count: 0)
Genes from other sources 
(count: 4)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| CYP27A1 | cytochrome P450, family 27, subfamily A, polypeptide 1 | 2q33-qter | Mapped by significant region |
| BAAT | bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase) | 9q22.3 | Mapped by significant region |
| AMACR | alpha-methylacyl-CoA racemase | 5p13.2-q11.1 | Mapped by significant region |
| HSD3B7 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | 16p11.2 | Mapped by CNV |