ADHDgene Database
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Type:
  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Other Variant Report

Basic Info
Name DRD4_promoter_duplication_120bp
Type insertion/deletion
Location promoter
Length of Repeat Unit 120bp
Related Gene DRD4
No. of Study 13 (significant: 4; non-significant 9; trend: 0)

Variant related studies (count: 13)
Reference Allele Change Risk Allele Statistical Values Author Comments Result of Statistical Analysis
Bhaduri N, 2006 (a) 1 repeat/2 repeat HHRR P-value=0.351, X2=0.87, RR=0.87; TDT P-value...... HHRR P-value=0.351, X2=0.87, RR=0.87; TDT P-value=0.2733, X2=1.2 More... revealed lack of association revealed lack of association Non-significant
Brookes KJ, 2005 (a) 120bp allelic TDT P-value=0.71; HHRR P-value=0.73 allelic TDT P-value=0.71; HHRR P-value=0.73 global and allele-specific tests of association were non-sig...... global and allele-specific tests of association were non-significant More... Non-significant
Lowe N, 2004 (a) long TDT P-value=0.918, OR=1.04, 95% CI=0.70-1.56 TDT P-value=0.918, OR=1.04, 95% CI=0.70-1.56 no evidence no evidence Non-significant
Kirley A, 2004 allelic TDT P-value=1.0, X2=0.02 in combined subt...... allelic TDT P-value=1.0, X2=0.02 in combined subtype More... there was no association between this variant and DSM-IV com...... there was no association between this variant and DSM-IV combined type ADHD More... Non-significant
Sanchez-Mora C, 2011 chi-square test P-value>0.05 for allele and genotype frequen...... chi-square test P-value>0.05 for allele and genotype frequencies from each separate site; P-value=0.009, OR=1.69 between L allele and ADHD in males from Norway; P-value=0.04, OR=1.40; P-value=0.04, OR=2.63 in combined subtype in Norway and in Spain respectively; meta-analysis: P-value=0.30, OR=0.81 in dominant model (LS+LL vs. SS), P-value=0.52, OR=1.05 in recessive model (LL vs. LS+SS), P-value=0.80, OR=0.98 in overdominant model (LS vs. LL+SS) More... no significant association was detected for genotype and all...... no significant association was detected for genotype and allele frequencies between cases and controls from each separate site; a nominal association between the L allele of the dup120bp polymorphism and ADHD in males from Norway; nominal association was also observed in two samples from Norway and Spain in the combined clinical subtype; no significant association was found for dup120bp in the full ADHD sample in the meta-analysis More... Significant
Gizer IR, 2009 Meta-analysis model: Random: OR=1.05, 95% CI=0.86-1.31, two-...... Meta-analysis model: Random: OR=1.05, 95% CI=0.86-1.31, two-tailed P-value=0.59; Q-statistic: P-value=0.033, I2=54 More... no evidence to suggest an association between this polymorph...... no evidence to suggest an association between this polymorphisms and ADHD More... Non-significant
Kereszturi E, 2007 P-value=0.047 (df=1) for allelic distribution; P-value=0.019...... P-value=0.047 (df=1) for allelic distribution; P-value=0.019 (OR=2.71) for homozygote genotype analysis More... No association was found between ADHD and this polymorphism,...... No association was found between ADHD and this polymorphism, howerer, an overrepresentation of the 1-repeat form of the 120-bp dup was observed in the clinical group. More... Significant
Barr CL, 2001(d) 1/2 repeat allelic P-value=0.198, X2=1.658 allelic P-value=0.198, X2=1.658 there was a trend for the transmission of the allele with 1 ...... there was a trend for the transmission of the allele with 1 repeat, but this was not significant More... Non-significant
McCracken JT, 2000 120bp/240bp TDT P-value=0.02 for total sample, P-value=0.005 for sample ...... TDT P-value=0.02 for total sample, P-value=0.005 for sample of inatentive subtype, P-value=0.502 for sample of combined/HI subtypes. More... Results showed a significant preferential transmission of th...... Results showed a significant preferential transmission of the 240-bp (long) allele with ADHD. More... Significant
Arcos-Burgos M, 2004 (b) two-point LOD=-3.89 under model I, two-point LOD=-7.66 under...... two-point LOD=-3.89 under model I, two-point LOD=-7.66 under model II, two-point LOD=-3.7 under model III, NPL P-value=0.4231, PDT P-value=0.5835 More... Two-point LOD scores were significantly negative; Non-parame...... Two-point LOD scores were significantly negative; Non-parametrical analysis resulted in nonsignificant evidence for linkage More... Non-significant
Kustanovich V, 2004 GRR=1.37, TDT P-value=0.006 GRR=1.37, TDT P-value=0.006 displayed a significant bias in transmission of the insertio...... displayed a significant bias in transmission of the insertion More... Significant
Mill J, 2003 TRANSMIT P-value>0.05 TRANSMIT P-value>0.05 no evidence of biased transmission to ADHD probands was foun...... no evidence of biased transmission to ADHD probands was found More... Non-significant
Todd RD, 2001(b) ETDT P-value=0.47, X2(2df)=1.5 in DSM-IV inattent...... ETDT P-value=0.47, X2(2df)=1.5 in DSM-IV inattentive, ETDT P-value=0.50, X2(1df)=0.4 in DSM-IV combined, ETDT P-value=1.00, X2(1df)=0 in DSM-IV hyperactive/impulsive, ETDT P-value=0.38, X2(2df)=2.0 in DSM-IV any ADHD; allele-wise P-value=0.44, corrected P-value=0.69 for Allele 1, allele-wise P-value=0.39, corrected P-value=0.63 for Allele 2 in DSM-IV any ADHD; allele-wise P-value=0.71, corrected P-value=0.92 for Allele 1, allele-wise P-value=0.63, corrected P-value=0.86 for Allele 2 in DSM-IV inattentive; allele-wise P-value=0.51, corrected P-value=0.76 for Allele 1 and Allele 2 in DSM-IV combined; allele-wise P-value=1.00, corrected P-value=1.00 for Allele 1 and Allele 2 in DSM-IV hyperactive/impulsive More... there was no evidence for biased transmission of any allele ...... there was no evidence for biased transmission of any allele for either polymorphism for the DSM-IV-defined ADHD subtypes More... Non-significant

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014