ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TCF21
Symbol Alias	POD1, bHLHa23
Approved Name	transcription factor 21
Location	6q23-q24
Position	chr6:134210259-134216691, +
External Links	HGNC: 11632 Entrez Gene: 6943 Ensembl: ENSG00000118526 UCSC: uc003qei.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2010]_70	chr6:134200493-134257472 (NCBI Build 35 (hg17))	56980	6q23.2	Deletion (hemizygous)	Maternal

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
6q22-23	chr6:114600000-139000000	1 (1/0/0)

Gene related GO terms (count: 34)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 34)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0001657	ureteric bud development	Biological Process		4
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	Molecular Function	IDA[12493738]	7
GO:0001763	morphogenesis of a branching structure	Biological Process		3
GO:0001658	branching involved in ureteric bud morphogenesis	Biological Process		8
GO:0001944	vasculature development	Biological Process		3
GO:0001822	kidney development	Biological Process		16
GO:0007530	sex determination	Biological Process		2
GO:0005634	nucleus	Cellular Component	IDA[12493738]	770
GO:0030855	epithelial cell differentiation	Biological Process		7
GO:0014707	branchiomeric skeletal muscle development	Biological Process		1
GO:0042826	histone deacetylase binding	Molecular Function		10
GO:0032835	glomerulus development	Biological Process		2
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process		131
GO:0043425	bHLH transcription factor binding	Molecular Function	IPI[12493738]	2
GO:0048286	lung alveolus development	Biological Process		5
GO:0046983	protein dimerization activity	Molecular Function		26
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[12493738]	78
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	Molecular Function		8
GO:0070888	E-box binding	Molecular Function		4
GO:0060766	negative regulation of androgen receptor signaling pathway	Biological Process		2
GO:0072277	metanephric glomerular capillary formation	Biological Process		1
GO:0072162	metanephric mesenchymal cell differentiation	Biological Process		1
GO:0060435	bronchiole development	Biological Process		2
GO:0060426	lung vasculature development	Biological Process		3
GO:0060541	respiratory system development	Biological Process		1
GO:0060539	diaphragm development	Biological Process		1
GO:0060008	Sertoli cell differentiation	Biological Process		2
GO:0050681	androgen receptor binding	Molecular Function		10
GO:0060425	lung morphogenesis	Biological Process		1
GO:0060021	palate development	Biological Process		5
GO:0048557	embryonic digestive tract morphogenesis	Biological Process		7
GO:0048536	spleen development	Biological Process		5
GO:0048732	gland development	Biological Process		2
GO:0048608	reproductive structure development	Biological Process		1

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with TCF21 (count: 7)

Gene Symbol	Pathway Count	Pathway List
TFAP2A	8	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; kidney development; nucleus; positive regulation of transcription from RNA polymerase II promoter; protein dimerization activity; negative regulation of transcription from RNA polymerase II promoter; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; palate development;
FOXF1	7	morphogenesis of a branching structure; nucleus; positive regulation of transcription from RNA polymerase II promoter; lung alveolus development; negative regulation of transcription from RNA polymerase II promoter; lung vasculature development; embryonic digestive tract morphogenesis;
FOXC2	5	ureteric bud development; nucleus; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription;
HES1	5	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; nucleus; histone deacetylase binding; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter;
HNF1B	5	kidney development; nucleus; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; embryonic digestive tract morphogenesis;
HEY2	5	nucleus; histone deacetylase binding; positive regulation of transcription from RNA polymerase II promoter; protein dimerization activity; negative regulation of transcription from RNA polymerase II promoter;
NRIP1	5	nucleus; histone deacetylase binding; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; androgen receptor binding;

Genes shared at least 2 KEGG pathways with TCF21 (count: 0)

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Region: chr6:134210259..134216691 View in gBrowse