ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TAPBP
Symbol Alias	TAPA
Approved Name	TAP binding protein (tapasin)
Location	6p21.3
Position	chr6:33267471-33282164, -
External Links	HGNC: 11566 Entrez Gene: 6892 UCSC: uc003odx.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 2)

Literature-origin SNPs (count: 0)

LD-proxies (count: 2)

rs_ID	Location	Functional Annotation
rs3106191	Chr6:33280505(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs2282851	Chr6:33280309(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 23)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 23)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006955	immune response	Biological Process	TAS[9271576]	45
GO:0006952	defense response	Biological Process		5
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	Biological Process	NAS[11884415]	16
GO:0071556	integral to lumenal side of endoplasmic reticulum membrane	Cellular Component		3
GO:0006461	protein complex assembly	Biological Process	TAS[9271576]	28
GO:0051082	unfolded protein binding	Molecular Function	TAS[12788224]	19
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IDA[11884415]	140
GO:0050823	peptide antigen stabilization	Biological Process		1
GO:0005783	endoplasmic reticulum	Cellular Component	TAS[9238042]	100
GO:0046979	TAP2 binding	Molecular Function	IPI[12047747]; TAS[12788224]	1
GO:0005515	protein binding	Molecular Function	IPI[17055437]	910
GO:0046978	TAP1 binding	Molecular Function	IPI[12047747]; TAS[12788224]	1
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	Biological Process		14
GO:0042825	TAP complex	Cellular Component	IDA[17947644]	1
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	Biological Process		17
GO:0042824	MHC class I peptide loading complex	Cellular Component	NAS[12788224]	1
GO:0000139	Golgi membrane	Cellular Component	IDA[11884415]	95
GO:0042605	peptide antigen binding	Molecular Function	TAS[12788224]	4
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	Biological Process		14
GO:0042288	MHC class I protein binding	Molecular Function	TAS[12788224]	1
GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I	Biological Process		1
GO:0016021	integral to membrane	Cellular Component	TAS[9238042]	845
GO:0015433	peptide antigen-transporting ATPase activity	Molecular Function	TAS[9238042]	1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04612	Antigen processing and presentation	9

Genes shared at least 5 GO terms with TAPBP (count: 7)

Gene Symbol	Pathway Count	Pathway List
CANX	6	integral to lumenal side of endoplasmic reticulum membrane; unfolded protein binding; endoplasmic reticulum membrane; endoplasmic reticulum; protein binding; antigen processing and presentation of peptide antigen via MHC class I;
TMED10	5	retrograde vesicle-mediated transport, Golgi to ER; endoplasmic reticulum membrane; endoplasmic reticulum; protein binding; integral to membrane;
LMAN1	5	unfolded protein binding; endoplasmic reticulum membrane; protein binding; Golgi membrane; integral to membrane;
SREBF1	5	endoplasmic reticulum membrane; endoplasmic reticulum; protein binding; Golgi membrane; integral to membrane;
STX18	5	endoplasmic reticulum membrane; endoplasmic reticulum; protein binding; Golgi membrane; integral to membrane;
PDIA3	5	endoplasmic reticulum; protein binding; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I;
SEC61B	5	protein binding; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I; integral to membrane;

Genes shared at least 2 KEGG pathways with TAPBP (count: 0)

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Region: chr6:33267471..33282164 View in gBrowse