ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SPDYC
Symbol Alias	Ringo2
Approved Name	speedy homolog C (Xenopus laevis)
Location	11q13.1
Position	chr11:64937625-64940715, +
External Links	HGNC: 32681 Entrez Gene: 387778 Ensembl: ENSG00000204710 UCSC: uc010rnz.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 4)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005634	nucleus	Cellular Component		770
GO:0005737	cytoplasm	Cellular Component		690
GO:0007049	cell cycle	Biological Process		31
GO:0019901	protein kinase binding	Molecular Function	IPI[15611625]	51

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04114	Oocyte meiosis	22	During meiosis, a single round of DNA replication is followe...... During meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segregate to opposite poles, while the sister chromatids segregate from each other at meoisis II. In vertebrates, immature oocytes are arrested at the PI (prophase of meiosis I). The resumption of meiosis is stimulated by progesterone, which carries the oocyte through two consecutive M-phases (MI and MII) to a second arrest at MII. The key activity driving meiotic progression is the MPF (maturation-promoting factor), a heterodimer of CDC2 (cell division cycle 2 kinase) and cyclin B. In PI-arrested oocytes, MPF is initially inactive and is activated by the dual-specificity CDC25C phosphatase as the result of new synthesis of Mos induced by progesterone. MPF activation mediates the transition from the PI arrest to MI. The subsequent decrease in MPF levels, required to exit from MI into interkinesis, is induced by a negative feedback loop, where CDC2 brings about the activation of the APC (anaphase-promoting complex), which mediates destruction of cyclin B. Re-activation of MPF for MII requires re-accumulation of high levels of cyclin B as well as the inactivation of the APC by newly synthesized Emi2 and other components of the CSF (cytostatic factor), such as cyclin E or high levels of Mos. CSF antagonizes the ubiquitin ligase activity of the APC, preventing cyclin B destruction and meiotic exit until fertilization occurs. Fertilization triggers a transient increase in cytosolic free Ca2+, which leads to CSF inactivation and cyclin B destruction through the APC. Then eggs are released from MII into the first embryonic cell cycle. More...
hsa04914	Progesterone-mediated oocyte maturation	13	Xenopus oocytes are naturally arrested at G2 of meiosis I. E...... Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP. More...

Genes shared at least 5 GO terms with SPDYC (count: 0)

Genes shared at least 2 KEGG pathways with SPDYC (count: 8)

Gene Symbol	Pathway Count	Pathway List
ADCY4	2	Oocyte meiosis; Progesterone-mediated oocyte maturation;
ANAPC4	2	Oocyte meiosis; Progesterone-mediated oocyte maturation;
CDC26	2	Oocyte meiosis; Progesterone-mediated oocyte maturation;
INS	2	Oocyte meiosis; Progesterone-mediated oocyte maturation;
MAPK1	2	Oocyte meiosis; Progesterone-mediated oocyte maturation;
MAPK3	2	Oocyte meiosis; Progesterone-mediated oocyte maturation;
PGR	2	Oocyte meiosis; Progesterone-mediated oocyte maturation;
PLK1	2	Oocyte meiosis; Progesterone-mediated oocyte maturation;

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Region: chr11:64937625..64940715 View in gBrowse