ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SKP2
Symbol Alias	FBXL1, FBL1
Approved Name	S-phase kinase-associated protein 2 (p45)
Location	5p13
Position	chr5:36152091-36184421, +
External Links	HGNC: 10901 Entrez Gene: 6502 Ensembl: ENSG00000145604 UCSC: uc003jkc.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
5p13	chr5:28900000-42500000	3 (1/1/1)

Gene related GO terms (count: 18)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000209	protein polyubiquitination	Biological Process		23
GO:0000086	G2/M transition of mitotic cell cycle	Biological Process		29
GO:0000084	S phase of mitotic cell cycle	Biological Process		20
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process		26
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005515	protein binding	Molecular Function		910
GO:0004842	ubiquitin-protein ligase activity	Molecular Function		52
GO:0000278	mitotic cell cycle	Biological Process		63
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process		14
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IDA[16880511]	4
GO:0008283	cell proliferation	Biological Process	TAS[7553852]	60
GO:0005829	cytosol	Cellular Component		447
GO:0051726	regulation of cell cycle	Biological Process		8
GO:0048661	positive regulation of smooth muscle cell proliferation	Biological Process		5
GO:0042802	identical protein binding	Molecular Function		70
GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway	Biological Process		3
GO:0071460	cellular response to cell-matrix adhesion	Biological Process		1
GO:0000080	G1 phase of mitotic cell cycle	Biological Process		6

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04110	Cell cycle	19	Mitotic cell cycle progression is accomplished through a rep...... Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated. More...
hsa05222	Small cell lung cancer	16	Lung cancer is a leading cause of cancer death among men and...... Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% of all lung cancer cases. Molecular mechanisms altered in SCLC include induced expression of oncogene, MYC, and loss of tumorsuppressor genes, such as p53, PTEN, RB, and FHIT. The overexpression of MYC proteins in SCLC is largely a result of gene amplification. Such overexpression leads to more rapid proliferation and loss of terminal differentiation. Mutation or deletion of p53 or PTEN can lead to more rapid proliferation and reduced apoptosis. The retinoblastoma gene RB1 encodes a nuclear phosphoprotein that helps to regulate cell-cycle progression. The fragile histidine triad gene FHIT encodes the enzyme diadenosine triphosphate hydrolase, which is thought to have an indirect role in proapoptosis and cell-cycle control. More...
hsa04120	Ubiquitin mediated proteolysis	29	Protein ubiquitination plays an important role in eukaryotic...... Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates. More...
hsa05200	Pathways in cancer	52

Genes shared at least 5 GO terms with SKP2 (count: 20)

Gene Symbol	Pathway Count	Pathway List
UBB	9	protein polyubiquitination; S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; nucleoplasm; protein binding; mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cytosol; G1 phase of mitotic cell cycle;
UBC	9	protein polyubiquitination; S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; nucleoplasm; protein binding; mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cytosol; G1 phase of mitotic cell cycle;
PSMB7	8	protein polyubiquitination; S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; nucleoplasm; protein binding; mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cytosol;
PSMC3	8	protein polyubiquitination; S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; nucleoplasm; protein binding; mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cytosol;
PSMD5	8	protein polyubiquitination; S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; nucleoplasm; protein binding; mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cytosol;
PSMD7	8	protein polyubiquitination; S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; nucleoplasm; protein binding; mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cytosol;
PLK1	8	G2/M transition of mitotic cell cycle; nucleoplasm; protein binding; mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell proliferation; cytosol; regulation of cell cycle;
PSME1	7	protein polyubiquitination; S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; nucleoplasm; mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cytosol;
PSME2	7	protein polyubiquitination; S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; nucleoplasm; mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cytosol;
CCND1	7	S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; nucleoplasm; protein binding; mitotic cell cycle; cytosol; G1 phase of mitotic cell cycle;
ANAPC4	6	G2/M transition of mitotic cell cycle; nucleoplasm; ubiquitin-protein ligase activity; mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cytosol;
CDT1	6	S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; nucleoplasm; protein binding; mitotic cell cycle; cytosol;
BIRC2	5	protein polyubiquitination; protein binding; ubiquitin-protein ligase activity; cytosol; regulation of cell cycle;
PSMA8	5	protein polyubiquitination; S phase of mitotic cell cycle; mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cytosol;
MAPRE1	5	G2/M transition of mitotic cell cycle; protein binding; mitotic cell cycle; cell proliferation; cytosol;
NDE1	5	G2/M transition of mitotic cell cycle; protein binding; mitotic cell cycle; cytosol; identical protein binding;
NUMA1	5	G2/M transition of mitotic cell cycle; nucleoplasm; protein binding; mitotic cell cycle; cytosol;
CDC45	5	S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; nucleoplasm; protein binding; mitotic cell cycle;
RRM2	5	G1/S transition of mitotic cell cycle; nucleoplasm; protein binding; mitotic cell cycle; cytosol;
CDC26	5	nucleoplasm; protein binding; mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cytosol;

Genes shared at least 2 KEGG pathways with SKP2 (count: 19)

Gene Symbol	Pathway Count	Pathway List
CCND1	3	Cell cycle; Small cell lung cancer; Pathways in cancer;
BIRC2	3	Small cell lung cancer; Ubiquitin mediated proteolysis; Pathways in cancer;
BIRC3	3	Small cell lung cancer; Ubiquitin mediated proteolysis; Pathways in cancer;
ANAPC4	2	Cell cycle; Ubiquitin mediated proteolysis;
CDC26	2	Cell cycle; Ubiquitin mediated proteolysis;
GSK3B	2	Cell cycle; Pathways in cancer;
CYCS	2	Small cell lung cancer; Pathways in cancer;
FN1	2	Small cell lung cancer; Pathways in cancer;
ITGA2	2	Small cell lung cancer; Pathways in cancer;
LAMA2	2	Small cell lung cancer; Pathways in cancer;
LAMA3	2	Small cell lung cancer; Pathways in cancer;
LAMC1	2	Small cell lung cancer; Pathways in cancer;
LAMC2	2	Small cell lung cancer; Pathways in cancer;
PIK3CG	2	Small cell lung cancer; Pathways in cancer;
PIK3R1	2	Small cell lung cancer; Pathways in cancer;
RELA	2	Small cell lung cancer; Pathways in cancer;
TRAF1	2	Small cell lung cancer; Pathways in cancer;
CBL	2	Ubiquitin mediated proteolysis; Pathways in cancer;
TCEB1	2	Ubiquitin mediated proteolysis; Pathways in cancer;

View in gBrowse

Region: chr5:36152091..36184421 View in gBrowse