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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PNLIPRP1
Symbol Alias	PLRP1
Approved Name	pancreatic lipase-related protein 1
Location	10q26.12
Position	chr10:118349897-118368687, +
External Links	HGNC: 9156 Entrez Gene: 5407 Ensembl: ENSG00000187021 UCSC: uc001lco.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 7)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004091	carboxylesterase activity	Molecular Function		40
GO:0016298	lipase activity	Molecular Function	IDA[19824014]	49

GO terms by database search (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004806	triglyceride lipase activity	Molecular Function	TAS[1379598]	10
GO:0005509	calcium ion binding	Molecular Function		124
GO:0005576	extracellular region	Cellular Component	TAS[1379598]	240
GO:0005615	extracellular space	Cellular Component	IDA[19824014]	126
GO:0006629	lipid metabolic process	Biological Process		51

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04972	Pancreatic secretion	30	The pancreas performs both exocrine and endocrine functions....... The pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesize and secrete digestive enzymes. Stimulation of the cell by secretagogues such as acetylcholine (ACh) and cholecystokinin (CCK) causes the generation of an intracellular Ca2+ signal. This signal, in turn, triggers the fusion of the zymogen granules with the apical plasma membrane, leading to the polarised secretion of the enzymes. The major task of pancreatic duct cells is the secretion of fluid and bicarbonate ions (HCO3-), which neutralize the acidity of gastric contents that enter the duodenum. An increase in intracellular cAMP by secretin is one of the major signals of pancreatic HCO3- secretion. Activation of the CFTR Cl- channel and the CFTR-dependent Cl-/HCO3- exchange activities is responsible for cAMP-induced HCO3- secretion. More...
hsa01100	Metabolic pathways	237
hsa00561	Glycerolipid metabolism	15
hsa04975	Fat digestion and absorption	19	Fat is an important energy source from food. More than 95% o...... Fat is an important energy source from food. More than 95% of dietary fat is long-chain triacylglycerols (TAG), the remaining being phospholipids (4.5%) and sterols. In the small intestine lumen, dietary TAG is hydrolyzed to fatty acids (FA) and monoacylglycerols (MAG) by pancreatic lipase. These products are then emulsified with the help of phospholipids (PL) and bile acids (BA) present in bile to form micelles. Free FAs and MAGs are taken up by the enterocyte where they are rapidly resynthesized in endoplasmic reticulum (ER) to form TAG. PLs from the diet as well as bile - mainly LPA - too are absorbed by the enterocyte and are acylated to form phosphatidic acid (PA), which is also converted into TAG. Absorbed cholesterol (CL) is acylated to cholesterol esters (CE). Within the ER, TAG joins CE and apolipoprotein B (ApoB) to form chylomicrons that enter circulation through the lymph. More...

Genes shared at least 5 GO terms with PNLIPRP1 (count: 8)

Gene Symbol	Pathway Count	Pathway List
PNLIPRP2	7	carboxylesterase activity; triglyceride lipase activity; lipase activity; calcium ion binding; extracellular region; extracellular space; lipid metabolic process;
LPL	6	carboxylesterase activity; triglyceride lipase activity; lipase activity; extracellular region; extracellular space; lipid metabolic process;
APOC2	5	carboxylesterase activity; lipase activity; extracellular region; extracellular space; lipid metabolic process;
LIPG	5	carboxylesterase activity; triglyceride lipase activity; lipase activity; extracellular space; lipid metabolic process;
PLA2G1B	5	carboxylesterase activity; lipase activity; calcium ion binding; extracellular region; extracellular space;
PLA2G2A	5	carboxylesterase activity; lipase activity; calcium ion binding; extracellular region; extracellular space;
PLA2G3	5	carboxylesterase activity; lipase activity; calcium ion binding; extracellular region; extracellular space;
PNLIP	5	carboxylesterase activity; triglyceride lipase activity; lipase activity; extracellular region; lipid metabolic process;

Genes shared at least 2 KEGG pathways with PNLIPRP1 (count: 24)

Gene Symbol	Pathway Count	Pathway List
PNLIP	4	Pancreatic secretion; Metabolic pathways; Glycerolipid metabolism; Fat digestion and absorption;
PNLIPRP2	4	Pancreatic secretion; Metabolic pathways; Glycerolipid metabolism; Fat digestion and absorption;
PLA2G10	3	Pancreatic secretion; Metabolic pathways; Fat digestion and absorption;
PLA2G1B	3	Pancreatic secretion; Metabolic pathways; Fat digestion and absorption;
PLA2G2A	3	Pancreatic secretion; Metabolic pathways; Fat digestion and absorption;
PLA2G2D	3	Pancreatic secretion; Metabolic pathways; Fat digestion and absorption;
PLA2G2E	3	Pancreatic secretion; Metabolic pathways; Fat digestion and absorption;
PLA2G3	3	Pancreatic secretion; Metabolic pathways; Fat digestion and absorption;
PLA2G4B	3	Pancreatic secretion; Metabolic pathways; Fat digestion and absorption;
PLA2G5	3	Pancreatic secretion; Metabolic pathways; Fat digestion and absorption;
PLA2G6	3	Pancreatic secretion; Metabolic pathways; Fat digestion and absorption;
DGAT2	3	Metabolic pathways; Glycerolipid metabolism; Fat digestion and absorption;
LIPF	3	Metabolic pathways; Glycerolipid metabolism; Fat digestion and absorption;
PLCB2	2	Pancreatic secretion; Metabolic pathways;
PLCB3	2	Pancreatic secretion; Metabolic pathways;
ALDH3A2	2	Metabolic pathways; Glycerolipid metabolism;
DAK	2	Metabolic pathways; Glycerolipid metabolism;
DGKH	2	Metabolic pathways; Glycerolipid metabolism;
GPAT2	2	Metabolic pathways; Glycerolipid metabolism;
LIPG	2	Metabolic pathways; Glycerolipid metabolism;
MBOAT1	2	Metabolic pathways; Glycerolipid metabolism;
MBOAT2	2	Metabolic pathways; Glycerolipid metabolism;
MGLL	2	Metabolic pathways; Glycerolipid metabolism;
PNPLA3	2	Metabolic pathways; Glycerolipid metabolism;

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Region: chr10:118349897..118368687 View in gBrowse