ADHDgene Database

Gene Report

Basic Info

Approved Symbol	MPHOSPH6
Symbol Alias	MPP6
Approved Name	M-phase phosphoprotein 6
Location	16q23.3
Position	chr16:82181767-82203831, -
External Links	HGNC: 7214 Entrez Gene: 10200 Ensembl: ENSG00000135698 UCSC: uc002fgw.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16q23.1-24.3	chr16:74100000-90354753	1 (1/0/0)

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000460	maturation of 5.8S rRNA	Biological Process	IMP[17412707]	1
GO:0000178	exosome (RNase complex)	Cellular Component	IDA[11719186]	1
GO:0000176	nuclear exosome (RNase complex)	Cellular Component	TAS[11719186]	1
GO:0000087	M phase of mitotic cell cycle	Biological Process	TAS[8885239]	19
GO:0005737	cytoplasm	Cellular Component		690
GO:0005730	nucleolus	Cellular Component		243
GO:0005634	nucleus	Cellular Component		770
GO:0005515	protein binding	Molecular Function	IPI[17412707]	910
GO:0003723	RNA binding	Molecular Function		104

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03018	RNA degradation	8	The correct processing, quality control and turnover of cell...... The correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay exist and both pathways are initiated by poly(A) shortening of the mRNA. In the 5' to 3' pathway, this is followed by decapping which then permits the 5' to 3' exonucleolytic degradation of transcripts. In the 3' to 5' pathway, the exosome, a large multisubunit complex, plays a key role. The exosome exists in archaeal cells, too. In bacteria, endoribonuclease E, a key enzyme involved in RNA decay and processing, organizes a protein complex called degradosome. RNase E or R interacts with the phosphate-dependent exoribonuclease polynucleotide phosphorylase, DEAD-box helicases, and additional factors in the RNA-degrading complex. More...

Genes shared at least 5 GO terms with MPHOSPH6 (count: 13)

Gene Symbol	Pathway Count	Pathway List
PAFAH1B1	5	M phase of mitotic cell cycle; cytoplasm; nucleolus; nucleus; protein binding;
SMC1A	5	M phase of mitotic cell cycle; cytoplasm; nucleolus; nucleus; protein binding;
XPO1	5	M phase of mitotic cell cycle; cytoplasm; nucleolus; protein binding; RNA binding;
ALKBH8	5	cytoplasm; nucleolus; nucleus; protein binding; RNA binding;
ATXN2	5	cytoplasm; nucleolus; nucleus; protein binding; RNA binding;
FUS	5	cytoplasm; nucleolus; nucleus; protein binding; RNA binding;
HNRNPA2B1	5	cytoplasm; nucleolus; nucleus; protein binding; RNA binding;
HNRNPH1	5	cytoplasm; nucleolus; nucleus; protein binding; RNA binding;
NOL8	5	cytoplasm; nucleolus; nucleus; protein binding; RNA binding;
PDCD4	5	cytoplasm; nucleolus; nucleus; protein binding; RNA binding;
PSPC1	5	cytoplasm; nucleolus; nucleus; protein binding; RNA binding;
RBM4	5	cytoplasm; nucleolus; nucleus; protein binding; RNA binding;
ZFR	5	cytoplasm; nucleolus; nucleus; protein binding; RNA binding;

Genes shared at least 2 KEGG pathways with MPHOSPH6 (count: 0)

View in gBrowse

Region: chr16:82181767..82203831 View in gBrowse