ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	GNG3
Approved Name	guanine nucleotide binding protein (G protein), gamma 3
Name Alias	guanine nucleotide-binding protein gamma-3 subunit, "NBP gamma-3"
Location	11p11
Position	chr11:62475114-62476678, +
External Links	HGNC: 4405 Entrez Gene: 2785 Ensembl: ENSG00000162188 UCSC: uc001nuv.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0071377	cellular response to glucagon stimulus	Biological Process		5
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0007268	synaptic transmission	Biological Process		96
GO:0007186	G-protein coupled receptor signaling pathway	Biological Process		72
GO:0006184	GTP catabolic process	Biological Process	TAS[10075696]	22
GO:0006112	energy reserve metabolic process	Biological Process		25
GO:0005886	plasma membrane	Cellular Component		772
GO:0005834	heterotrimeric G-protein complex	Cellular Component		7
GO:0004871	signal transducer activity	Molecular Function		49
GO:0003924	GTPase activity	Molecular Function	TAS[10075696]	41
GO:0000187	activation of MAPK activity	Biological Process	TAS[10075696]	21

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04062	Chemokine signaling pathway	32	Inflammatory immune response requires the recruitment of leu...... Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival. More...
hsa04742	Taste transduction	7	All taste pathways are proposed to converge on common elemen...... All taste pathways are proposed to converge on common elements that mediate a rise in intracellular Ca2+ followed by neurotransmitter release. Na+ salt depolarizes taste cells by passive influx of Na+ through the amiloride-sensitive Na+ channel (ENaC). Acids depolarize taste cells by a variety of mechanisms, including influx of protons (H+) through ENaC and a proton-gated cation channel (MDEG). Two putative umami receptors have been identified: a truncated variant of the metabotropic glutamate receptor mGluR4 and the heterodimer, T1R1 + T1R3. Umami receptors are coupled to a signaling pathway involving activation of PLCbeta2, production of IP3 and diacylglycerol, release of Ca2+ from intracellular stores and activation of a transient receptor potential channel, TRPM5. Bitter compounds, such as denatonium and PROP, activate particular T2R/TRB isoforms, which activate gustducin heterotrimers. Activated alpha-gustducin stimulates PDE to hydrolyze cAMP, whereas betagamma subunits activate PLCbeta2 to generate IP3, which leads to release of Ca2+ from internal stores. Artificial sweeteners activate GPCRs (T1R heterodimers) apparently linked via PLC to IP3 production and release of Ca2+ from intracellular stores. Sugars apparently activate GPCRs linked via AC to cAMP production which, in turn, may inhibit basolateral K+ channels through phosphorylation by cAMP-activated protein kinase A (PKA). More...
hsa04724	Glutamatergic synapse	43	Glutamate is the major excitatory neurotransmitter in the ma...... Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synaptic cleft, glutamate acts on postsynaptic ionotropic glutamate receptors (iGluRs) to mediate fast excitatory synaptic transmission. Glutamate can also act on metabotropic glutamate receptors (mGluRs) and exert a variety of modulatory effects through their coupling to G proteins and the subsequent recruitment of second messenger systems. Presynaptically localized Group II and Group III mGluRs are thought to represent the classical inhibitory autoreceptor mechanism that suppresses excess glutamate release. After its action on these receptors, glutamate can be removed from the synaptic cleft by EAATs located either on the presynaptic terminal, neighboring glial cells, or the postsynaptic neuron. In glia, glutamate is converted to glutamine, which is then transported back to the presynaptic terminal and converted back to glutamate. More...

Genes shared at least 5 GO terms with GNG3 (count: 6)

Gene Symbol	Pathway Count	Pathway List
GNG10	10	cellular response to glucagon stimulus; small molecule metabolic process; synaptic transmission; G-protein coupled receptor signaling pathway; GTP catabolic process; energy reserve metabolic process; plasma membrane; heterotrimeric G-protein complex; signal transducer activity; GTPase activity;
GNAL	6	synaptic transmission; GTP catabolic process; plasma membrane; heterotrimeric G-protein complex; signal transducer activity; GTPase activity;
GNAT2	6	G-protein coupled receptor signaling pathway; GTP catabolic process; plasma membrane; heterotrimeric G-protein complex; signal transducer activity; GTPase activity;
GNAZ	6	G-protein coupled receptor signaling pathway; GTP catabolic process; plasma membrane; heterotrimeric G-protein complex; signal transducer activity; GTPase activity;
ADCY4	5	cellular response to glucagon stimulus; small molecule metabolic process; synaptic transmission; energy reserve metabolic process; plasma membrane;
GNAO1	5	GTP catabolic process; plasma membrane; heterotrimeric G-protein complex; signal transducer activity; GTPase activity;

Genes shared at least 2 KEGG pathways with GNG3 (count: 10)

Gene Symbol	Pathway Count	Pathway List
ADCY4	3	Chemokine signaling pathway; Taste transduction; Glutamatergic synapse;
PLCB2	3	Chemokine signaling pathway; Taste transduction; Glutamatergic synapse;
ADRBK1	2	Chemokine signaling pathway; Glutamatergic synapse;
ADRBK2	2	Chemokine signaling pathway; Glutamatergic synapse;
GNG10	2	Chemokine signaling pathway; Glutamatergic synapse;
MAPK1	2	Chemokine signaling pathway; Glutamatergic synapse;
MAPK3	2	Chemokine signaling pathway; Glutamatergic synapse;
PLCB3	2	Chemokine signaling pathway; Glutamatergic synapse;
PRKCB	2	Chemokine signaling pathway; Glutamatergic synapse;
CACNA1A	2	Taste transduction; Glutamatergic synapse;

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Region: chr11:62475114..62476678 View in gBrowse