ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	FGF9
Approved Name	fibroblast growth factor 9 (glia-activating factor)
Location	13q11-q12
Position	chr13:22245215-22278640, +
External Links	HGNC: 3687 Entrez Gene: 2254 Ensembl: ENSG00000102678 UCSC: uc001uog.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
13q12.11	chr13:19500000-23300000	1 (1/0/0)

Gene related GO terms (count: 34)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 34)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051781	positive regulation of cell division	Biological Process		11
GO:0060045	positive regulation of cardiac muscle cell proliferation	Biological Process		4
GO:0060484	lung-associated mesenchyme development	Biological Process		3
GO:0090263	positive regulation of canonical Wnt receptor signaling pathway	Biological Process		9
GO:0008584	male gonad development	Biological Process	IEP[17848411]	7
GO:0008543	fibroblast growth factor receptor signaling pathway	Biological Process	IGI[8663044]	26
GO:0008286	insulin receptor signaling pathway	Biological Process		32
GO:0008284	positive regulation of cell proliferation	Biological Process	IDA[8321227]	69
GO:0030326	embryonic limb morphogenesis	Biological Process		8
GO:0030238	male sex determination	Biological Process		2
GO:0030178	negative regulation of Wnt receptor signaling pathway	Biological Process		8
GO:0010628	positive regulation of gene expression	Biological Process		28
GO:0045880	positive regulation of smoothened signaling pathway	Biological Process		3
GO:0043410	positive regulation of MAPK cascade	Biological Process		17
GO:0042472	inner ear morphogenesis	Biological Process		6
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	Biological Process		6
GO:0050679	positive regulation of epithelial cell proliferation	Biological Process		9
GO:0048706	embryonic skeletal system development	Biological Process		4
GO:0048566	embryonic digestive tract development	Biological Process		2
GO:0048505	regulation of timing of cell differentiation	Biological Process		1
GO:0001525	angiogenesis	Biological Process		35
GO:0001649	osteoblast differentiation	Biological Process		9
GO:0005104	fibroblast growth factor receptor binding	Molecular Function		4
GO:0005576	extracellular region	Cellular Component		240
GO:0002053	positive regulation of mesenchymal cell proliferation	Biological Process		9
GO:0002062	chondrocyte differentiation	Biological Process		1
GO:0005737	cytoplasm	Cellular Component		690
GO:0006606	protein import into nucleus	Biological Process		5
GO:0005604	basement membrane	Cellular Component		14
GO:0005615	extracellular space	Cellular Component	IDA[8321227]	126
GO:0008083	growth factor activity	Molecular Function		25
GO:0008201	heparin binding	Molecular Function		26
GO:0007165	signal transduction	Biological Process	TAS[8575785]	171
GO:0007267	cell-cell signaling	Biological Process		38

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05218	Melanoma	12	Melanoma is a form of skin cancer that has a poor prognosis ...... Melanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes. The only known environmental risk factor is exposure to ultraviolet (UV) light and in people with fair skin the risk is greatly increased. Melanoma pathogenesis is also driven by genetic factors. Oncogenic NRAS mutations activate both effector pathways Raf-MEK-ERK and PI3K-Akt. The Raf-MEK-ERK pathway may also be activated via mutations in the BRAF gene. The PI3K-Akt pathway may be activated through loss or mutation of the inhibitory tumor suppressor gene PTEN. These mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression. Melanoma development has been shown to be strongly associated with inactivation of the p16INK4a/cyclin dependent kinases 4 and 6/retinoblastoma protein (p16INK4a/CDK4,6/pRb) and p14ARF/human double minute 2/p53 (p14ARF/HMD2/p53) tumor suppressor pathways. MITF and TP53 are implicated in further melanoma progression. More...
hsa04810	Regulation of actin cytoskeleton	48
hsa04010	MAPK signaling pathway	69	The mitogen-activated protein kinase (MAPK) cascade is a hig...... The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. More...
hsa05200	Pathways in cancer	52

Genes shared at least 5 GO terms with FGF9 (count: 23)

Gene Symbol	Pathway Count	Pathway List
VEGFA	12	positive regulation of cell division; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of epithelial cell proliferation; angiogenesis; extracellular region; positive regulation of mesenchymal cell proliferation; cytoplasm; extracellular space; growth factor activity; heparin binding;
FGF10	12	positive regulation of canonical Wnt receptor signaling pathway; fibroblast growth factor receptor signaling pathway; insulin receptor signaling pathway; positive regulation of MAPK cascade; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of epithelial cell proliferation; angiogenesis; fibroblast growth factor receptor binding; extracellular region; extracellular space; growth factor activity; heparin binding;
FGF4	10	positive regulation of cell division; fibroblast growth factor receptor signaling pathway; insulin receptor signaling pathway; positive regulation of cell proliferation; fibroblast growth factor receptor binding; extracellular region; growth factor activity; heparin binding; signal transduction; cell-cell signaling;
FGF3	8	positive regulation of cell division; fibroblast growth factor receptor signaling pathway; insulin receptor signaling pathway; positive regulation of cell proliferation; extracellular region; growth factor activity; signal transduction; cell-cell signaling;
CTGF	8	fibroblast growth factor receptor signaling pathway; positive regulation of cell proliferation; positive regulation of gene expression; angiogenesis; extracellular region; extracellular space; growth factor activity; heparin binding;
EREG	7	positive regulation of cell division; positive regulation of cell proliferation; angiogenesis; extracellular region; extracellular space; growth factor activity; cell-cell signaling;
IGF2	7	positive regulation of cell division; insulin receptor signaling pathway; positive regulation of cell proliferation; positive regulation of MAPK cascade; extracellular region; extracellular space; growth factor activity;
VEGFB	7	positive regulation of cell division; positive regulation of vascular endothelial growth factor receptor signaling pathway; angiogenesis; extracellular region; extracellular space; growth factor activity; heparin binding;
WNT11	6	lung-associated mesenchyme development; positive regulation of gene expression; embryonic skeletal system development; osteoblast differentiation; cytoplasm; extracellular space;
FGF19	6	fibroblast growth factor receptor signaling pathway; insulin receptor signaling pathway; positive regulation of cell proliferation; fibroblast growth factor receptor binding; extracellular region; growth factor activity;
INS	6	insulin receptor signaling pathway; positive regulation of cell proliferation; positive regulation of MAPK cascade; extracellular region; extracellular space; cell-cell signaling;
IL6	6	positive regulation of cell proliferation; positive regulation of MAPK cascade; positive regulation of epithelial cell proliferation; extracellular region; extracellular space; growth factor activity;
TBX1	6	positive regulation of cell proliferation; positive regulation of MAPK cascade; inner ear morphogenesis; positive regulation of epithelial cell proliferation; angiogenesis; positive regulation of mesenchymal cell proliferation;
TNC	6	positive regulation of cell proliferation; positive regulation of gene expression; extracellular region; basement membrane; extracellular space; signal transduction;
IL18	6	positive regulation of gene expression; angiogenesis; osteoblast differentiation; extracellular region; extracellular space; cell-cell signaling;
IHH	6	positive regulation of smoothened signaling pathway; osteoblast differentiation; extracellular region; positive regulation of mesenchymal cell proliferation; extracellular space; cell-cell signaling;
BTC	5	positive regulation of cell division; positive regulation of cell proliferation; extracellular region; extracellular space; growth factor activity;
INHA	5	male gonad development; extracellular region; growth factor activity; signal transduction; cell-cell signaling;
MAPK1	5	fibroblast growth factor receptor signaling pathway; insulin receptor signaling pathway; positive regulation of cell proliferation; cytoplasm; signal transduction;
CNTF	5	positive regulation of cell proliferation; cytoplasm; extracellular space; growth factor activity; signal transduction;
NTF3	5	positive regulation of cell proliferation; extracellular region; growth factor activity; signal transduction; cell-cell signaling;
COL15A1	5	angiogenesis; extracellular region; basement membrane; extracellular space; signal transduction;
FN1	5	angiogenesis; extracellular region; basement membrane; extracellular space; heparin binding;

Genes shared at least 2 KEGG pathways with FGF9 (count: 20)

Gene Symbol	Pathway Count	Pathway List
FGF10	4	Melanoma; Regulation of actin cytoskeleton; MAPK signaling pathway; Pathways in cancer;
FGF19	4	Melanoma; Regulation of actin cytoskeleton; MAPK signaling pathway; Pathways in cancer;
FGF3	4	Melanoma; Regulation of actin cytoskeleton; MAPK signaling pathway; Pathways in cancer;
FGF4	4	Melanoma; Regulation of actin cytoskeleton; MAPK signaling pathway; Pathways in cancer;
MAPK1	4	Melanoma; Regulation of actin cytoskeleton; MAPK signaling pathway; Pathways in cancer;
MAPK3	4	Melanoma; Regulation of actin cytoskeleton; MAPK signaling pathway; Pathways in cancer;
PIK3CG	3	Melanoma; Regulation of actin cytoskeleton; Pathways in cancer;
PIK3R1	3	Melanoma; Regulation of actin cytoskeleton; Pathways in cancer;
CRKL	3	Regulation of actin cytoskeleton; MAPK signaling pathway; Pathways in cancer;
BAD	2	Melanoma; Pathways in cancer;
CCND1	2	Melanoma; Pathways in cancer;
PDGFD	2	Melanoma; Regulation of actin cytoskeleton;
APC	2	Regulation of actin cytoskeleton; Pathways in cancer;
FN1	2	Regulation of actin cytoskeleton; Pathways in cancer;
ITGA2	2	Regulation of actin cytoskeleton; Pathways in cancer;
PAK1	2	Regulation of actin cytoskeleton; MAPK signaling pathway;
MAPK9	2	MAPK signaling pathway; Pathways in cancer;
PRKCB	2	MAPK signaling pathway; Pathways in cancer;
RELA	2	MAPK signaling pathway; Pathways in cancer;
TGFBR1	2	MAPK signaling pathway; Pathways in cancer;

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Region: chr13:22245215..22278640 View in gBrowse