Gene Report
Basic Info
Approved Symbol |
DNM1
|
Previous Symbol |
DNM |
Approved Name |
dynamin 1 |
Location |
9q34 |
Position |
chr9:130965658-131017527, + |
External Links |
HGNC: 2972
Entrez Gene: 1759
Ensembl: ENSG00000106976
UCSC: uc011mau.1
|
No. of Studies |
1 (significant: 0; non-significant: 0; trend: 1) |
Source |
Literature-origin; Mapped by LD-proxy; Mapped by literature SNP |
Gene related studies (count: 1)
Gene related SNPs (count: 7)
Gene related CNVs (count: 0)
Gene related other variant (count: 0)
Gene related regions (count: 0)
Gene related GO terms (count: 14)
Gene related KEGG pathways (count: 4)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa04144 |
Endocytosis |
39 |
Endocytosis is a mechanism for cells to remove ligands, nutr......
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
More...
|
hsa05100 |
Bacterial invasion of epithelial cells |
19 |
Many pathogenic bacteria can invade phagocytic and non-phago......
Many pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-phagocytic host cells (e.g. epithelial cells) using two mechanisms referred to as zipper model and trigger model. Listeria, Staphylococcus, Streptococcus, and Yersinia are examples of bacteria that enter using the zipper model. These bacteria express proteins on their surfaces that interact with cellular receptors, initiating signalling cascades that result in close apposition of the cellular membrane around the entering bacteria. Shigella and Salmonella are the examples of bacteria entering cells using the trigger model. These bacteria use type III secretion systems to inject protein effectors that interact with the actin cytoskeleton.
More...
|
hsa04666 |
Fc gamma R-mediated phagocytosis |
28 |
Phagocytosis plays an essential role in host-defense mechani......
Phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes take part in this process in higher organisms. After opsonization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes.
More...
|
hsa04961 |
Endocrine and other factor-regulated calcium reabsorption |
8 |
Calcium (Ca2+) is essential for numerous physiological funct......
Calcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis is finely maintained through the coordination of intestinal absorption, renal reabsorption, and bone resorption. In kidney, the late part of the distal convoluted tubule (DCT) and the connecting tubule (CNT) are the site of active Ca2+ transport and precisely regulate Ca2+ reabsorption. Following Ca2+ entry through TRPV5, Ca2+ bound to calbindin-D28K diffuses to the basolateral side, where it is extruded into the blood compartment through NCX1 and to a lesser extent PMCA1b. In the urinary compartment, both klotho and tissue kallikrein (TK) increase the apical abundance of TRPV5. In the blood compartment, PTH, 1,25(OH)2D3 and estrogen increase the transcription and protein expression of the luminal Ca2+ channels, calbindins, and the extrusion systems.
More...
|
Genes shared at least 5 GO terms with DNM1 (count: 0)
Genes shared at least 2 KEGG pathways with DNM1 (count: 15)
View in gBrowse