ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CDH15
Previous Symbol	CDH3, CDH14
Approved Name	cadherin 15, type 1, M-cadherin (myotubule)
Previous Name	cadherin 15, M-cadherin (myotubule)
Location	16q24.3
Position	chr16:89238163-89261900, +
External Links	HGNC: 1754 Entrez Gene: 1013 Ensembl: ENSG00000129910 UCSC: uc002fmt.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2012]_18	chr16:87694595-87778383 (NCBI36 / hg18)	83789	16q24.3	Del

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16q23.1-24.3	chr16:74100000-90354753	1 (1/0/0)

Gene related GO terms (count: 12)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051149	positive regulation of muscle cell differentiation	Biological Process		5
GO:0042692	muscle cell differentiation	Biological Process		8
GO:0045216	cell-cell junction organization	Biological Process		10
GO:0034329	cell junction assembly	Biological Process		13
GO:0034332	adherens junction organization	Biological Process		9
GO:0016021	integral to membrane	Cellular Component		845
GO:0031594	neuromuscular junction	Cellular Component		7
GO:0005901	caveola	Cellular Component		12
GO:0005886	plasma membrane	Cellular Component		772
GO:0007156	homophilic cell adhesion	Biological Process		27
GO:0007155	cell adhesion	Biological Process	TAS[9545347]	86
GO:0005509	calcium ion binding	Molecular Function		124

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04514	Cell adhesion molecules (CAMs)	20	Cell adhesion molecules are (glyco)proteins expressed on the...... Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes. More...

Genes shared at least 5 GO terms with CDH15 (count: 13)

Gene Symbol	Pathway Count	Pathway List
CDH2	10	positive regulation of muscle cell differentiation; muscle cell differentiation; cell-cell junction organization; cell junction assembly; adherens junction organization; integral to membrane; plasma membrane; homophilic cell adhesion; cell adhesion; calcium ion binding;
CDH6	8	cell-cell junction organization; cell junction assembly; adherens junction organization; integral to membrane; plasma membrane; homophilic cell adhesion; cell adhesion; calcium ion binding;
CDH12	7	cell-cell junction organization; cell junction assembly; adherens junction organization; integral to membrane; plasma membrane; homophilic cell adhesion; calcium ion binding;
CDH13	7	cell-cell junction organization; cell junction assembly; adherens junction organization; caveola; plasma membrane; homophilic cell adhesion; calcium ion binding;
CDH4	7	cell-cell junction organization; cell junction assembly; adherens junction organization; plasma membrane; homophilic cell adhesion; cell adhesion; calcium ion binding;
PVRL1	7	cell-cell junction organization; cell junction assembly; adherens junction organization; integral to membrane; plasma membrane; homophilic cell adhesion; cell adhesion;
CADM1	6	cell-cell junction organization; cell junction assembly; adherens junction organization; integral to membrane; plasma membrane; homophilic cell adhesion;
CDON	5	positive regulation of muscle cell differentiation; muscle cell differentiation; integral to membrane; plasma membrane; cell adhesion;
CTNND1	5	cell-cell junction organization; cell junction assembly; adherens junction organization; plasma membrane; cell adhesion;
CDHR5	5	integral to membrane; plasma membrane; homophilic cell adhesion; cell adhesion; calcium ion binding;
DSC2	5	integral to membrane; plasma membrane; homophilic cell adhesion; cell adhesion; calcium ion binding;
DSC3	5	integral to membrane; plasma membrane; homophilic cell adhesion; cell adhesion; calcium ion binding;
DSG2	5	integral to membrane; plasma membrane; homophilic cell adhesion; cell adhesion; calcium ion binding;

Genes shared at least 2 KEGG pathways with CDH15 (count: 0)

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Region: chr16:89238163..89261900 View in gBrowse