ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CD3G
Approved Name	CD3g molecule, gamma (CD3-TCR complex)
Previous Name	CD3g antigen, gamma polypeptide (TiT3 complex)
Location	11q23
Position	chr11:118215059-118225876, +
External Links	HGNC: 1675 Entrez Gene: 917 UCSC: uc001psu.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 17)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004888	transmembrane signaling receptor activity	Molecular Function	IMP[12794121]	20
GO:0005887	integral to plasma membrane	Cellular Component	NAS[9485181]	220
GO:0005886	plasma membrane	Cellular Component		772
GO:0007163	establishment or maintenance of cell polarity	Biological Process	IMP[12407027]	5
GO:0006461	protein complex assembly	Biological Process	NAS[12794121]	28
GO:0042981	regulation of apoptotic process	Biological Process	IMP[12407027]	32
GO:0046982	protein heterodimerization activity	Molecular Function	IPI[9485181]	68
GO:0050776	regulation of immune response	Biological Process		9
GO:0050852	T cell receptor signaling pathway	Biological Process		21
GO:0007166	cell surface receptor signaling pathway	Biological Process	IMP[12407027]	35
GO:0015031	protein transport	Biological Process	IMP[12794121]	75
GO:0030159	receptor signaling complex scaffold activity	Molecular Function	NAS[12794121]	8
GO:0031295	T cell costimulation	Biological Process		12
GO:0042101	T cell receptor complex	Cellular Component	NAS[9485181]	4
GO:0042105	alpha-beta T cell receptor complex	Cellular Component		3
GO:0042110	T cell activation	Biological Process	NAS[12407027]	8
GO:0042608	T cell receptor binding	Molecular Function	NAS[11186279]	2

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04640	Hematopoietic cell lineage	13	Blood-cell development progresses from a hematopoietic stem ...... Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing these differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes. More...
hsa04660	T cell receptor signaling pathway	19	Activation of T lymphocytes is a key event for an efficient ...... Activation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. Engagement of these receptors through the interaction with a foreign antigen associated with major histocompatibility complex molecules and CD28 counter-receptors B7.1/B7.2, respectively, results in a series of signaling cascades. These cascades comprise an array of protein-tyrosine kinases, phosphatases, GTP-binding proteins and adaptor proteins that regulate generic and specialised functions, leading to T-cell proliferation, cytokine production and differentiation into effector cells. More...
hsa05142	Chagas disease (American trypanosomiasis)	23	Trypanosoma cruzi is an intracellular protozoan parasite tha...... Trypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they invade diverse host cells including cardiomyocytes. Establishment of infection depends on various parasite molecules such as cruzipain, oligopeptidase B, and trans-sialidase that activate Ca2+ signaling. Internalized parasites escape from the parasitophorous vacuole using secreted pore-forming TcTOX molecule and replicate in the cytosol. Multiplied parasites eventually lyse infected host cells and are released in the circulation. During these events, the parasites manipulate host innate immunity and elicit cardiomyocyte hypertrophy. T lymphocyte responses are also disturbed. More...
hsa05162	Measles	20	Measles virus (MV) is highly contagious virus that leads inf...... Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacterial infections. Several MV proteins have been suggested to disturb host immunity. After infection of host lymphoid cells via SLAM, MV inhibits cytokine response by direct interference with host signaling systems. Three proteins (P, V, and C) associate with Jak/STAT proteins in interferon-triggered pathway and other important proteins related to apoptosis. Interaction between MV and host brings about the shift towards a Th2 response by decreasing IL-12 production and induces lymphopenia by suppressing cell proliferation. More...

Genes shared at least 5 GO terms with CD3G (count: 3)

Gene Symbol	Pathway Count	Pathway List
CD3E	15	transmembrane signaling receptor activity; integral to plasma membrane; plasma membrane; protein complex assembly; regulation of apoptotic process; protein heterodimerization activity; regulation of immune response; T cell receptor signaling pathway; cell surface receptor signaling pathway; receptor signaling complex scaffold activity; T cell costimulation; T cell receptor complex; alpha-beta T cell receptor complex; T cell activation; T cell receptor binding;
CD3D	9	transmembrane signaling receptor activity; plasma membrane; protein heterodimerization activity; regulation of immune response; T cell receptor signaling pathway; cell surface receptor signaling pathway; T cell costimulation; T cell receptor complex; alpha-beta T cell receptor complex;
SPN	6	transmembrane signaling receptor activity; integral to plasma membrane; plasma membrane; establishment or maintenance of cell polarity; cell surface receptor signaling pathway; T cell costimulation;

Genes shared at least 2 KEGG pathways with CD3G (count: 13)

Gene Symbol	Pathway Count	Pathway List
CD3D	4	Hematopoietic cell lineage; T cell receptor signaling pathway; Chagas disease (American trypanosomiasis); Measles;
CD3E	4	Hematopoietic cell lineage; T cell receptor signaling pathway; Chagas disease (American trypanosomiasis); Measles;
IL6	3	Hematopoietic cell lineage; Chagas disease (American trypanosomiasis); Measles;
PIK3CG	3	T cell receptor signaling pathway; Chagas disease (American trypanosomiasis); Measles;
PIK3R1	3	T cell receptor signaling pathway; Chagas disease (American trypanosomiasis); Measles;
RELA	3	T cell receptor signaling pathway; Chagas disease (American trypanosomiasis); Measles;
GSK3B	2	T cell receptor signaling pathway; Measles;
MAPK1	2	T cell receptor signaling pathway; Chagas disease (American trypanosomiasis);
MAPK3	2	T cell receptor signaling pathway; Chagas disease (American trypanosomiasis);
MAPK9	2	T cell receptor signaling pathway; Chagas disease (American trypanosomiasis);
IFNGR1	2	Chagas disease (American trypanosomiasis); Measles;
IL12B	2	Chagas disease (American trypanosomiasis); Measles;
TLR4	2	Chagas disease (American trypanosomiasis); Measles;

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Region: chr11:118215059..118225876 View in gBrowse