ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	C3AR1
Symbol Alias	C3AR, AZ3B
Approved Name	complement component 3a receptor 1
Location	12p13.31
Position	chr12:8210919-8218955, -
External Links	HGNC: 1319 Entrez Gene: 719 Ensembl: ENSG00000171860 UCSC: uc001qtv.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016298	lipase activity	Molecular Function		49

GO terms by database search (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004876	complement component C3a receptor activity	Molecular Function	TAS[8765043]	1
GO:0004930	G-protein coupled receptor activity	Molecular Function	IGI[10571060]	236
GO:0004435	phosphatidylinositol phospholipase C activity	Molecular Function	TAS[8765043]	20
GO:0045766	positive regulation of angiogenesis	Biological Process		12
GO:0010759	positive regulation of macrophage chemotaxis	Biological Process		2
GO:0010575	positive regulation vascular endothelial growth factor production	Biological Process		4
GO:0090023	positive regulation of neutrophil chemotaxis	Biological Process		5
GO:0006935	chemotaxis	Biological Process		15
GO:0005887	integral to plasma membrane	Cellular Component	TAS[8702752]	220
GO:0005886	plasma membrane	Cellular Component		772
GO:0004943	C3a anaphylatoxin receptor activity	Molecular Function		1
GO:0008015	blood circulation	Biological Process	TAS[8765043]	12
GO:0007204	elevation of cytosolic calcium ion concentration	Biological Process	IGI[10571060]	20
GO:0007186	G-protein coupled receptor signaling pathway	Biological Process	TAS[8898085]	72
GO:0006954	inflammatory response	Biological Process	TAS[8765043]	51

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93
hsa05150	Staphylococcus aureus infection	11	Staphylococcus aureus can cause multiple forms of infections...... Staphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the effectiveness of the immune system: secreting immune modulating proteins that inhibit complement activation and neutrophil chemotaxis or lysis, modulating the sensitivity to cationic antimicrobial peptides (such as defensin) by increasing the positive net charge of its cytoplasmic membrane, and expression of superantigens that prevent development of a normal immune response or cause an emetic response when ingested. More...
hsa04610	Complement and coagulation cascades	12	The complement system is a proteolytic cascade in blood plas...... The complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation: the classical pathway, the lectin pathway, and the alternative pathway. All of these pathways generate a crucial enzymatic activity that, in turn, generates the effector molecules of complement. The main consequences of complement activation are the opsonization of pathogens, the recruitment of inflammatory and immunocompetent cells, and the direct killing of pathogens. Blood coagulation is another series of proenzyme-to-serine protease conversions, culminating the formation of thrombin, the enzyme responsible for the conversion of soluble fibrinogen to the insoluble fibrin clot. Protease-activated receptors, such as those activated by thrombin, are members of G protein-coupled receptors and function as a mediator of innate immunity. The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium homeostasis, inflammatory processes, and the cardioprotective effects of preconditioning. More...

Genes shared at least 5 GO terms with C3AR1 (count: 12)

Gene Symbol	Pathway Count	Pathway List
BDKRB2	8	phosphatidylinositol phospholipase C activity; lipase activity; integral to plasma membrane; plasma membrane; blood circulation; elevation of cytosolic calcium ion concentration; G-protein coupled receptor signaling pathway; inflammatory response;
CCR5	8	phosphatidylinositol phospholipase C activity; lipase activity; chemotaxis; integral to plasma membrane; plasma membrane; elevation of cytosolic calcium ion concentration; G-protein coupled receptor signaling pathway; inflammatory response;
EDNRA	7	phosphatidylinositol phospholipase C activity; lipase activity; positive regulation of neutrophil chemotaxis; integral to plasma membrane; plasma membrane; elevation of cytosolic calcium ion concentration; G-protein coupled receptor signaling pathway;
CASR	6	G-protein coupled receptor activity; phosphatidylinositol phospholipase C activity; lipase activity; integral to plasma membrane; plasma membrane; G-protein coupled receptor signaling pathway;
S1PR3	6	G-protein coupled receptor activity; integral to plasma membrane; plasma membrane; elevation of cytosolic calcium ion concentration; G-protein coupled receptor signaling pathway; inflammatory response;
CXCR1	5	G-protein coupled receptor activity; chemotaxis; plasma membrane; G-protein coupled receptor signaling pathway; inflammatory response;
LPAR1	5	G-protein coupled receptor activity; integral to plasma membrane; plasma membrane; elevation of cytosolic calcium ion concentration; G-protein coupled receptor signaling pathway;
CCKBR	5	phosphatidylinositol phospholipase C activity; lipase activity; integral to plasma membrane; plasma membrane; elevation of cytosolic calcium ion concentration;
CHRM1	5	phosphatidylinositol phospholipase C activity; lipase activity; integral to plasma membrane; plasma membrane; G-protein coupled receptor signaling pathway;
CHRM3	5	phosphatidylinositol phospholipase C activity; lipase activity; integral to plasma membrane; plasma membrane; G-protein coupled receptor signaling pathway;
C5	5	positive regulation of angiogenesis; positive regulation vascular endothelial growth factor production; chemotaxis; G-protein coupled receptor signaling pathway; inflammatory response;
CXCR2	5	chemotaxis; integral to plasma membrane; plasma membrane; elevation of cytosolic calcium ion concentration; inflammatory response;

Genes shared at least 2 KEGG pathways with C3AR1 (count: 3)

Gene Symbol	Pathway Count	Pathway List
BDKRB2	2	Neuroactive ligand-receptor interaction; Complement and coagulation cascades;
C5	2	Staphylococcus aureus infection; Complement and coagulation cascades;
MASP2	2	Staphylococcus aureus infection; Complement and coagulation cascades;

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Region: chr12:8210919..8218955 View in gBrowse