ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ADAM17
Previous Symbol	TACE
Symbol Alias	cSVP, CD156B
Approved Name	ADAM metallopeptidase domain 17
Previous Name	tumor necrosis factor, alpha, converting enzyme
Location	2p25
Position	chr2:9628615-9695921, -
External Links	HGNC: 195 Entrez Gene: 6868 Ensembl: ENSG00000151694 UCSC: uc002qzu.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
2p25.1	chr2:7100000-12200000	2 (1/0/1)

Gene related GO terms (count: 52)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 52)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0033077	T cell differentiation in thymus	Biological Process	ISS[10433800]	3
GO:0033627	cell adhesion mediated by integrin	Biological Process	IDA[14970227]	1
GO:0035313	wound healing, spreading of epidermal cells	Biological Process	IEP[14970227]	2
GO:0035625	epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	Biological Process	IMP[17655843]	4
GO:0032587	ruffle membrane	Cellular Component	IDA[14970227]	12
GO:0032717	negative regulation of interleukin-8 production	Biological Process	IMP[16034137]	2
GO:0032722	positive regulation of chemokine production	Biological Process	IMP[16034137]	5
GO:0033025	regulation of mast cell apoptotic process	Biological Process	ISS[10433800]	1
GO:0048536	spleen development	Biological Process	ISS[10433800]	5
GO:0048870	cell motility	Biological Process	ISS[10433800]	3
GO:0051088	PMA-inducible membrane protein ectodomain proteolysis	Biological Process	IDA[14625290]; IMP[18676862]	1
GO:0051272	positive regulation of cellular component movement	Biological Process	ISS[10433800]	5
GO:0042493	response to drug	Biological Process	ISS[10433800]	68
GO:0045121	membrane raft	Cellular Component	IDA[17010968]	22
GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	Biological Process	IDA[18483258]; IMP[17655843]	3
GO:0048011	nerve growth factor receptor signaling pathway	Biological Process		42
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway	Biological Process		5
GO:0055099	response to high density lipoprotein particle stimulus	Biological Process	IDA[17786981]	1
GO:0001666	response to hypoxia	Biological Process	IDA[18276953]	34
GO:0001934	positive regulation of protein phosphorylation	Biological Process	IMP[18625725]	22
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	Biological Process	ISS[10433800]	6
GO:0031293	membrane protein intracellular domain proteolysis	Biological Process		2
GO:0031659	positive regulation of cyclin-dependent protein kinase activity involved in G1/S	Biological Process	IDA[18483258]	2
GO:0032496	response to lipopolysaccharide	Biological Process	IDA[18383040]	22
GO:0030165	PDZ domain binding	Molecular Function	IPI[12207026]	13
GO:0030183	B cell differentiation	Biological Process	ISS[10433800]	8
GO:0030307	positive regulation of cell growth	Biological Process	IMP[18373975]	8
GO:0030335	positive regulation of cell migration	Biological Process	IMP[18373975]	29
GO:0010820	positive regulation of T cell chemotaxis	Biological Process	IMP[18373975]	1
GO:0015629	actin cytoskeleton	Cellular Component	IDA[17010968]	26
GO:0016324	apical plasma membrane	Cellular Component	IDA[16034137]	51
GO:0017124	SH3 domain binding	Molecular Function		22
GO:0008237	metallopeptidase activity	Molecular Function	IDA[12777399]; IMP[12535668]	13
GO:0008270	zinc ion binding	Molecular Function		323
GO:0008284	positive regulation of cell proliferation	Biological Process	IMP[18373975]	69
GO:0009986	cell surface	Cellular Component	IDA[18625725]	70
GO:0007155	cell adhesion	Biological Process	IDA[14970227]	86
GO:0006509	membrane protein ectodomain proteolysis	Biological Process	IDA[18676862]; IMP[18373975]	3
GO:0007219	Notch signaling pathway	Biological Process		21
GO:0007173	epidermal growth factor receptor signaling pathway	Biological Process	IDA[12743035]	25
GO:0005887	integral to plasma membrane	Cellular Component	IDA[17786981]	220
GO:0005886	plasma membrane	Cellular Component		772
GO:0005925	focal adhesion	Cellular Component	IDA[14970227]	26
GO:0005911	cell-cell junction	Cellular Component	IDA[14970227]	20
GO:0005178	integrin binding	Molecular Function	IPI[14970227]	15
GO:0005138	interleukin-6 receptor binding	Molecular Function	IPI[16034137]	3
GO:0005737	cytoplasm	Cellular Component		690
GO:0005515	protein binding	Molecular Function	IPI[10527948]	910
GO:0002467	germinal center formation	Biological Process	ISS[10433800]	1
GO:0002446	neutrophil mediated immunity	Biological Process	IC[16034137]	3
GO:0004222	metalloendopeptidase activity	Molecular Function	IDA[9920899]; IMP[9034191]	33
GO:0002690	positive regulation of leukocyte chemotaxis	Biological Process	IC[16034137]	3

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05120	Epithelial cell signaling in Helicobacter pylori infection	16	Two major virulence factors of H. pylori are the vacuolating...... Two major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA). More...
hsa04330	Notch signaling pathway	8	The Notch signaling pathway is an evolutionarily conserved, ...... The Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch proteins (Notch1-Notch4 in vertebrates) are single-pass receptors that are activated by the Delta (or Delta-like) and Jagged/Serrate families of membrane-bound ligands. They are transported to the plasma membrane as cleaved, but otherwise intact polypeptides. Interaction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD translocates to the nucleus, where it forms a complex with the DNA binding protein CSL, displacing a histone deacetylase (HDAc)-co-repressor (CoR) complex from CSL. Components of an activation complex, such as MAML1 and histone acetyltransferases (HATs), are recruited to the NICD-CSL complex, leading to the transcriptional activation of Notch target genes. More...
hsa05010	Alzheimer's disease	40	Alzheimer's disease (AD) is a chronic disorder that slowly d...... Alzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. The extracellular Abeta oligomers may activate caspases through activation of cell surface death receptors. Alternatively, intracellular Abeta may contribute to pathology by facilitating tau hyper-phosphorylation, disrupting mitochondria function, and triggering calcium dysfunction. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress. More...

Genes shared at least 5 GO terms with ADAM17 (count: 70)

Gene Symbol	Pathway Count	Pathway List
BCAR1	9	nerve growth factor receptor signaling pathway; positive regulation of cell migration; SH3 domain binding; cell adhesion; epidermal growth factor receptor signaling pathway; plasma membrane; focal adhesion; cytoplasm; protein binding;
ILK	9	positive regulation of cell migration; SH3 domain binding; positive regulation of cell proliferation; plasma membrane; focal adhesion; cell-cell junction; integrin binding; cytoplasm; protein binding;
ADRA2A	8	epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway; positive regulation of epidermal growth factor-activated receptor activity; positive regulation of cell migration; positive regulation of cell proliferation; integral to plasma membrane; plasma membrane; cytoplasm; protein binding;
VEGFA	8	positive regulation of cellular component movement; response to hypoxia; positive regulation of protein phosphorylation; positive regulation of cell migration; positive regulation of cell proliferation; cell surface; cytoplasm; protein binding;
GSK3B	8	response to drug; membrane raft; nerve growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; plasma membrane; integrin binding; cytoplasm; protein binding;
MAPK1	8	nerve growth factor receptor signaling pathway; JAK-STAT cascade involved in growth hormone signaling pathway; positive regulation of cell migration; positive regulation of cell proliferation; epidermal growth factor receptor signaling pathway; focal adhesion; cytoplasm; protein binding;
ADAM8	8	metallopeptidase activity; zinc ion binding; cell surface; integral to plasma membrane; plasma membrane; cytoplasm; protein binding; metalloendopeptidase activity;
APC	7	T cell differentiation in thymus; ruffle membrane; positive regulation of cell migration; cell adhesion; plasma membrane; cytoplasm; protein binding;
IL6	7	positive regulation of chemokine production; response to drug; response to lipopolysaccharide; positive regulation of cell proliferation; interleukin-6 receptor binding; neutrophil mediated immunity; positive regulation of leukocyte chemotaxis;
SNCA	7	response to drug; response to lipopolysaccharide; actin cytoskeleton; zinc ion binding; plasma membrane; cytoplasm; protein binding;
FZD4	7	PDZ domain binding; cell surface; integral to plasma membrane; plasma membrane; cell-cell junction; cytoplasm; protein binding;
PTPRJ	6	ruffle membrane; cell surface; integral to plasma membrane; plasma membrane; cell-cell junction; protein binding;
TLR4	6	positive regulation of chemokine production; response to lipopolysaccharide; integral to plasma membrane; plasma membrane; cytoplasm; protein binding;
ETS1	6	cell motility; positive regulation of cellular component movement; response to hypoxia; positive regulation of cell migration; positive regulation of cell proliferation; protein binding;
TGFBR1	6	cell motility; positive regulation of cellular component movement; positive regulation of cell growth; positive regulation of cell proliferation; plasma membrane; protein binding;
GRIN2A	6	response to drug; zinc ion binding; cell surface; integral to plasma membrane; plasma membrane; protein binding;
INPPL1	6	response to drug; SH3 domain binding; cell adhesion; plasma membrane; cytoplasm; protein binding;
RELA	6	response to drug; nerve growth factor receptor signaling pathway; membrane protein intracellular domain proteolysis; positive regulation of cell proliferation; cytoplasm; protein binding;
SLC6A4	6	response to drug; membrane raft; response to hypoxia; integral to plasma membrane; plasma membrane; protein binding;
GJA1	6	membrane raft; PDZ domain binding; SH3 domain binding; integral to plasma membrane; plasma membrane; protein binding;
THY1	6	membrane raft; apical plasma membrane; integral to plasma membrane; plasma membrane; integrin binding; protein binding;
MAPK3	6	nerve growth factor receptor signaling pathway; JAK-STAT cascade involved in growth hormone signaling pathway; positive regulation of protein phosphorylation; epidermal growth factor receptor signaling pathway; focal adhesion; protein binding;
PIK3R1	6	nerve growth factor receptor signaling pathway; B cell differentiation; positive regulation of cell migration; epidermal growth factor receptor signaling pathway; plasma membrane; protein binding;
EDNRA	6	response to hypoxia; positive regulation of protein phosphorylation; response to lipopolysaccharide; positive regulation of cell proliferation; integral to plasma membrane; plasma membrane;
PAK1	6	response to hypoxia; plasma membrane; focal adhesion; cell-cell junction; cytoplasm; protein binding;
DAB2	6	positive regulation of protein phosphorylation; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of cell migration; apical plasma membrane; integrin binding; protein binding;
ERBB2	6	positive regulation of protein phosphorylation; positive regulation of cell growth; apical plasma membrane; epidermal growth factor receptor signaling pathway; plasma membrane; protein binding;
FLT4	6	positive regulation of protein phosphorylation; positive regulation of cell proliferation; integral to plasma membrane; plasma membrane; cytoplasm; protein binding;
SEMA4D	6	positive regulation of protein phosphorylation; positive regulation of cell migration; cell adhesion; integral to plasma membrane; plasma membrane; protein binding;
TGFB1I1	6	positive regulation of transforming growth factor beta receptor signaling pathway; zinc ion binding; cell adhesion; focal adhesion; cytoplasm; protein binding;
CBL	6	SH3 domain binding; zinc ion binding; epidermal growth factor receptor signaling pathway; plasma membrane; cytoplasm; protein binding;
LPXN	6	zinc ion binding; cell adhesion; plasma membrane; focal adhesion; cytoplasm; protein binding;
ADRA2C	5	epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane; cytoplasm; protein binding;
ARRB1	5	negative regulation of interleukin-8 production; Notch signaling pathway; plasma membrane; cytoplasm; protein binding;
FGF10	5	spleen development; positive regulation of cyclin-dependent protein kinase activity involved in G1/S; response to lipopolysaccharide; cell surface; plasma membrane;
ADORA2A	5	response to drug; nerve growth factor receptor signaling pathway; integral to plasma membrane; plasma membrane; protein binding;
CYBA	5	response to drug; positive regulation of cell growth; apical plasma membrane; SH3 domain binding; protein binding;
DRD1	5	response to drug; positive regulation of cell migration; integral to plasma membrane; plasma membrane; protein binding;
DRD2	5	response to drug; response to hypoxia; integral to plasma membrane; plasma membrane; protein binding;
DRD3	5	response to drug; positive regulation of cell proliferation; integral to plasma membrane; plasma membrane; protein binding;
SLC6A3	5	response to drug; integral to plasma membrane; plasma membrane; cytoplasm; protein binding;
TJP1	5	response to drug; response to lipopolysaccharide; plasma membrane; cytoplasm; protein binding;
CAV3	5	membrane raft; positive regulation of cell proliferation; cell surface; plasma membrane; protein binding;
FURIN	5	membrane raft; nerve growth factor receptor signaling pathway; cell surface; Notch signaling pathway; plasma membrane;
PRKAR2B	5	membrane raft; nerve growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; plasma membrane; cytoplasm;
EREG	5	positive regulation of epidermal growth factor-activated receptor activity; positive regulation of cell proliferation; epidermal growth factor receptor signaling pathway; integral to plasma membrane; protein binding;
AATF	5	nerve growth factor receptor signaling pathway; cell adhesion; focal adhesion; cytoplasm; protein binding;
ADCY4	5	nerve growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; plasma membrane; cytoplasm; protein binding;
ADRBK1	5	nerve growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; plasma membrane; cytoplasm; protein binding;
UBB	5	nerve growth factor receptor signaling pathway; Notch signaling pathway; epidermal growth factor receptor signaling pathway; plasma membrane; protein binding;
UBC	5	nerve growth factor receptor signaling pathway; Notch signaling pathway; epidermal growth factor receptor signaling pathway; plasma membrane; protein binding;
GHR	5	JAK-STAT cascade involved in growth hormone signaling pathway; cell surface; integral to plasma membrane; plasma membrane; protein binding;
CRYAB	5	response to hypoxia; cell surface; plasma membrane; cytoplasm; protein binding;
FLCN	5	positive regulation of protein phosphorylation; positive regulation of transforming growth factor beta receptor signaling pathway; plasma membrane; cytoplasm; protein binding;
ADRB1	5	PDZ domain binding; integral to plasma membrane; plasma membrane; cytoplasm; protein binding;
LPAR1	5	PDZ domain binding; cell surface; integral to plasma membrane; plasma membrane; protein binding;
TRIM32	5	positive regulation of cell growth; positive regulation of cell migration; zinc ion binding; cytoplasm; protein binding;
ARPC2	5	actin cytoskeleton; plasma membrane; focal adhesion; cytoplasm; protein binding;
BAIAP2	5	actin cytoskeleton; SH3 domain binding; plasma membrane; cytoplasm; protein binding;
LIMA1	5	actin cytoskeleton; zinc ion binding; plasma membrane; focal adhesion; cytoplasm;
ASTL	5	zinc ion binding; cell adhesion; plasma membrane; cytoplasm; metalloendopeptidase activity;
GRIN2B	5	zinc ion binding; cell surface; integral to plasma membrane; plasma membrane; protein binding;
MMP16	5	zinc ion binding; cell surface; integral to plasma membrane; plasma membrane; metalloendopeptidase activity;
HES1	5	positive regulation of cell proliferation; cell adhesion; Notch signaling pathway; cytoplasm; protein binding;
CCR5	5	cell surface; integral to plasma membrane; plasma membrane; cytoplasm; protein binding;
NRXN1	5	cell surface; cell adhesion; integral to plasma membrane; plasma membrane; protein binding;
PTPRK	5	cell surface; cell adhesion; integral to plasma membrane; cell-cell junction; protein binding;
SCARB1	5	cell surface; cell adhesion; integral to plasma membrane; plasma membrane; cytoplasm;
CTNND1	5	cell adhesion; plasma membrane; cell-cell junction; cytoplasm; protein binding;
PRKD1	5	integral to plasma membrane; plasma membrane; cell-cell junction; cytoplasm; protein binding;

Genes shared at least 2 KEGG pathways with ADAM17 (count: 0)

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Region: chr2:9628615..9695921 View in gBrowse