|Gene: TRD Link to MethyView|
|Alias||TCR-delta, TRD@, TCD@, TCRD|
|Description||Breakpoint on der(7) lie 5' from Jd1. Breakpoint on der(14)lies 12 nucleotides 5' of the 3' end of the DREC segment.Protein encoded by the TCRD locus are the T-cell receptor chains.|
|Description||the TCR delta variable (V) diversity (D) joining (J) and constant region genes are situated within the TCR alpha locus between the TCR alpha V and the TCR alpha J segments. The TCR alpha/delta locus is transcribed in a centromer to telomer direction.T-cell receptor T-cell acute lymphocytic leukemia (ALL)|
|Description||T- cell acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL)|
|Description||or TRB in the case of a 7q34-36 involvementT-cell receptor T-cell Acute lymphocytic leukemia (ALL)|
|Description||" The size of TCR alpha/delta locus is about 1 Mb. The TCR delta variable (V) diversity (D) joining (J) and constant region genes are situated within the TCR alpha locus between the TCR alpha V and the TCR alpha J segments. The TCR delta locus contains three D segments and four J segments, whereas the TCR alpha J regions spans approximately 80 Kb and contains at least 61 segments. The TCR alpha/delta locus is transcribed in a centromer to telomer direction.T-cell receptor "|
|Cancer Name||T-cell large granular lymphocyte leukaemia|
|Description||" As with other T-cell lymphoproliferative disorders, T-LGL exhibits clonal rearrangement of the TCR genes; in most cases, the TCRA TCRD genes are rearranged, but rarely, the TCRG gene is rearranged while the TCRB gene is in germline configuration.
Unlike other T-cell malignancies, karyotypic aberrations in T-LGL rarely involve the TCR gene loci; so far, only one case each with possible involvement of the TCRG gene at 7p14-p15 in an inv(7)(p15q22) and the TCR A/D genes at 14q11 in an inv(14)(q11q32) has been described. "
|Description||T-cell receptor delta|
|DNA methylation and CGIs|
|Gene MethyCancer Type||Annotated cancer gene without methylation data|
|Link to MethyView|