Gene Report

Gene: TRD     Link to MethyView
Summary
Gene symbol TRD
Alias TCR-delta, TRD@, TCD@, TCRD
Cytogenetic Location 14q11.2
Description "
  • The human TRD locus at 14q11.2 comprises a cluster of one TRDV gene (TRDV2), three TRDD segments, and four TRDJ segments, upstream of the unique TRDC gene; another TRDV gene (TRDV3) is localized downstream of the TRDC gene, in inverted orientation of transcription.
  • This cluster spans 60 kb and is localized inside the TRA locus, between the TRAV genes and the TRAJ segments. One TRDV gene (TRDV1) is localized at 360 kb upstream of the TRDC gene, among the TRAV genes. Five variable genes have been found rearranged to both (D)J segments of the TRD locus and TRAJ segments, and can therefore be used for the synthesis of both delta and alpha chains. These genes are described as TRAV/DV.
  • The TRDV genes are unique members of different subgroups. All the TRD genes are functional, with the exception of one TRAV/DV, which has been found either functional or as a pseudogene.
  • Enhancer sequences have been described between the TRDJ3 and the TRDC gene.
  • List of the human TRD genes"
  • External Links
     
    Diseases(Cancers)
    Cancer Name t(7;14)(p15;q11)
    Description Breakpoint on der(7) lie 5' from Jd1. Breakpoint on der(14)lies 12 nucleotides 5' of the 3' end of the DREC segment.Protein encoded by the TCRD locus are the T-cell receptor chains.
     
    Cancer Name t(8;14)(q24;q11)
    Description the TCR delta variable (V) diversity (D) joining (J) and constant region genes are situated within the TCR alpha locus between the TCR alpha V and the TCR alpha J segments. The TCR alpha/delta locus is transcribed in a centromer to telomer direction.T-cell receptor T-cell acute lymphocytic leukemia (ALL)
     
    Cancer Name t(1;7)(p32;q34)
    Description T- cell acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL)
     
    Cancer Name t(10;14)(q24;q11)
    Description or TRB in the case of a 7q34-36 involvementT-cell receptor T-cell Acute lymphocytic leukemia (ALL)
     
    Cancer Name t(11;14)(p15;q11)
    Description " The size of TCR alpha/delta locus is about 1 Mb. The TCR delta variable (V) diversity (D) joining (J) and constant region genes are situated within the TCR alpha locus between the TCR alpha V and the TCR alpha J segments. The TCR delta locus contains three D segments and four J segments, whereas the TCR alpha J regions spans approximately 80 Kb and contains at least 61 segments. The TCR alpha/delta locus is transcribed in a centromer to telomer direction.T-cell receptor "
     
    Cancer Name inv(14)(q11q32.1)
    Description "
  • The size of TCR alpha/delta locus is about 1 Mb. The TCR delta variable (V) diversity (D) joining (J) and constant region genes are situated within the TCR alpha locus between the TCR alpha V and the TCR alpha J segments.
  • The TCR delta locus contains three D segments and four J segments, whereas the TCR alpha J regions spans approximately 80 Kb and contains at least 61 segments.
  • The TCR alpha/delta locus is transcribed in a centromer to telomer direction.T-cell receptor "
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    Cancer Name T-cell large granular lymphocyte leukaemia
    Description " As with other T-cell lymphoproliferative disorders, T-LGL exhibits clonal rearrangement of the TCR genes; in most cases, the TCRA TCRD genes are rearranged, but rarely, the TCRG gene is rearranged while the TCRB gene is in germline configuration.
    Unlike other T-cell malignancies, karyotypic aberrations in T-LGL rarely involve the TCR gene loci; so far, only one case each with possible involvement of the TCRG gene at 7p14-p15 in an inv(7)(p15q22) and the TCR A/D genes at 14q11 in an inv(14)(q11q32) has been described. "
     
    Cancer Name t(11;14)(p13;q11)
     
    Cancer Name t(7;12)(q34;p13)
    Description T-cell receptor delta
     
     
    DNA methylation and CGIs
    Gene MethyCancer Type Annotated cancer gene without methylation data
    Link to MethyView