Gene Report

Gene: TCL1A     Link to MethyView
Summary
Gene symbol TCL1A
Alias TCL1, TCL1A
Cytogenetic Location 14q32.1
Type KNOWN
Property protein_coding
Description T-cell leukemia/lymphoma protein 1A (P14 TCL1 protein) (TCL1 oncogene) (TCL-1 protein) [TCL1]
External Links
   Ensembl ENSG00000100721
   OMIM 186960
   mRNA NM_021966.1
   SwissProt P56279
 
Diseases(Cancers)
Cancer Name Chronic lymphocytic leukaemia (CLL)
Description From cancer gene census of CGP:
 
Cancer Name inv(14)(q11q32.1)
Description "TRA@ - TCL1 in T-cell malignancies. mainly http://atlasgeneticsoncology.org/Anomalies/TPLL.html, T-cell prolymphocytic leukemia (T-PLL); T- cell NHL; T-cell ALL "
Oncogenesis over expression of TCL1 is considered as critical in the oncogenetic mechanism
 
 
Genomic Regions, Transcripts and Proteins
Gene Structure <0...913>, <1781...1834>, <2252...2428>, <3979...4143>
Ensembl Transcript ENST00000216612
Ensembl Protein ENSP00000216612
Gene Ontology GO:0005783 IEA Generated via Q969Q5
GO:0005792 IEA Generated via P06133
GO:0045120 IEA from Mus musculus translation ENSMUSP00000080419
GO:0005938 IEA Generated via O60759
GO:0005515 IPI Generated via P54259
GO:0007275 TAS Generated via Q99217
 
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DNA methylation and CGIs
Gene MethyCancer Type Annotated cancer gene with CGI prediction
Link to MethyView
 
Bibliography
Title Characterization and localization of the TCL-1 oncogene product.
Authors Fu TB, Virgilio L, Narducci MG, Facchiano A, Russo G, Croce CM
Citations Cancer Res 1994 Dec 15;54(24):6297-301
PubMedID 95079394
 
Title Chromosome walking on the TCL1 locus involved in T-cell neoplasia.
Authors Virgilio L, Isobe M, Narducci MG, Carotenuto P, Camerini B, Kurosawa N, Abbas-ar-Rushdi, Croce CM, Russo G
Citations Proc Natl Acad Sci U S A 1993 Oct 15;90(20):9275-9
PubMedID 94022358
 
Title TCL1 oncogene activation in preleukemic T cells from a case of ataxia-telangiectasia.
Authors Narducci MG, Virgilio L, Isobe M, Stoppacciaro A, Elli R, Fiorilli M, Carbonari M, Antonelli A, Chessa L, Croce CM, et al
Citations Blood 1995 Sep 15;86(6):2358-64
PubMedID 95391995
 
Title Identification of the TCL1 gene involved in T-cell malignancies
Authors Virgilio L, Narducci MG, Isobe M, Billips LG, Cooper MD, Croce CM, Russo G
Citations Proc Natl Acad Sci U S A 1994 Dec 20;91(26):12530-4
PubMedID 95107991
 
Title TCL1 is overexpressed in patients affected by adult T-cell leukemias.
Authors Narducci MG, Stoppacciaro A, Imada K, Uchiyama T, Virgilio L, Lazzeri C, Croce CM, Russo G
Citations Cancer Res 1997 Dec 15;57(24):5452-6
PubMedID 98069837
 
Title Expression of either the TCL1 oncogene, or transcripts from its homologue MTCP1/c6.1B, in leukaemic and non-leukaemic T cells from ataxia telangiectasia patients.
Authors Thick J, Metcalfe JA, Mak YF, Beatty D, Minegishi M, Dyer MJ, Lucas G, Taylor AM
Citations Oncogene 1996 Jan 18;12(2):379-86
PubMedID 96152904
 
Title Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology.
Authors Hoh F, Yang YS, Guignard L, Padilla A, Stern MH, Lhoste JM, van Tilbeurgh H
Citations Structure 1998 Feb 15;6(2):147-55
PubMedID 98179932
 
Title The murine Tcl1 oncogene: embryonic and lymphoid cell expression.
Authors Narducci MG, Virgilio L, Engiles JB, Buchberg AM, Billips L, Facchiano A, Croce CM, Russo G, Rothstein JL
Citations Oncogene 1997 Aug 18;15(8):919-26
PubMedID 97430049