Cancer Report

Cancer : Esophageal tumors
Summary
Cancer Name Esophageal tumors
Cancer Alias "Oesophagus cancer, Oesophagus tumors"
Description Cancer that forms in tissues lining the esophagus (the muscular tube through which food passes from the throat to the stomach). Two types of esophageal cancer are squamous cell carcinoma (cancer that begins in flat cells lining the esophagus) and adenocarcinoma (cancer that begins in cells that make and release mucus and other fluids).
 
Clinics and Pathology
 
Related Genes
Gene Symbol EGFR
Description Fomr COSMIC:
 
Gene Symbol SHH
Description From OMIM: "Berman et al. (2003) demonstrated that a wide range of digestive tract tumors, including most of those originating in the esophagus, stomach, biliary tract, and pancreas, but not in the colon, display increased hedgehog pathway activity, which is suppressible by cyclopamine, a hedgehog pathway antagonist. Cyclopamine also suppresses cell growth in vitro and causes durable regression of xenograft tumor in vivo. Unlike tumors in Gorlin syndrome (109400), pathway activity and cell growth in these digestive tract tumors are driven by endogenous expression of hedgehog ligands, as indicated by the presence of Sonic hedgehog and Indian hedgehog transcripts, by the pathway- and growth-inhibitory activity of a hedgehog-neutralizing antibody, and by the dramatic growth-stimulatory activity of exogenously added hedgehog ligand. Berman et al. (2003) concluded that their results identified a group of common lethal malignancies in which hedgehog pathway activity, essential for tumor growth, is activated not by mutation but by ligand expression."
 
Gene Symbol FHIT
Description From OMIM: "Ohta et al. (1996) identified a human gene, which they designated fragile histidine triad (FHIT). The FHIT gene, a member of the histidine triad gene family, encodes a protein similar to the aph1 gene in S. pombe. The gene is composed of 10 exons distributed over at least 500 kb, with three 5-prime untranslated exons centromeric to the renal carcinoma-associated 3p14.2 breakpoint, the remaining exons telomeric to this translocation breakpoint, and exon 5 within the homozygously deleted fragile region. Aberrant transcripts of the FHIT locus were found in approximately 50% of esophageal, stomach, and colon carcinomas."
 
Gene Symbol TOPORS
Description Fomr COSMIC:
 
Gene Symbol CTNNB1
Description Fomr COSMIC:
 
Gene Symbol CDH1
Description Fomr COSMIC:
 
Gene Symbol BRAF
Description Fomr COSMIC:
 
Gene Symbol K-RAS
Description Fomr COSMIC:
 
Gene Symbol PTCH
Description Fomr COSMIC:
 
Gene Symbol MADH4
Description Fomr COSMIC:
 
Gene Symbol RB1
Description Fomr COSMIC:
 
Gene Symbol HRAS
Description Fomr COSMIC:
 
Gene Symbol PTENP1
Description Fomr COSMIC:
 
Gene Symbol CDKN2A
Description Fomr COSMIC:
 
Gene Symbol APC
Description Fomr COSMIC:
 
Gene Symbol PIK3CA
Description Fomr COSMIC:
 
Bibliography
Title "The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. "
Authors "Ohta, M.; Inoue, H.; Cotticelli, M. G.; Kastury, K.; Baffa, R.; Palazzo, J.; Siprashvili, Z.; Mori, M.; McCue, P.; Druck, T.; Croce, C. M.; Huebner, K."
Citations "Cell 84: 587-597, 1996. "
PubMedID 8598045
 
Title Widespread requirement for hedgehog ligand stimulation in growth of digestive tract tumours.
Authors "Berman, D. M.; Karhadkar, S. S.; Maitra, A.; Montes de Oca, R.; Gerstenblith, M. R.; Briggs, K.; Parker, A. R.; Shimada, Y.; Eshleman, J. R.; Watkins, D. N.; Beachy, P. A. "
Citations "Nature 425: 846-851, 2003. "
PubMedID 14520411
 
Title Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines.
Authors Yang, Z.-Q.; Imoto, I.; Fukuda, Y.; Pimkhaokham, A.; Shimada, Y.; Imamura, M.; Sugano, S.; Nakamura, Y.; Inazawa, J.
Citations Cancer Res.60: 4735-4739,2000.
PubMedID 10987278
 
Source and Citation
Source NCI
Citation "NCI, URL:http://www.cancer.gov/cancertopics/types/esophageal/"
URL http://www.cancer.gov/cancertopics/types/esophageal/