Cancer Report

Cancer : Lung: small cell cancer
Summary
Cancer Name Lung: small cell cancer
Description Although it is possible to distinguish a number of different histological sub-classes of lung cancer by light microscopy, the most important current clinical distinction is between small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). Based primarily on its clinical behaviour, SCLC, a neuroendocrine lesion, is considered as a separate entity to the non-small cell carcinomas. The disease has a particularly aggressive clinical course with widespread early metastasis and somewhat in contrast to NSCLC, tumours will frequently show a short term response to cytotoxic chemotherapy and radiotherapy. As SCLC is almost always overtly metastatic at presentation, surgical resection is rare.
 
Clinics and Pathology
Treatment SCLC is highly sensitive to chemotherapy. Response rates vary between 50-90% depending on the stage of disease and the patient's tolerance of the chemotherapy. Survival and quality of life are generally highly improved. In extensive disease, several (up to six) cycles of a platinum containing combination therapy is usually administered. In case of relapse further chemotherapy is given with less success, but even in this situation, quality of life might be improved. In limited disease, combination chemotherapy concomitantly with radiotherapy is the cornerstone of management. In the case of complete remission, initial therapy is completed by a prophylactic cranial irradiation.
 
Related Genes
Gene Symbol SHC3
Description From COSMIC:
 
Gene Symbol PTPRD
Description From COSMIC:
 
Gene Symbol CASP5
Description From COSMIC:
 
Gene Symbol PTPRB
Description From COSMIC:
 
Gene Symbol PLCXD3
Description From COSMIC:
 
Gene Symbol TGFBR1
Description From COSMIC:
 
Gene Symbol SIAH2
Description From COSMIC:
 
Gene Symbol PTPRM
Description From COSMIC:
 
Gene Symbol CASP4
Description From COSMIC:
 
Gene Symbol CASP14
Description From COSMIC:
 
Gene Symbol NPR1
Description From COSMIC:
 
Gene Symbol TOX
Description From COSMIC:
 
Gene Symbol KIAA1303
Description From COSMIC:
 
Gene Symbol CTNNA2
Description From COSMIC:
 
Gene Symbol ZNF423
Description From COSMIC:
 
Gene Symbol ARHGAP23
Description From COSMIC:
 
Gene Symbol CARD12
Description From COSMIC:
 
Gene Symbol PTPRT
Description From COSMIC:
 
Gene Symbol PTPRN
Description From COSMIC:
 
Gene Symbol CTNNB1
Description From COSMIC:
 
Gene Symbol GRK4
Description From COSMIC:
 
Gene Symbol SGK494
Description From COSMIC:
 
Gene Symbol KIT
Description From COSMIC:
 
Gene Symbol EPHB3
Description From COSMIC:
 
Gene Symbol PLCD3
Description From COSMIC:
 
Gene Symbol NIPBL
Description From COSMIC:
 
Gene Symbol CDC27
Description From COSMIC:
 
Gene Symbol SERPINB7
Description From COSMIC:
 
Gene Symbol ARHGAP9
Description From COSMIC:
 
Gene Symbol COPS2
Description From COSMIC:
 
Gene Symbol HERC2
Description From COSMIC:
 
Gene Symbol PPFIA2
Description From COSMIC:
 
Gene Symbol TNFAIP3
Description From COSMIC:
 
Gene Symbol EPHA6
Description From COSMIC:
 
Gene Symbol COX4I1
Description From COSMIC:
 
Gene Symbol SGK
Description From COSMIC:
 
Gene Symbol HERC5
Description From COSMIC:
 
Gene Symbol TERT
Description From COSMIC:
 
Gene Symbol SCYL2
Description From COSMIC:
 
Gene Symbol TNFRSF9
Description From COSMIC:
 
Gene Symbol TERF2
Description From COSMIC:
 
Gene Symbol TNFSF8
Description From COSMIC:
 
Gene Symbol WDFY1
Description From COSMIC:
 
Gene Symbol CBLL1
Description From COSMIC:
 
Gene Symbol NLGN1
Description From COSMIC:
 
Gene Symbol HDGF
Description From COSMIC:
 
Gene Symbol ARID4A
Description From COSMIC:
 
Gene Symbol MMP3
Description From COSMIC:
 
Gene Symbol ERCC1
 
Gene Symbol SATB1
Description From COSMIC:
 
Gene Symbol PIK3CA
Description From COSMIC:
 
Gene Symbol TAF1L
Description From COSMIC:
 
Gene Symbol K-RAS
Description From COSMIC:
 
Gene Symbol SCLC1
Description From LuGenD (lung cancer gene database):
 
Gene Symbol MMP10
Description From COSMIC:
 
Gene Symbol HNF4A
Description From COSMIC:
 
Gene Symbol COH1
Description From COSMIC:
 
Gene Symbol EGFR
Description From COSMIC:
 
Gene Symbol HK2
Description From COSMIC:
 
Gene Symbol RSPO2
Description From COSMIC:
 
Gene Symbol CLSPN
Description From COSMIC:
 
Gene Symbol TAOK3
Description From COSMIC:
 
Gene Symbol CLCN4
Description From COSMIC:
 
Gene Symbol APBB1IP
Description From COSMIC:
 
Gene Symbol CAD
Description From COSMIC:
 
Gene Symbol TOPORS
Description From COSMIC:
 
Gene Symbol STK31
Description From COSMIC:
 
Gene Symbol KITLG
Description SCF is expressed in small-cell lung cancer (SCLC); abundant expression of SCF and c-Kit mRNA was seen in 32% of SCLC cell lines and 66% of SCLC tumors; an autocrine mechanism in the pathogenesis of SCLC is strongly suggested.
 
Gene Symbol STK3
Description From COSMIC:
 
Gene Symbol APC
Description From COSMIC:
 
Gene Symbol ROR2
Description From COSMIC:
 
Gene Symbol CHC1L
Description From COSMIC:
 
Gene Symbol MET
Description From COSMIC:
 
Gene Symbol RORB
Description From COSMIC:
 
Gene Symbol CHD1L
Description From COSMIC:
 
Gene Symbol DNAJC6
Description From COSMIC:
 
Gene Symbol CDKN2A
Description From COSMIC:
 
Gene Symbol TRPM6
Description From COSMIC:
 
Gene Symbol BCORL1
Description From COSMIC:
 
Gene Symbol RIMS2
Description From COSMIC:
 
Gene Symbol TRIP
Description From COSMIC:
 
Gene Symbol HSPA4
Description From COSMIC:
 
Gene Symbol MADH4
Description From COSMIC:
 
Gene Symbol PDCD1LG1
Description From COSMIC:
 
Gene Symbol BIRC8
Description From COSMIC:
 
Gene Symbol PCNA
Description From COSMIC:
 
Gene Symbol RIF1
Description From COSMIC:
 
Gene Symbol TTBK2
Description From COSMIC:
 
Gene Symbol DMPK
Description From COSMIC:
 
Gene Symbol MYBL2
Description From COSMIC:
 
Gene Symbol MYCL1
Description From cancer gene census of CGP:
 
Gene Symbol PAXIP1L
Description From COSMIC:
 
Gene Symbol STK11
Description From COSMIC:
 
Gene Symbol FER
Description From COSMIC:
 
Gene Symbol RGSL2
Description From COSMIC:
 
Gene Symbol RAF1
Description "SCLC tends to present with metastatic and regional spread. Carcinoids rarely metastasize, arise from major bronchi, and express neuron-specific enolase, chromogranin, and synaptophysin. Neuroendocrine carcinoids or atypical carcinoids have a more aggressive course."
 
Gene Symbol LOC390668
Description From COSMIC:
 
Gene Symbol TRIM36
Description From COSMIC:
 
Gene Symbol LOC440917
Description From COSMIC:
 
Gene Symbol SNIP1
Description From COSMIC:
 
Gene Symbol PTCH2
Description From COSMIC:
 
Gene Symbol RET
Description From COSMIC:
 
Gene Symbol TRIM31
Description From COSMIC:
 
Gene Symbol PDZRN4
Description From COSMIC:
 
Gene Symbol PTENP1
Description From COSMIC:
 
Gene Symbol FLJ23119
Description From COSMIC:
 
Gene Symbol FAM5C
Description From COSMIC:
 
Gene Symbol IMPDH1
Description From COSMIC:
 
Gene Symbol MSH4
Description From COSMIC:
 
Gene Symbol FLJ23356
Description From COSMIC:
 
Gene Symbol FLT1
Description From COSMIC:
 
Gene Symbol TRIM42
Description From COSMIC:
 
Gene Symbol SMG1
Description From COSMIC:
 
Gene Symbol AKAP6
Description From COSMIC:
 
Gene Symbol NCOA2
Description From COSMIC:
 
Gene Symbol FUBP1
Description From COSMIC:
 
Gene Symbol PPM1E
Description From COSMIC:
 
Gene Symbol GAB1
Description From COSMIC:
 
Gene Symbol SMARCF1
Description From COSMIC:
 
Gene Symbol VHL
Description From COSMIC:
 
Gene Symbol ITGB6
Description From COSMIC:
 
Gene Symbol RB1
Description From COSMIC, cancer gene census of CGP
 
Gene Symbol PREX1
Description From COSMIC:
 
Gene Symbol FOXN4
Description From COSMIC:
 
Gene Symbol ESPL1
Description From COSMIC:
 
Gene Symbol ATRX
Description From COSMIC:
 
Gene Symbol PPP5C
Description From COSMIC:
 
Gene Symbol CDC5L
Description From COSMIC:
 
Gene Symbol NUMA1
Description From COSMIC:
 
Gene Symbol USP8
Description From COSMIC:
 
Gene Symbol FOXR2
Description From COSMIC:
 
Gene Symbol NUP153
Description From COSMIC:
 
Gene Symbol JAG1
Description From COSMIC:
 
Gene Symbol ADAMTS19
Description From COSMIC:
 
Gene Symbol ERCC6
Description From COSMIC:
 
Gene Symbol ADAMTS3
Description From COSMIC:
 
Gene Symbol GMPS
Description From COSMIC:
 
Gene Symbol TTN
Description From COSMIC:
 
Gene Symbol BAI3
Description From COSMIC:
 
Gene Symbol ADAMTS1
Description From COSMIC:
 
Gene Symbol SKIP
Description From COSMIC:
 
Gene Symbol PAK6
Description From COSMIC:
 
Gene Symbol TFF3
Description "Inflamatory bowel diseases, TFF3 is expressed in cancer cells derived from the gastrointestinal tract, in http://atlasgeneticsoncology.org/Tumors/HepatoCarcinID5039.html, hepatocellular carcinoma cells and in http://atlasgeneticsoncology.org/Tumors/LungTumOverviewID5030.html, small cell lung carcinoma cells. Like TFF1, TFF3 is expressed in oestrogen-responsive breast cancer cell line and is expressed in http://atlasgeneticsoncology.org/Tumors/breastID5018.html, breast cancer ."
 
Gene Symbol PRKG1
Description From COSMIC:
 
Gene Symbol ADAM22
Description From COSMIC:
 
Gene Symbol N4BP2
Description From COSMIC:
 
Gene Symbol P2RX7
Description From COSMIC:
 
Gene Symbol NALP1
Description From COSMIC:
 
Gene Symbol ADAM30
Description From COSMIC:
 
Gene Symbol CUL4B
Description From COSMIC:
 
Gene Symbol NAV3
Description From COSMIC:
 
Gene Symbol ERCC-3
Description From COSMIC:
 
Bibliography
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Authors Testa JR, Liu Z, Feder M, et al.
Citations Cancer Genet Cytogenet 1997; 95: 20-32
PubMedID 9696041
 
Title Chromosomal imbalances in human lung cancer.
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Citations Oncogene 2002; 21: 6877-6883
PubMedID 9696041
 
Title Classification of small cell lung cancer and pulmonary carcinoid by gene expression profiles.
Authors Anbazhagan R, Tihan T, Bornman DM, et al.
Citations Cancer Res 1999; 59: 5119-5122
PubMedID 10547597
 
Title Expression of p16 and lack of pRB in primary small cell lung cancer.
Authors Yuan J, Knorr J, Altmannsberger M, Goeckenjan G et al.
Citations J Pathol 1999; 189: 358-362
PubMedID 12362270
 
Title High frequency of somatically acquired p53 mutations in small-cell lung cancer cell lines and tumors.
Authors D'Amico D, Carbone D, Mitsudomi T et al.
Citations Oncogene 1992; 7: 339-346
PubMedID 1312696
 
Title Lung Cancer: Principles and Practice
Authors Pass HI, Mitchell JB, Johnson DH
Citations Lippincott Williams & Wilkins, Philadelphia (pubs); 2000 ISBN 0-7817-1791-4
PubMedID 12362274
 
Title Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers.
Authors Zabarovsky ER, Lerman MI, Minna JD.
Citations Oncogene 2002; 21: 6915-6935
PubMedID 9140450
 
Title Pathology of the Lung: second edition
Authors Thurlbeck WM and Churg AM (Eds)
Citations Thieme Medical Publishers, Inc. NY; 1995 ISBN 0-86577-543-6
PubMedID 9140450
 
Title PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers.
Authors Yokomizo A, Tindall DJ, Drabkin H et al.
Citations Oncogene 1998; 17: 475-479
PubMedID 10537285
 
Title MYC family DNA amplification in 107 tumors and tumor cell lines from patients with small cell lung cancer treated with different combination chemotherapy regimens.
Authors Brennan J, O'Connor T, Makuch RW et al.
Citations Cancer Res. 1991; 51: 1708-1712
PubMedID 1847842
 
Source and Citation
Source Atlas of Genetics and Cytogenetics in Oncology and Haematology
Citation Heighway J, Betticher DC . Lung: small cell cancer. Atlas Genet Cytogenet Oncol Haematol. June 2004 .
URL : http://AtlasGeneticsOncology.org/Tumors/LungSmallCellID5142.html
URL http://AtlasGeneticsOncology.org/Tumors/LungSmallCellID5142.html