Cancer Report

Cancer : Liver adenoma
Cancer Name Liver adenoma
Cancer Alias Hepatocellular adenoma, Liver cell adenoma
Clinics and Pathology
Disease Hepatocellular adenomas (HA) are rare benign liver tumors, most frequently occurring in women using oral contraception. HA are single or more rarely multiple nodules; the presence of more than ten nodules in the liver indicates a specific nosological entity: liver adenomatosis
Etiology In 90% of the cases, adenomas are sporadic and only rare cases are developed in a familial context: ( Familial liver adenomatosis). Patients with an inherited mutation in one allele of TCF1/HNF1a may develop maturity onset diabetes of the young type 3 (MODY3) and familial liver adenomatosis, when the second allele is inactivated in hepatocytes by somatic mutation or chromosome deletion.
Epidemiology Hepatocellular adenomas are usually related to oral contraceptive use. The other risk factors are? glycogen storage diseases and the androgen therapy. HA are rare tumours: their estimated incidence in France is approximately one case per 100,000 women. Over the past fifteen years, their incidence has seen a sustained decline in industrialised countries; this trend is probably linked to the reduction in ethinylestradiol doses in oral contraceptives.
Pathology These tumours result from a benign proliferation of hepatocytes which destroy the normal architecture of the liver. They are usually hyper-vascularised and typical adenoma corresponds to a proliferation of benign hepatocytes, intermingled with numerous thin-walled vessels, without portal tracts.
Treatment Surgery is usually proposed for lesion of more than 3 cm
Prognosis The molecular and pathological classification of hepatocellular adenomas permits the identification of strong genotype-phenotype correlations and suggests that adenomas with beta-catenin activation have a higher risk of malignant transformation.
Related Genes
Gene Symbol APC
Description From COSMIC:
Gene Symbol CDKN2A
Description From COSMIC:
Gene Symbol BRAF
Description From COSMIC:
Gene Symbol CTNNB1
Description From COSMIC:
Title P53 gene and Wnt signaling in benign neoplasms: beta-catenin mutations in hepatic adenoma but not in focal nodular hyperplasia.
Authors Chen YW, Jeng YM, Yeh SH, Chen PJ.
Citations Hepatology 2002; 36: 927-935.
PubMedID 12297840
Title Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3).
Authors Yamagata K, Oda N, Kaisaki PJ, Menzel S, Furuta H, Vaxillaire M, Southam L, Cox RD, Lathrop GM, Boriraj VV, Chen X, Cox NJ, Oda Y, Yano H, Le Beau MM, Yamada S, Nishigori H, Takeda J, Fajans SS, Hattersley AT, Iwasaki N, Hansen T, Pedersen O, Polonsky KS, Bell GI, et al.
Citations Nature 1996 Dec 5; 384(6608): 455-458.
PubMedID 8945470
Title Liver adenomatosis. An entity distinct from liver adenoma?
Authors Flejou JF, Barge J, Menu Y, Degott C, Bismuth H, Potet F, et al.
Citations Gastroenterology 1985; 89: 1132-1138.
PubMedID 2412930
Title Hepatocyte nuclear factor-1 alpha gene inactivation: cosegregation between liver adenomatosis and diabetes phenotypes in two maturity-onset diabetes of the young (MODY)3 families.
Authors Reznik Y, Dao T, Coutant R, Chiche L, Jeannot E, Clauin S, Rousselot P, Fabre M, Oberti F, Fatome A, Zucman-Rossi J, Bellanne-Chantelot C.
Citations J Clin Endocrinol Metab 2004; 89: 1476-1480.
PubMedID 15001650
Title Liver-cell adenomas associated with use of oral contraceptives.
Authors Edmondson HA, Henderson B, Benton B.
Citations N Engl J Med 1976; 294: 470-472.
PubMedID 173996
Title Liver adenomatosis: reappraisal, diagnosis, and surgical management: eight new cases and review of the literature.
Authors Chiche L, Dao T, Salame E, Galais MP, Bouvard N, Schmutz G, Rousselot P, Bioulac-Sage P, Segol P, Gignoux M.
Citations Ann Surg 2000; 231: 74-81.
PubMedID 10636105
Title Familial liver adenomatosis associated with hepatocyte nuclear factor 1alpha inactivation.
Authors Bacq Y, Jacquemin E, Balabaud C, Jeannot E, Scotto B, Branchereau S, Laurent C, Bourlier P, Pariente D, de Muret A, Fabre M, Bioulac-Sage P, Zucman-Rossi J.
Citations Gastroenterology 2003; 125: 1470-1475.
PubMedID 14598263
Title Bi-allelic inactivation of TCF1 in hepatic adenomas.
Authors Bluteau O, Jeannot E, Bioulac-Sage P, Marques JM, Blanc JF, Bui H, Beaudoin JC, Franco D, Balabaud C, Laurent-Puig P, Zucman-Rossi J.
Citations Nat Genet 2002; 32: 312-315.
PubMedID 12355088
Title Genotype-phenotype correlation in hepatocellular adenoma: New classification and relationship with HCC.
Authors Zucman-Rossi J, Jeannot E, Van Nhieu JT, Scoazec JY, Guettier C, Rebouissou S, Bacq Y, Leteurtre E, Paradis V, Michalak S, Wendum D, Chiche L, Fabre M, Mellottee L, Laurent C, Partensky C, Castaing D, Zafrani ES, Laurent-Puig P, Balabaud C, Bioulac-Sage P.
Citations Hepatology 2006; 43: 515-524.
PubMedID 16496320
Title Familial liver-cell adenomas and diabetes mellitus.
Authors Foster JH, Donohue TA, Berman MM.
Citations N Engl J Med 1978; 299: 239-241.
PubMedID 207987
Source and Citation
Source Atlas of Genetics and Cytogenetics in Oncology and Haematology
Citation Zucman-Rossi J . Liver adenoma. Atlas Genet Cytogenet Oncol Haematol. March 2006 .