Cancer Report

Cancer : Liver adenoma
Summary
Cancer Name Liver adenoma
Cancer Alias Hepatocellular adenoma, Liver cell adenoma
 
Clinics and Pathology
Disease Hepatocellular adenomas (HA) are rare benign liver tumors, most frequently occurring in women using oral contraception. HA are single or more rarely multiple nodules; the presence of more than ten nodules in the liver indicates a specific nosological entity: liver adenomatosis
Etiology In 90% of the cases, adenomas are sporadic and only rare cases are developed in a familial context: ( Familial liver adenomatosis). Patients with an inherited mutation in one allele of TCF1/HNF1a may develop maturity onset diabetes of the young type 3 (MODY3) and familial liver adenomatosis, when the second allele is inactivated in hepatocytes by somatic mutation or chromosome deletion.
  
Epidemiology Hepatocellular adenomas are usually related to oral contraceptive use. The other risk factors are? glycogen storage diseases and the androgen therapy. HA are rare tumours: their estimated incidence in France is approximately one case per 100,000 women. Over the past fifteen years, their incidence has seen a sustained decline in industrialised countries; this trend is probably linked to the reduction in ethinylestradiol doses in oral contraceptives.
Pathology These tumours result from a benign proliferation of hepatocytes which destroy the normal architecture of the liver. They are usually hyper-vascularised and typical adenoma corresponds to a proliferation of benign hepatocytes, intermingled with numerous thin-walled vessels, without portal tracts.
Treatment Surgery is usually proposed for lesion of more than 3 cm
Prognosis The molecular and pathological classification of hepatocellular adenomas permits the identification of strong genotype-phenotype correlations and suggests that adenomas with beta-catenin activation have a higher risk of malignant transformation.
 
Related Genes
Gene Symbol APC
Description From COSMIC:
 
Gene Symbol CDKN2A
Description From COSMIC:
 
Gene Symbol BRAF
Description From COSMIC:
 
Gene Symbol CTNNB1
Description From COSMIC:
 
Bibliography
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Authors Reznik Y, Dao T, Coutant R, Chiche L, Jeannot E, Clauin S, Rousselot P, Fabre M, Oberti F, Fatome A, Zucman-Rossi J, Bellanne-Chantelot C.
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PubMedID 15001650
 
Title Liver-cell adenomas associated with use of oral contraceptives.
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PubMedID 173996
 
Title Liver adenomatosis: reappraisal, diagnosis, and surgical management: eight new cases and review of the literature.
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Title Familial liver adenomatosis associated with hepatocyte nuclear factor 1alpha inactivation.
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Title Bi-allelic inactivation of TCF1 in hepatic adenomas.
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Title Genotype-phenotype correlation in hepatocellular adenoma: New classification and relationship with HCC.
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PubMedID 16496320
 
Title Familial liver-cell adenomas and diabetes mellitus.
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PubMedID 207987
 
Source and Citation
Source Atlas of Genetics and Cytogenetics in Oncology and Haematology
Citation Zucman-Rossi J . Liver adenoma. Atlas Genet Cytogenet Oncol Haematol. March 2006 .
URL : http://AtlasGeneticsOncology.org/Tumors/LiverAdenomID5420.html
URL http://AtlasGeneticsOncology.org/Tumors/LiverAdenomID5420.html