Cancer Report

Cancer : t(9;12)(q34;p13)
Cancer Name t(9;12)(q34;p13)
Clinics and Pathology
Disease described in only 6 cases; acute lymphoblastic leukemia (ALL), acute non lymphocytic leukemia (ANLL) and chronic myeloid leukemia (CML)
Prognosis numbers small, but one CML case had allogeneic BMT and is in complete remission, the remaining cases had rapid disease progression and died of shortly after diagnosis
Related Genes
Gene Symbol ABL1
Description "common ALL; yet poorly known. ETV6 is fused to exon 2 of ABL in the three cases describedtyrosine kinase, localized primarily to the nucleus"
Gene Symbol ETV6
Description "9 exons; alternate splicingcontains Helix-Loop-Helix (HLH) at N-terminal end and ETS DNA binding domain at C-terminal end; wide expression; nuclear localization; ETS- related transcription factor, Acute myeloblastic leukemia (AML) ,, chronic myelogenous leukemia (CML) , acute lymphocytic leukemia (ALL) "
Title Bcr/Abl activates transcription of the Bcl-0X gene through STAT5.
Authors Gesbert F, Griffin JD.
Citations Blood 2000; 96: 2269-2276.
PubMedID 20435360
Title Haemopoietic transformation by the TEL/ABL oncogene.
Authors Hannemann JR, McManus DM, Kabarowski JHS, Wiedemann LM.
Citations Br J Haematol 1998; 102: 475-485.
PubMedID 98359133
Title BCR/ABL-negative chronic myeloid leukemia with ETV6/ABL fusion.
Authors Andreasson P, Johansson B, Carlsson M, Jarlsfelt I, Fioretos T, Mitelman F, Hšglund M.
Citations Genes Chromosom Cancer 1997; 20: 299-304.
PubMedID 98032542
Title The novel activation of ABL by fusion to an ets-related gene TEL.
Authors Papadopoulos P, Ridge SA, Boucher CA, Stocking C, Wiedemann LM.
Citations Cancer Res 1995; 55: 34-38.
PubMedID 9513529
Title Transforming properties of chimeric TEL-JAK proteins in Ba/F3 cells.
Authors Lacronique V, Boureaux A, Monni R, Dumon S, Mauchauff?M, Mayeux P, Gouilleux F, Berger R, Gisselbrecht S, Ghysdael J, Bernard OA.
Citations Blood 2000; 95; 2076-2083.
PubMedID 20173576
Title Molecular cytogenetic and clinical findings in ETV6/ABL1-positive leukemia.
Authors Van Limbergen H, Beverloo HB, van Drunen E, Janssens A, HŠhlen K, Poppe B, Van Roy N, Marynen P, De Paepe A, Slater R, Speleman F.
Citations Genes Chromosom Cancer 2001; Published Online: 20 Dec 2000
PubMedID 98359133
Title Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia.
Authors Golub TR, Goga A, Barker GF, Afar DEH, McLaughlin J, Bohlander SK, Rowley JD, Witte WN, Gilliland DG.
Citations Molec Cell Biol 1996; 16: 4107-4116.
PubMedID 96315635
Source and Citation
Source Atlas of Genetics and Cytogenetics in Oncology and Haematology
Citation Heerema NA . t(9;12)(q34;p13). Atlas Genet Cytogenet Oncol Haematol. December 2000 .