Cancer Report

Cancer : Kidney: Chromophobe renal cell carcinoma
Cancer Name Kidney: Chromophobe renal cell carcinoma
Description Chromophobe renal cell carcinoma (ChRCC) is a distinct subtype of renal cell carcinoma, possibly originating from the intercalated cells of the collecting tubules, as oncocytoma .
Clinics and Pathology
Epidemiology It comprises approximately 5% of all renal tumors.
  • Large polygonal cells with pale, flocculent cytoplasm and very distinct plasmalemmal outlines. The cells are arranged in solid nests or tubules. Ultrastructurally, the flocculence of the cytoplasm has been found to be due to large numbers of minute vesicles. Hale's colloid iron histochemical characteristically colors the cytoplasm diffusely blue. Although two histological variants are recognized, a typical and an eosinophilic one (increased numbers of mitochondria), both cell types may occur in the same tumor.
  • Rare example of composite oncocytoma/chromophobe RCC tumors have been described leading, to the hypothesis that the two types of tumors may be related. Recently, immunohistochemical staining for the RCC antigen and CD10 has been proposed as a possiblly useful adjunct in the differential diagnoses of chromophobe RCC vs clear cell type RCC and chromophobe RCC vs oncocytoma. There is evidence that chromophobe RCCs are less likely to behave aggressively than otherwise similar clear cell type RCCs.
    Related Genes
    Gene Symbol VHL
    Description From COSMIC:
    Gene Symbol TTN
    Description From COSMIC:
    Gene Symbol IGF1R
    Description From COSMIC:
    Gene Symbol QSK
    Description From COSMIC:
    Cytogenetics Morphological Chromophobe RCCs generally have a tendency to grow very slowly in vitro in comparison to all other type of renal tumors. This may be a reason why cytogenetic reports are scarce and usually few metaphases of poor quality were available for investigation. A low chromosome number ranging between 32-39, without discernable structural changes was the most frequent cytogenetic finding. Chromosomes 1, 2, 6, 10, 13, 17 and 21 were most frequently lost. Additional structural aberrations have been described. Endoreduplication of the cells with hypodiploid karyotype has been observed. It is of interest, the presence of an hypodiploid clone can be disclosed by a DNA index of 0.86. The low chromosome number has been confirmed by other techniques such as flow cytometry, comparative genomic hybridization (CGH), restriction fragment length polymorphism (RFLP) analysis, and polymorphic microsatellite markers.
    Title Cytogenetic analysis of 6 renal oncocytomas and a chromophobe renal cell carcinoma: Evidence that -Y, -1 may be a characteristic anomaly in renal oncocytomas
    Authors Crotty TB, Lawrence KM, Moertel CA, Bartelt DH, Batts KP, Dewald GW, Farrow GM,Jenkins RB
    Citations Cancer Genet Cytogenet 1992, 61:61-66.
    PubMedID 1382570
    Title Colloidal iron staining in renal epithelial neoplasms, including chromophobe renal cell carcinoma. Emphasis on technique and patterns of staining.
    Authors Tickoo SK, Ajmin MBG, Zarbo RJ
    Citations Am J Surg Pathol 1998,22:419-424.
    PubMedID 10680888
    Title Chromosome changes in a metastasis of a chromophobe renal cell tumor.
    Authors Dijkhuizen T, van den Berg E, St–rkel S, de Jong B.
    Citations Cancer Genet Cytogenet 1998, 100:1-5.
    PubMedID 10478670
    Title Chromophobe renal cell carcinoma. Pathologic, ultrastructural , immunohistochemical, cytofluorometric and cytogenetic findings
    Authors Morell-Quadreny L, Gregory-Romero M, Lombart-Bosch a
    Citations Path Res Pract 1996, 192:1275-1281
    PubMedID 9042156
    Title Chromophobe cell renal carcinoma: Clinicopathological features of 50 cases..
    Authors Crotty TB, Farrow GM, Lieber MM
    Citations J Urol 1995, 154:964-967.
    PubMedID 7717462
    Title Chromophobe cell carcinoma: analysis of five cases
    Authors Bonsib SM, Lagger DJ.
    Citations Am J Surg Pathol 1990,14:260-267.
    PubMedID 1638482
    Title Chromophobe cell carcinoma of the kidney: A clinicopathological study of 21 cases.
    Authors Akhtar M, Kardar H, Linjawi T, McClintock J, Ali MA
    Citations Am J Surg Pathol 1995, 19:1245-1256.
    PubMedID 7637102
    Title Binucleated cell in a human renal cell carcinoma with 34 chromosomes.
    Authors Kovacs G, Soudah B, Hoene E
    Citations Cancer Genet Cytogenet 1988, 31:211-215.
    PubMedID 3349439
    Title Specific genetic changes of diagnostic importance in chromophobe renal cell carcinomas.
    Authors Bugert P, Gaul C, Weber K, Herbers J, Akhtar M, Ljungberg B,Kovacs G.
    Citations Lab Invest 1997,76:203-208.
    PubMedID 9537468
    Title Renal Oncocytosis. A morphology study of fourteen cases
    Authors Tickoo SK, Reuter VE, Amin MB, Srigley JR, Epstein JI, Min K-W, Rubin MA, Ro JY
    Citations Am J Surg Pathol 1999,29:1094-1101
    PubMedID 10613963
    Title Multitechnical pathological diagnosis in chromophobe renal cell carcinoma
    Authors Balzarini P, Grigolato P, Tardanico R, Cadei M, Cosciani Cunico S, Cozzoli A, Zanotelli T, Van Den Berghe H, Dal Cin P
    Citations Oncol Rep 1999, 6:295-299.
    PubMedID 10613963
    Title Low chromosome number in chromophobe renal cell carcinoma.
    Authors Kovacs A , Kovacs G
    Citations Genes Chromosom Cancer 1992 ,4:267-268.
    PubMedID 7519827
    Title Histopathology and classification of renal cell tumors (adenomas, oncocytoma and carcinomas). The basic cytological and histopathological elements and their use for diagnostics.
    Authors Thoenes W, St–rkel S, Rumpelt HJ.
    Citations Path Res Pract 1996, 181:125-143.
    PubMedID 9689937
    Title Establishment and characterization of two divergent cell lines derived from human chromophobe renal cell carcinoma.
    Authors Gerhaz CD, Moll R, Storkel S, Ramp U, Hildebrandt B, Mollsberg G, Koldovsky P,Gabbert HE
    Citations Am J Pathol , 1995, 146:953-962.
    PubMedID 8816891
    Title Diagnosis of chromophobe renal cell carcinoma by chromosomal analysis
    Authors Marras S, Faa G, Scarpa R, Valdes E, Vanni R
    Citations Tumori 1997, 83:753-755.
    PubMedID 10022992
    Title Cytogenetic findings in renal cell carcinoma.
    Authors Iqbal MA, Akhtar M and Ali MA.
    Citations Hum Pathol 1996, 27:949-954.
    PubMedID 8674042
    Title Use of antibodies to RCC and CD10 in the differential diagnosis of renal neoplasm
    Authors Avery AK, Beckstead J, Renshaw AA, Corless CL
    Citations Am J Surg Pathol 2000, 24:203-210
    PubMedID 2305931
    Title Specific loss of chromosomes 1, 2, 6, 10, 13, 17, and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridization.
    Authors Speicher MR, Schoell B, du Manoir S, Schr–ck E, Ried T, Cremer T, St–rkel S, Kovacs A,Kovacs G.
    Citations Am J Pathol 1994, 145:356-364.
    PubMedID 7573686
    Title The human chromophobe cell renal carcinoma: its probable relation to intercalated cells of the collecting duct.
    Authors St–rkel S, Stoart PV, Dronckhahn D and Thoenes W.
    Citations Virchows Archiv B Cell Pathol 1989,56:237-245.
    PubMedID 2305931
    Title . FISH analysis in chromophobe renal cell carcinoma
    Authors Iqbal MA, Akhtar M, Ulmer C, AL-Dayel F, Paterson MC
    Citations Diagn Cytopathol 2000, 22:3-6
    PubMedID 98270918
    Title Allelic losses at chromosomes 1p, 2p, 6p, 10p, 13q, 17p, and 21q significantly with the chromophobe subtype of renal cell carcinoma.
    Authors Schwerdtle RF, St–rkel S, Neuhaus C, Brauch H, Weidt E, Brenner W, Hohenfellner R, Huber C, Decker H-J.
    Citations Cancer Res 1996, 56:2927-2930.
    PubMedID 9349316
    Source and Citation
    Source Atlas of Genetics and Cytogenetics in Oncology and Haematology
    Citation Dal Cin P . Kidney: Chromophobe renal cell carcinoma. Atlas Genet Cytogenet Oncol Haematol. October 2001 .
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