Cancer Report

Cancer : Kidney: Chromophobe renal cell carcinoma
Summary
Cancer Name Kidney: Chromophobe renal cell carcinoma
Description Chromophobe renal cell carcinoma (ChRCC) is a distinct subtype of renal cell carcinoma, possibly originating from the intercalated cells of the collecting tubules, as oncocytoma .
 
Clinics and Pathology
Epidemiology It comprises approximately 5% of all renal tumors.
Pathology
  • Large polygonal cells with pale, flocculent cytoplasm and very distinct plasmalemmal outlines. The cells are arranged in solid nests or tubules. Ultrastructurally, the flocculence of the cytoplasm has been found to be due to large numbers of minute vesicles. Hale's colloid iron histochemical characteristically colors the cytoplasm diffusely blue. Although two histological variants are recognized, a typical and an eosinophilic one (increased numbers of mitochondria), both cell types may occur in the same tumor.
  • Rare example of composite oncocytoma/chromophobe RCC tumors have been described leading, to the hypothesis that the two types of tumors may be related. Recently, immunohistochemical staining for the RCC antigen and CD10 has been proposed as a possiblly useful adjunct in the differential diagnoses of chromophobe RCC vs clear cell type RCC and chromophobe RCC vs oncocytoma. There is evidence that chromophobe RCCs are less likely to behave aggressively than otherwise similar clear cell type RCCs.
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    Related Genes
    Gene Symbol VHL
    Description From COSMIC:
     
    Gene Symbol TTN
    Description From COSMIC:
     
    Gene Symbol IGF1R
    Description From COSMIC:
     
    Gene Symbol QSK
    Description From COSMIC:
     
    Cytogenetics
    Cytogenetics Morphological Chromophobe RCCs generally have a tendency to grow very slowly in vitro in comparison to all other type of renal tumors. This may be a reason why cytogenetic reports are scarce and usually few metaphases of poor quality were available for investigation. A low chromosome number ranging between 32-39, without discernable structural changes was the most frequent cytogenetic finding. Chromosomes 1, 2, 6, 10, 13, 17 and 21 were most frequently lost. Additional structural aberrations have been described. Endoreduplication of the cells with hypodiploid karyotype has been observed. It is of interest, the presence of an hypodiploid clone can be disclosed by a DNA index of 0.86. The low chromosome number has been confirmed by other techniques such as flow cytometry, comparative genomic hybridization (CGH), restriction fragment length polymorphism (RFLP) analysis, and polymorphic microsatellite markers.
     
    Bibliography
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    Title Chromophobe renal cell carcinoma. Pathologic, ultrastructural , immunohistochemical, cytofluorometric and cytogenetic findings
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    PubMedID 7717462
     
    Title Chromophobe cell carcinoma: analysis of five cases
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    Title Chromophobe cell carcinoma of the kidney: A clinicopathological study of 21 cases.
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    Title Specific genetic changes of diagnostic importance in chromophobe renal cell carcinomas.
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    PubMedID 10613963
     
    Title Multitechnical pathological diagnosis in chromophobe renal cell carcinoma
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    PubMedID 7519827
     
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    PubMedID 9689937
     
    Title Establishment and characterization of two divergent cell lines derived from human chromophobe renal cell carcinoma.
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    PubMedID 8816891
     
    Title Diagnosis of chromophobe renal cell carcinoma by chromosomal analysis
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    PubMedID 10022992
     
    Title Cytogenetic findings in renal cell carcinoma.
    Authors Iqbal MA, Akhtar M and Ali MA.
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    PubMedID 8674042
     
    Title Use of antibodies to RCC and CD10 in the differential diagnosis of renal neoplasm
    Authors Avery AK, Beckstead J, Renshaw AA, Corless CL
    Citations Am J Surg Pathol 2000, 24:203-210
    PubMedID 2305931
     
    Title Specific loss of chromosomes 1, 2, 6, 10, 13, 17, and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridization.
    Authors Speicher MR, Schoell B, du Manoir S, Schr–ck E, Ried T, Cremer T, St–rkel S, Kovacs A,Kovacs G.
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    PubMedID 7573686
     
    Title The human chromophobe cell renal carcinoma: its probable relation to intercalated cells of the collecting duct.
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    PubMedID 2305931
     
    Title . FISH analysis in chromophobe renal cell carcinoma
    Authors Iqbal MA, Akhtar M, Ulmer C, AL-Dayel F, Paterson MC
    Citations Diagn Cytopathol 2000, 22:3-6
    PubMedID 98270918
     
    Title Allelic losses at chromosomes 1p, 2p, 6p, 10p, 13q, 17p, and 21q significantly with the chromophobe subtype of renal cell carcinoma.
    Authors Schwerdtle RF, St–rkel S, Neuhaus C, Brauch H, Weidt E, Brenner W, Hohenfellner R, Huber C, Decker H-J.
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    PubMedID 9349316
     
    Source and Citation
    Source Atlas of Genetics and Cytogenetics in Oncology and Haematology
    Citation Dal Cin P . Kidney: Chromophobe renal cell carcinoma. Atlas Genet Cytogenet Oncol Haematol. October 2001 .
    URL : http://AtlasGeneticsOncology.org/Tumors/ChromophobeRenalID5124.html
    URL http://AtlasGeneticsOncology.org/Tumors/ChromophobeRenalID5124.html