Cancer Report

Cancer : Hodgkin's disease
Summary
Cancer Name Hodgkin's disease
 
Clinics and Pathology
Disease Hodgkin's disease (HD) is generally considered to involve a clonal expansion of neoplastic B lymphocytes
Epidemiology a distinguishing feature with non-Hodgkin's lymphomas (NHLs) is its relative frequency in patients under 20 years
Pathology most HDs can be classified as nodular sclerotic (NS) or mixed cellularity (MS) subtypes; two uncommon subtypes, lymphocyte predominance and lymphocyte depletion, present less typical pictures and examples of the former have sometimes been reclassified as low-grade B-cell NHLs
Prognosis unlike NHLs, the prognosis of HD has improved in recent decades with a five-year survival rate of over 80%
 
Related Genes
Gene Symbol SOCS1
Description From cancer gene census of CGP:
 
Gene Symbol TOPORS
Description From COSMIC:
 
Gene Symbol REL
Description From cancer gene census of CGP:
 
Gene Symbol HRAS
Description From COSMIC:
 
Gene Symbol CDKN2A
Description From COSMIC:
 
Gene Symbol N-RAS
Description From COSMIC:
 
Gene Symbol JUN
Description From OMIM: "Mathas et al. (2002) found AP1 constitutively activated, with robust JUN and JUNB overexpression, in all cell lines derived from patients with classical Hodgkin lymphoma (236000) and anaplastic large cell lymphoma (ALCL), but not in other lymphoma types. AP1 supported proliferation of Hodgkin cells, but suppressed apoptosis of ALCL cells. Mathas et al. (2002) noted that, whereas JUN is upregulated by an autoregulatory process, JUNB is under the control of nuclear factor kappa-B (NFKB; 164011). They found that AP1 and NFKB cooperate and stimulate expression of the cell cycle regulator cyclin D2 (123833), the protooncogene MET (164860), and the lymphocyte homing receptor CCR7 (600242), which are all strongly expressed in primary Hodgkin/Reed-Sternberg (HRS) cells."
 
Bibliography
Title Cytogenetics of Hodgkin's disease.
Authors Atkin NB.
Citations Cytogenet Cell Genet 1998; 80: 23-27.
PubMedID 98378962
 
Title Chromosomal abnormalities in Hodgkin's disease are not restricted to Hodgkin/Reed-Sternberg cells.
Authors Jansen MPHM, Hopman AHN, Haesevoets AM, Gennotte IAF, Bot FJ, Arends JW, Ramaekers FCS, Schouten HC.
Citations J Pathol 1998; 185: 145-152.
PubMedID 99211823
 
Title Precursors of Hodgin's disease and B-cell lymphomas.
Authors Manis JP.
Citations New Engl J Med 1999; 340: 1280-1281.
PubMedID 97382707
 
Title Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa-B.
Authors Mathas, S.; Hinz, M.; Anagnostopoulos, I.; Krappmann, D.; Lietz, A.; Jundt, F.; Bommert, K.; Mechta-Grigoriou, F.; Stein, H.; Dorken, B.; Scheidereit, C.
Citations EMBO J. 21: 4104-4113, 2002.
PubMedID 12145210
 
Title Numerical chromosome aberrations are present within the CD30+ Hodgkin and Reed-Sternberg cells in 100% of analyzed cases of Hodgkin's disease.
Authors Weber-Matthiesen K, Deerberg J, Poetsch M, Grote W, Schlegelberger B.
Citations Blood 1995; 86: 1464-1468
PubMedID 97382707
 
Title Hodgkin's disease.
Authors Kaplan HS:
Citations Second Edition. Harvard University Press, Massachusetts 1980.
PubMedID 95359446
 
Title Hodgkin's disease - Time for a change.
Authors Schwartz RS.
Citations New Engl J Med 1997; 337: 495-496.
PubMedID 98341469
 
Source and Citation
Source Atlas of Genetics and Cytogenetics in Oncology and Haematology
Citation Atkin NB . Hodgkin's disease. Atlas Genet Cytogenet Oncol Haematol. May 1999 .
URL : http://AtlasGeneticsOncology.org/Anomalies/HodgkinID2068.html
URL http://AtlasGeneticsOncology.org/Anomalies/HodgkinID2068.html