Cancer Report

Cancer : 9p Rearrangements in ALL
Summary
Cancer Name 9p Rearrangements in ALL
 
Clinics and Pathology
Disease acute lymphocycic leukemia (ALL)
Epidemiology approximately 10% of childhood ALL, similar in adult ALL
Prognosis recent data indicate that an abnormal 9p is an adverse risk factor for B-lineage, but not T-lineage pediatric patients; this is more pronounced in standard-risk patients (age 1 - 9 years with WBC count <50 X 109/l); a dic(9;12)(p11-13;p11-12) has been reported to have a very low relapse rate
 
Related Genes
Gene Symbol CDKN2A
Description " the different types of 9p aberrations may have different molecular consequences; when a deletion of 9p occurs, the genes involved colud be MTS1/CDK4I/p16INK4A(CDKN2) and MTS2/p15INK4B(CDKN2B); these are believed to be tumor suppressor genes, and loss of heterozygosity occurs more frequently than cytogenetic deletions of 9p; however, mutation of the remaining allele is infrequent, and methylation changes may cause inactivation of the remaining allele. "
 
Bibliography
Title Lymphoblastic leukemia with lymphomatous features associated with abnormalities of the short arm of chromosome 9.
Authors Chilcote RR, Brown E, Rowley JD
Citations N Engl J Med. 1985 Aug 1;313(5):286-91
PubMedID 85240470
 
Title Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells
Authors Drexler HG
Citations Leukemia. 1998 Jun;12(6):845-59. Review
PubMedID 98301281
 
Title Dicentric (9;12) in acute lymphocytic leukemia and other hematological malignancies: report from a dic(9;12) study group.
Authors Behrendt H, Charrin C, Gibbons B, Harrison CJ, Hawkins JM, Heerema NA, Horschler-Botel B, Huret JL, Lai JL, Lampert F, et al
Citations Leukemia. 1995 Jan;9(1):102-6.
PubMedID 95147469
 
Title Lack of association between abnormalities of the chromosome 9 short arm and either "lymphomatous" features or T cell phenotype in childhood acute lymphocytic leukemia.
Authors Carroll AJ, Castleberry RP, Crist W
Citations Blood. 1987 Mar;69(3):735-8.
PubMedID 87129351
 
Title Association of chromosome arm 9p abnormalities with adverse risk in childhood acute lymphoblastic leukemia: A report from the Children's Cancer Group.
Authors Heerema NA, Sather HN, Sensel MG, Liu-Mares W, Lange BJ, Bostrom BC, Nachman JB, Steinherz PG, Hutchinson R, Gaynon PS, Arthur DC, Uckun FM
Citations Blood. 1999 Sep 1;94(5):1537-44
PubMedID 99409024
 
Source and Citation
Source Atlas of Genetics and Cytogenetics in Oncology and Haematology
Citation Heerema NA . 9p Rearrangements in ALL. Atlas Genet Cytogenet Oncol Haematol. August 1999 .
URL : http://AtlasGeneticsOncology.org/Anomalies/9prearrALLID1156.html
URL http://AtlasGeneticsOncology.org/Anomalies/9prearrALLID1156.html